Resolving the composite trait of hypertension into its pharmacogenetic determinants by acute pharmacological modulation of blood pressure regulatory systems

Journal of Molecular Medicine

Volumn 81, Issue 1, 2003, Pages 51-60

  Ueno, Takahiro ^a   Tremblay, Johanne ^a   Kunes, Jaroslav ^b   Zicha, Josef ^b   Dobesova, Zdenka ^b   Pausova, Zdenka ^a   Deng, Alan Y ^a   Sun, Yu Lin ^a   Jacob, Howard J ^c   Hamet, Pavel ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Nitric oxide system; Prague hypertensive hypertriglyceridemic rat; Quantitative trait locus; Renin angiotensin system; Sympathetic nervous system

Indexed keywords

LOSARTAN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PENTOLONIUM TARTRATE;

ADRENERGIC SYSTEM; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; CHROMOSOME 1; CHROMOSOME 3; CHROMOSOME 5; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GENE MAPPING; GENETIC LINKAGE; GENOTYPE; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PHARMACOGENETICS; QUANTITATIVE TRAIT LOCUS; RAT; RAT STRAIN; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

EID: 0037280308     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-002-0394-7     Document Type: Article

References (39)

1. Jacob HJ, Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao YP, Ganten D, Dzau VJ, Lander ES (1991) Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell 67:213-224
2. Deng Y, Rapp JP (1992) Cosegregation of blood pressure with angiotensin converting enzyme and atrial natriuretic peptide receptor genes using Dahl salt-sensitive rats. Nat Genet 1:267-272
3. Deng AY, Dene H, Rapp JP (1994) Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. J Clin Invest 94:431-436
4. Stoll M, Cowley AW Jr, Tonellato PJ, Greene AS, Kaldunski ML, Roman RJ, Dumas P, Schork NJ, Wang Z, Jacob HJ (2001) A genomic-systems biology map for cardiovascular function. Science 294:1723-1726
5. Clark JS, Jeffs B, Davidson AO, Lee WK, Anderson NH, Bihoreau MT, Brosnan MJ, Devlin AM, Kelman AW, Lindpaintner K, Dominiczak AF (1996) Quantitative trait loci in genetically hypertensive rats: possible gender specificity. Hypertension 28:898-906
6. Garrett MR, Dene H, Walder R, Zhang QY, Cicila GT, Assadnia S, Deng AY, Rapp JP (1998) Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats. Genome Res 8:7711-7723
7. Hamet P, Pausova Z, Adarichev S, Adaricheva K, Tremblay J (1998) Hypertension: genes and environment. J Hypertens 16:397-418
8. Dumas P, Pausova Z, Kren V, Krenova D, Pravenec M, Dumont M, Ely D, Turner M, Sun Y, Tremblay J, Hamet P (2000) Contribution of autosomal loci and the Y chromosome to the stress response in rat. Hypertension 35:2568-2573
9. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B (1997) A model for p53-induced apoptosis. Nature 389:6648300-6648305
10. Mashimo T, Nabika T, Matsumoto C, Tamada T, Ueno K, Sawamura M, Ikeda K, Kato N, Nara Y, Yamori Y (1999) Aging and salt-loading modulate blood pressure QTLs in rats. Am J Hypertens 12:1098-1104
11. Yagil C, Sapojnikov M, Kreutz R, Katni G, Lindpaintner K, Ganten D, Yagil Y (1998) Salt susceptibility maps to chromosomes 1 and 17 with sex specificity in the Sabra rat model of hypertension. Hypertension 31:1119-1124
12. Yagil C, Sapojnikov M, Kreutz R, Zurcher H, Ganten D, Yagil Y (1999) Role of chromosome X in the Sabra rat model of salt-sensitive hypertension. Hypertension 33:261-265
13. Iwai N, Tsujita Y, Kinoshita M (1998) Isolation of a chromosome 1 region that contributes to high blood pressure and salt sensitivity. Hypertension 32:4636-4638
14. Vincent M, Samani NJ, Gauguier D, Thompson JR, Lathrop GM, Sassard J (1997) A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. A chromosome 2 locus influences the response to a calcium antagonist. J Clin Invest 100:2000-2006
15. Vrana A, Kazdova L (1990) The hereditary hypertriglyceridemic nonobese rat: an experimental model of human hypertriglyceridemia. Transplant Proc 22:2579
16. Stolba P, Dobesova Z, Husek P, Opltova H, Zicha J, Vrana A, Kunes J (1992) The hypertriglyceridemic rat as a genetic model of hypertension and diabetes. Life Sci 51:733-740
17. Vrana A, Kazdova L, Dobesova Z, Kunes J, Kren V, Bila V, Stolba P, Klimes I (1993) Triglyceridemia, glucoregulation, and blood pressure in various rat strains. Effects of dietary carbohydrates. Ann NY Acad Sci 683:57-68
18. Stolba P, Opltova H, Husek P, Nedvidkova J, Kunes J, Dobesova Z, Nedvidek J, Vrana A (1993) Adrenergic overactivity and insulin resistance in nonobese hereditary hypertriglyceridemic rats. Ann NY Acad Sci 683:281-288
19. Kunes J, Dobesova Z, Zicha J (2002) Altered balance of main vasopressor and vasodepressor systems in rats with genetic hypertension and hypertriglyceridaemia. Clin Sci (Colch) 102:269-277
20. Almasy L, Blangero J (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211
21. Darvasi A, Soller M (1995) Advanced intercross lines, an experimental population for fine genetic mapping. Genetics 141:1199-1207
22. Darvasi A, Soller M (1992) Selective genotyping for determination of linkage between a marker locus and a quantitative trait locus. Theor Appl Genet 85:353-359
23. Darvasi A (1997) The effect of selective genotyping on QTL mapping accuracy. Mamm Genome 8:67-68
24. Deng AY, Dene H, Pravenec M, Rapp JP (1994) Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. J Clin Invest 93: 2701-2709
25. Manly KF, Olson JM (1999) Overview of QTL mapping software and introduction to map manager QT. Mamm Genome 10:327-334
26. Matsumoto C, Nara Y, Ikeda K, Tamada T, Mashimo T, Nabika T, Sawamura M, Yamori Y (1996) Cosegregation of the new region on chromosome 3 with salt-induced hypertension in female F2 progeny from stroke-prone spontaneously hypertensive and Wistar-Kyoto rats. Clin Exp Pharmacol Physiol 23:1028-1034
27. Cicila GT, Choi C, Dene H, Lee SJ, Rapp JP (1999) Two blood pressure/cardiac mass quantitative trait loci on chromosome 3 in Dahl rats. Mamm Genome 10:112-116
28. Li P, Morris M, Diz DI, Ferrario CM, Ganten D, Callahan MF (1996) Role of paraventricular angiotensin AT1 receptors in salt-sensitive hypertension in mRen-2 transgenic rats. Am J Physiol 270:R1178-R1181
29. Miyajima E, Yamada Y (1999) Reduced sympathetic inhibiion in salt-sensitive Japanese young adults. Am J Hypertens 12:1195-1200
30. Fujiwara N, Osanai T, Kamada T, Katoh T, Takahashi K, Okumura K (2000) Study on the relationship between plasma nitrite and nitrate level and salt sensitivity in human hypertension: modulation of nitric oxide synthesis by salt intake. Circulation 101:856-861
31. Kren V, Pravenec M, Lu S, Krenova D, Wang JM, Wang M, Merriouns T, Wong A, St. Lezin E, Lau D, Szpirer C, Szpirer J, Kurtz TW (1997) Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat. J Clin Invest 99:577-581
32. De Champlain J (1990) Pre- and postsynaptic adrenergic dysfunctions in hypertension. J Hypertens Suppl 8:S77-S85
33. Laflamme A, Wu L, Foucart S, De Champlain J (1998) Impaired basal sympathetic tone and alpha1-adrenergic responsiveness in association with the hypotensive effect of melatonin in spontaneously hypertensive rats. Am J Hypertens 11:219-229
34. Truett GE, Jacob HJ, Miller J, Drouin G, Bahary N, Smoller JW, Lander ES, Leibel RL (1995) Genetic map of rat chromosome 5 including the fatty (fa) locus. Mamm Genome 6:25-30
35. Morgan DA, Anderson EA, Mark AL (1995) Renal sympathetic nerve activity is increased in obese Zucker rats. Hypertension 25:834-838
36. Carlson SH, Shelton J, White CR, Wyss JM (2000) Elevated sympathetic activity contributes to hypertension and salt sensitivity in diabetic obese Zucker rats. Hypertension 35:403-408
37. Coleman DL (1982) Thermogenesis in diabetes-obesity syndromes in mutant mice. Diabetologia 22:205-211
38. Young JB, Landsberg L (1983) Diminished sympathetic nervous system activity in genetically obese (ob/ob) mouse. Am J Physiol 245:E148-E154
39. Turner ST, Schwartz GL, Chapman AB, Hall WD, Boerwinkle E (2001) Antihypertensive pharmacogenetics: getting the right drug into the right patient. J Hypertens 19:1-11