Caspase inhibitor z-VAD-FMK inhibits keratocyte apoptosis, but promotes keratocyte necrosis, after corneal epithelial scrape

Experimental Eye Research

Volumn 71, Issue 3, 2000, Pages 225-232

  Kim, Woo Jung ^a   Mohan, Rahul R ^b   Mohan, Rajiv R ^b   Wilson, Steven E ^b  

^a Sungkyunkwan University   (South Korea)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Caspases; Cornea; Necrosis; Wound healing

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE INHIBITOR; PROPIDIUM IODIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL ULTRASTRUCTURE; CHROMATIN CONDENSATION; CONTROLLED STUDY; CORNEA CELL; CORNEA EPITHELIUM; DRUG EFFECT; ENZYME INHIBITION; MEMBRANE PERMEABILITY; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RABBIT; STROMA CELL; TRANSMISSION ELECTRON MICROSCOPY; WOUND HEALING;

EID: 0033797973     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1006/exer.2000.0872     Document Type: Article

References (29)

1. Fas-induced activation of the cell death-related protease CPP32 is inhibited by Bcl-2 and by ICE family protease inhibitors
2. Critical aspects in the analysis of apoptosis and necrosis
3. A refractive and histopathologic study of excimer laser keratectomy in primates
4. Involvement of an ICE-like protease in Fas-mediated apoptosis
5. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
6. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
7. Apoptosis induced by HIV infection in H9 T cells is blocked by ICE-family protease inhibition but not by a Fas (CD95) antagonist
8. Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques
9. Corneal wound healing in monkeys after repeated excimer laser photorefractive keratectomy
10. Keratocyte apoptosis following corneal surgery
11. The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death
12. Induction of alpha-smooth muscle actin expression and myofibroblast transformation in cultured corneal keratocytes
13. Differences in keratocyte apoptosis following transepithelial and laserscrape photorefractive keratectomy
14. Inhibition of caspase activity induces a switch from apoptosis to necrosis
15. Myofibroblasts differentiate from fibroblasts when plated at low density
16. Electron microscopy of the chromosomes in Dinoflagellate Porocentrum micans: Confirmation of Bouligandiss liquid crystal hypothesis
17. Inhibition of ICE family cysteine proteases rescues murine lymphocytes from lipoxygenase inhibitor-induced apoptosis
18. Bone morphogenic proteins 2 and 4 and their receptors in the adult human cornea
19. Apoptosis in the cornea: Further characterization of Fas/Fas ligand system
20. Cytochemical identification of programmed cell death in the fusing fetal mouse palate by specific labeling of DNA fragmentation
21. Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases
22. ICE inhibitor zVADcmk is a potent therapeutic agent against in vivo liver apoptosis
23. Nf-kB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
24. Programmed cell death, wound healing, and laser refractive surgical procedures: Molecular biology for the corneal surgeon
25. Stimulus-specific and cell type-specific cascades: Emerging principles relating to control of apoptosis
26. Epithelial injury induces keratocyte apoptosis: Hypothesized role for the inter-leukin-1 system in the modulation of corneal tissue organization
27. Keratocyte apoptosis: Implications on corneal wound healing, tissue organization, and disease
28. The Fas/Fas ligand system and other modulators of apoptosis in the cornea
29. Corneal wound healing after 193 nm excimer laser keratectomy