Signs of beta-cell autoimmunity and HLA-defined diabetes susceptibility in the Finnish population: The sib cohort from the Type 1 diabetes prediction and prevention study

Diabetologia

Volumn 46, Issue 1, 2003, Pages 65-70

  Kukko, M ^b   Kimpimaki T ^b   Kupila, A ^c   Korhonen, S ^d   Kulmala, P ^d   Savola, K ^d   Simell, T ^c   Keskinen, P ^c   Ilonen, J ^c   Simell, O ^c   Knip, M ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d UNIVERSITY OF OULU   (Finland)

Author keywords

Autoantibody; Finland; General population; HLA DQB1; Risk group; Type 1 diabetes

Indexed keywords

GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 65 ANTIBODY; GLUTAMATE DECARBOXYLASE ANTIBODY; HLA DQB1 ANTIGEN; IA ANTIBODY; INSULIN ANTIBODY; PANCREAS ISLET CELL ANTIBODY; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ALLELE; ARTICLE; AUTOIMMUNITY; CHILD; COHORT ANALYSIS; DISEASE ASSOCIATION; FEMALE; FINLAND; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PANCREAS ISLET BETA CELL; PREDICTION; PREVALENCE; PRIORITY JOURNAL; SIBLING; STATISTICAL ANALYSIS;

EID: 0037287010     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-002-0976-5     Document Type: Article

References (32)

1. Menon RK, Sperling MA (1988) Childhood diabetes. Med Clin North Am 72:1565-1576
2. Bingley PJ, Gale EAM (1989) Rising incidence of IDDM in Europe. Diabetes Care 12:289-295
3. Karvonen M, Tuomilehto J, Libman I, LaPorte R (1993) A review of the recent epidemiological data on the worldwide incidence of Type I (insulin-dependent) diabetes mellitus. Diabetologia 36: 883-892
4. Diabetes Epidemiology Research International Group (1988) Geographic patterns of childhood insulin-dependent diabetes mellitus. Diabetes 37: 1113-1119
5. Reunanen A, Åkerblom HK, Käär M-L (1982) Prevalence and ten-year (1970-1979) incidence of insulin-dependent diabetes mellitus in children and adolescents in Finland. Acta Paediatr Scand 71: 893-899
6. Christau B, Åkerblom HK, Joner G, Dahlqvist G, Ludvigsson J, Nerup J (1981) Incidence of childhood insulin-dependent diabetes mellitus in Denmark, Finland, Norway and Sweden. A workshop report. Acta Endocrinol 98 [Suppl 245]: 68-80
7. LaPorte RE, Tajima N, Åkerblom HK et al. (1985) Geographic differences in the risk of insulin-dependent diabetes mellitus: the importance of registries. Diabetes Care 8 [Suppl 1]: 101-107
8. Rewers M, LaPorte RE, King H, Tuomilehto J (on behalf of the DERI Study Group) (1988) Trends in the prevalence and incidence of diabetes: insulin-dependent diabetes mellitus in childhood. World Health Stat Q 41: 179-189
9. Thai AC, Eisenbarth GS (1993) Natural history of IDDM. Diabetes Rev 1: 1-14
10. Knip M (1997) Disease-associated autoimmunity and prevention of insulin-dependent diabetes mellitus. Ann Med 29: 447-451
11. Bertrams J, Baur MP (1984) Insulin-dependent diabetes mellitus. In: Albert ED, Baur MP, Mayr WR (eds) Histocompability testing. Springer, Berlin Heidelberg New York, pp 348-358
12. Davies J, Kawaguchi Y, Bennett ST et al. (1994) A genome wide search for human Type I diabetes susceptibility genes. Nature 371: 130-136
13. Rotter JI, Landaw EM (1984) Measuring the genetic contribution of a single locus to a multilocus disease. Clin Genet 26: 529-542
14. Pugliese A, Gianani R, Moromisato R et al. (1995) HLA-DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patients with IDDM. Diabetes 44: 608-613
15. Kulmala P, Savola K, Petersen J et al. (1998) Prediction of insulin-dependent diabetes mellitus in sibs of children with diabetes: a population-based study. J Clin Invest 101: 327-336
16. Bingley PJ, Christie MR, Bonifacio E et al. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes 43: 1304-1310
17. Verge CF, Gianini R, Kawasaki E et al. (1996) Prediction of Type I diabetes in first-degree relatives using a combination of insulin, GAD and ICA512bdc/IA-2 antibodies. Diabetes 45: 926-933
18. Baisch JM, Weeks T, Giles R, Hoover M, Stastny P, Capra JD (1990) Analysis of HLA-D genotypes and susceptibility in insulin-dependent diabetes mellitus. N Engl J Med 322: 1836-1841
19. Kupila A, Muona P, Simell T et al. (2001) Feasibility of genetic and immunological prediction of Type I diabetes in a population-based cohort. Diabetologia 44: 290-297
20. Sjöroos M, Iitiä A, Ilonen J, Reijonen H, Lövgren T (1995) Triple-label hybridization assay for Type I diabetes-related HLA alleles. Biotechniques 18: 870-877
21. Ilonen J, Reijonen H, Herva E et al. (1996) Rapid HLA-DQB1 genotyping for four alleles in the assessment of IDDM risk in the Finnish population. Diabetes Care 19: 795-800
22. Bottazzo GF, Florin-Christensen A, Doniach D (1974) Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet ii: 1279-1282
23. Williams AJK, Bingley PJ, Bonifacio E, Palmer JP, Gale EAM (1997) A novel micro-assay for insulin autoantibodies. J Autoimmun 10: 473-478
24. Verge CF, Stenger D, Bonifacio E et al. (1998) Combined use of autoantibodies (IA-2 antibody, GAD antibody, insulin antibody, cytoplasmic islet cell antibodies) in Type I diabetes. Combinatorial islet autoantibody workshop. Diabetes 47: 1857-1866
25. Savola K, Sabbah E, Kulmala P, Vähäsalo P, Ilonen J, Knip M (1998) Autoantibodies associated with Type I diabetes mellitus persist after diagnosis in children. Diabetologia 41: 1293-1297
26. Savola K, Bonifacio E, Sabbah E et al. (1998) IA-2 antibodies - a sensitive marker of IDDM with clinical onset in childhood and adolescence. Diabetologia 41: 424-429
27. Ziegler AG, Hummel M, Schenker M, Bonifacio E (1999) Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with Type I diabetes. Diabetes 48: 460-468
28. Kimpimäki T, Kupila A, Hämäläinen A-M et al. (2001) The first signs of β-cell autoimmunity appear in infancy in genetically susceptible children from the general population: The Finnish Type 1 Diabetes Prediction and Prevention Study. J Clin Endocrinol Metab 86: 8782-8788
29. Karjalainen J (1990) Islet cell antibodies as predictive markers for IDDM in children with high background incidence of disease. Diabetes 39: 1144-1150
30. Karjalainen J, Vähäsalo P, Knip M et al. (1996) Islet cell autoimmunity and progression to insulin-dependent diabetes mellitus in genetically high- and low-risk sibs of children. Eur J Clin Invest 26: 640-649
31. Karjalainen J, Salmela P, Ilonen J, Surcel HM, Knip M (1989) A comparison of childhood and adult Type I diabetes mellitus. N Engl J Med 320: 881-886
32. Thivolet C, Beaufree B, Geburher L, Chatelain P, Orgiazzi J (1991) Autoantibodies and genetic factors associated with the development of Type I (insulin-dependent) diabetes mellitus in first degree relatives of diabetic patients. Diabetologia 34: 186-191