A trauma-like elevation of plasma cytokines in humans in response to treadmill running

Journal of Physiology

Volumn 513, Issue 3, 1998, Pages 889-894

  Ostrowski, Kenneth ^a   Hermann, Claus ^a   Bangash, Aimal ^a   Schjerling, Peter ^a   Nielsen, Jakob Nis ^a   Pedersen, Bente Klarlund ^a  

^a Rigshospitalet   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CYTOKINE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 15; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; TUMOR NECROSIS FACTOR ALPHA; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA;

ADULT; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; TREADMILL EXERCISE; CYTOKINE RESPONSE; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION;

ADULT; CHEMOKINES; CYTOKINES; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; KINETICS; MACROPHAGE INFLAMMATORY PROTEIN-1; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; RUNNING; TUMOR NECROSIS FACTOR-ALPHA; WOUNDS AND INJURIES;

EID: 0032535063     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1998.889ba.x     Document Type: Article

References (17)

1. BIFFL, W. L., MOORE, E. E., MOORE, F. A. & PETERSON, V. M. (1996). Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation? Annals of Surgery 224, 647-664.
2. BRUUNSGAARD, H., GALBO, H., HALKJAER, K. J., JOHANSEN, T. L., MACLEAN, D. A. & PEDERSEN, B. K. (1997). Exercise-induced increase in serum interleukin-6 in humans is related to muscle damage. Journal of Physiology 499, 833-841.
3. CASTELL, L. M., POORTMANS, J. R., LECLERCQ, R., BRASSEUR, M., DUCHATEAU, J. & NEWSHOLME, E. A. (1997). Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation. European Journal of Applied Physiology and Occupational Physiology 75, 47-53.
4. DERIJK, R. H., BOELEN, A., TILDERS, F. J. & BERKENBOSCH, F. (1994). Induction of plasma interleukin-6 by circulating adrenaline in the rat. Psychoneuroendocrinology 19, 155-163.
5. DILL, D. B. & COSTILL, D. L. (1974). Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. Journal of Applied Physiology 37, 247-248.
6. DRENTH, J. P., VAN UUM, S. H., VAN DEUREN, M., PESMAN, G. J., VAN DER VEN JONGEKRIJG, J. & VAN MEER, J. W. (1995). Endurance run increases circulating IL-6 and IL-1ra but downregulates ex vivo TNF-alpha and IL-1 beta production. Journal of Applied Physiology 79, 1497-1503.
7. JORDAN, M., OTTERNESS, I. G., NG, R., GESSNER, A., ROLLINGHOFF, M. & BEUSCHER, H. U. (1995). Neutralization of endogenous IL-6 suppresses induction of IL-1 receptor antagonist. Journal of Immunology 154, 4081-4090.
8. LIEBER, R. L., THORNELL, L. E. & FRIDEN, J. (1996). Muscle cytoskeletal disruption occurs within the first 15 min of cyclic eccentric contraction. Journal of Applied Physiology 80, 278-284.
9. MARTIN, C., BOISSON, C., HACCOUN, M., THOMACHOT, L. & MEGE, J. L. (1997). Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma. Critical Care Medicine 25, 1813-1819.
10. MUSTAFA, M. M., RAMILO, O., OLSEN, K. D., FRANKLIN, P. S., HANSEN, E. J., BEUTLER, B. & MCCRACKEN, G. H. JR (1989). Tumor necrosis factor in mediating experimental Haemophilus influenzae type B meningitis. Journal of Clinical Investigation 84, 1253-1259.
11. NEHLSEN-CANNARELLA, S. L., FAGOAGA, O. R., NIEMAN, D. C., HENSON, D. A., BUTTERWORTH, D. E., SCHMITT, R. L., BAILEY, E. M., WARREN, B. J., UTTER, A. & DAVIS, J. M. (1997). Carbohydrate and the cytokine response to 2·5 h of running. Journal of Applied Physiology 82, 1662-1667.
12. OSTROWSKI, K., ROHDE, T., ZACHO, M., ASP, S. & PEDERSEN, B. K. (1998). Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running. Journal of Physiology 508, 949-953.
13. ROUMEN, R. M., HENDRIKS, T., VAN DER VEN JONGEKRIJG, J., NIEUWENHUIJZEN, G. A., SAUERWEIN, R. W., VAN DER MEER, J. & GORIS, R. J. (1993). Cytokine patterns in patients after major vascular surgery, hemorrhagic shock, and severe blunt trauma. Relation with subsequent adult respiratory distress syndrome and multiple organ failure. Annals of Surgery 218, 769-776.
14. SPRENGER, H., JACOBS, C., NAIN, M., GRESSNER, A. M., PRINZ, H., WESEMANN, W. & GEMSA, D. (1992). Enhanced release of cytokines, interleukin-2 receptors, and neopterin after long-distance running. Clinical Immunology and Immunopathology 63, 188-195.
15. SVOBODA, P., KANTOROVA, I. & OCHMANN, J. (1994). Dynamics of interleukin 1, 2, and 6 and tumor necrosis factor alpha in multiple trauma patients. Journal of Trauma 36, 336-340.
16. TILG, H., TREHU, E., ATKINS, M. B., DINARELLO, C. A. & MIER, J. W. (1994). Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55. Blood 83, 113-118.
17. WAAGE, A., HALSTENSEN, A., SHALABY, R., BRANDTZAEG, P., KIERULF, P. & ESPEVIK, T. (1989). Local production of tumor necrosis factor alpha, interleukin 1, and interleukin 6 in meningococcal meningitis. Relation to the inflammatory response. Journal of Experimental Medicine 170, 1859-1867.