Interleukin-6 expression after repeated bouts of eccentric exercise

International Journal of Sports Medicine

Volumn 24, Issue 1, 2003, Pages 15-21

  Willoughby, D S ^a   McFarlin, B ^a   Bois, C ^a  

^a TEXAS CHRISTIAN UNIVERSITY   (United States)

Author keywords

Immune response; Repeated bout effect

Indexed keywords

INTERLEUKIN 6; MESSENGER RNA; TROPONIN I;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; HUMAN; HUMAN EXPERIMENT; ISOTONIC EXERCISE; KNEE; MALE; MUSCLE FATIGUE; MUSCLE STRENGTH; NONPARAMETRIC TEST; NORMAL HUMAN; PROTEIN EXPRESSION;

ADULT; EXERCISE; HUMANS; INTERLEUKIN-6; MALE; MUSCLE, SKELETAL; PHYSICAL EDUCATION AND TRAINING; RNA, MESSENGER; TIME FACTORS; TROPONIN I;

EID: 0037284956     PISSN: 01724622     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-37197     Document Type: Article

References (31)

1. Aki T, Yanagisawa S, Akanuma H. Identification and characterization of positive regulatory elements in the human glyceraldehyde 3-phosphate dehydrogenase gene promoter. J Biochem 1997; 122: 217-228
2. Brown S, Child R, Day S, Donelly A. Indices of skeletal muscle damage and connective tissue breakdown following eccentric muscle contractions. Eur J Appl Physiol 1997; 75: 369-374
3. Bruunsgaard H, Galbo H, Halkjaer-Kristensen J, Johansen T, MacLean D, Pedersen B. Exercise-induced increase in serum interleukin-6 in humans is related to muscle damage. J Physiol 1997; 499.3: 833-841
4. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocynate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-159
5. Croisier J, Camus G, Venneman I, Deby-Dupont G, Juchmes-Ferir A, Lamy M, Crielaard J, Deby C, Duchateau J. Effects of training on exercise-induced muscle damage and interleukin-6 production. Muscle Nerve 1999; 22: 208-212
6. Ausubel F, Brent R, Kingston R, Moore D, Seidman J, Smith J, Struhl K. Current Protocols in Molecular Biology. Short Protocols in Molecular Biology. New York, NY: Wiley and Sons, 1999: pp. A3-10-A3-11
7. Ebisui C, Tsujinaka T, Morimoto T, Kan K, Iijima S, Yano M, Kominami E, Tanaka K, Monden M. Interleukin-6 induces proteolysis by activating intracellular proteases (cathepsons B and L, proteasome) in C2C12 myotubes. Clin Sci 1995; 89: 431-439
8. Goodman M. Interleukin-6 induces skeletal muscle protein breakdown in rats. Proc Soc Exp Biol Med 1994; 205: 182-185
9. Hortobagyi T, Houmard J, Fraser D, Dudek R, Lambert J, Tracy J. Normal forces and myofibrillar disruption after repeated eccentric exercise. J Appl Physiol 1998; 84: 492-498
10. Hyatt J, Clarkson P. Creatine kinase release and clearance using MM variants following repeated bouts of eccentric exercise. Med Sci Sports Exerc 1998; 30: 1059-1065
11. Jonsdottir I, Schjerling P, Ostrowski K, Asp S, Richter E. Muscle contractions induce interleukin-6 mRNA production in rat skeletal muscles. J Physiol 2000; 528: 157-163
12. Kayashima S, Ohono H, Fujioka T, Taniguchi N, Nagata N. Leucocytosis as a marker of organ damage induced by chronic strenuous physical exercise. Eur J Appl Physiol 1995; 70: 413-420
13. Kraemer W, Fry A. Strength testing: development and evaluation of methodology. In: Maud P, Foster C (eds.). Physiological Assessment of Human Fitness. Champaign, IL: Human Kinetics, 1995: pp. 115-133
14. Mair J, Koller A, Artner-Dworzak E, Haid C, Wicke K, Judmaier W, Puschendorf B. Effects of exercise on plasma myosin heavy chain fragments and MRI of skeletal muscle. J Appl Physiol 1992; 72: 656-663
15. Malm, C, Nyberg P, Engstrom M, Sjodin B, Lenkei R, Ekblom B, Lundberg I. Immunological changes in human skeletal muscle and blood after eccentric exercise and multiple biopsies. J Physiol 2000; 529: 243-262
16. Mayhew T, Rothstein J, Finucane S, Lamb R. Muscular adaptation to concentric and eccentric exercise at equal power levels. Med Sci Sports Exerc 1995; 27: 868-873
17. McHugh M, Connolly D, Eston R, Geim G. Exercise-induced muscle damage and potential mechanisms for the repeated bout effect. Sports Med 1999; 27: 157-170
18. Moldoveanu A, Shephard R, Shek P. Exercise elevates plasma levels but not gene expression of IL-1β, IL-6, and TNF-α in blood mononuclear cells. J Appl Physiol 2000; 89: 1499-1504
19. Nosaka K, Clarkson P. Muscle damage following repeated bouts of high force eccentric exercise. Med Sci Sports Exerc 1995; 27: 1263-1269
20. Ostrowski K, Hermann C, Bangash A, Schjerling P, Nielsen J, Pedersen B. A trauma-like elevation of plasma cytokines in humans in response to treadmill running. J Physiol 1998; 513:889-894
21. Ostrowski K, Rhode T, Zacho M, Asp S, Pedersen B. Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running. J Physiol 1998; 508: 949-953
22. Pedersen B, Ostrowski K, Rhode T, Bruunsgaard H. The cytokine response to exercise. Can J Physiol Pharmacol 1998; 76: 505-511
23. Puntschart A, Claassen H, Jostarndt K, Hoppeler H, Billeter R. mRNAs of enzymes involved in energy metabolism and mtDNA are increased in endurance-trained athletes. Am J Physiol 1995; 269: C619-625
24. Rhode T, MacLean D, Richter E, Kiens B, Pedersen B. Prolonged submaximal eccentric exercise is associated with increased levels of plasma IL-6. Am J Physiol 1997; 273: E85-E91
25. Sorichter S, Mair J, Koller A, Gebert W, Rama D, Calzolari C, Artner-Dworzak E, Puschendorf B. Skeletal troponin I as a marker of exercise-induced muscle damage. J Appl Physiol 1997; 83: 1076-1082
26. Sorichter S, Mair J, Koller A, Secnik P, Parrak V, Haid C, Muller E, Puschendorf B. Muscular adaptation and strength during the early phase of eccentric training: influence of training frequency. Med Sci Sports Exerc 1997; 29: 1646-1652
27. Steensberg A, van Hall G, Osada T, Sacchetti M, Saltin B, Pedersen B. Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increases in plasma interleukin-6. J Physiol 2000; 529: 237-242
28. Willoughby D, Pelsue S. Muscle strength and qualitative myosin heavy chain isoform mRNA expression after moderate-and high-intensity weight training in the elderly. J Aging Phys Act 1998; 6: 327-339
29. Willoughby D, Pelsue S. Effects of high-intensity strength training on steady-state myosin heavy chain mRNA expression. J Exer Physiol 2000; 3: 13-25
30. Willoughby D, Priest J, Jennings R. Myosin heavy chain isoform and ubiquitin protease mRNA expression after passive leg cycling in individuals with spinal cord injury. Arch Phys Med Rehab 2000; 81: 157-163
31. Willoughby D, Rosene J. Effects of oral creatine and heavy resistance training on myosin heavy chain expression. Med Sci Sports Exerc 2001; 33: 1674-1681