Caveats for the use of humerus length in the prediction of fetal Down syndrome

Fetal Diagnosis and Therapy

Volumn 18, Issue 3, 2003, Pages 190-195

  Vergani, Patrizia ^a   Locatelli, Anna ^a   Ghidini, Alessandro ^b   Mariani, Eloisa ^a   Strobelt, Nicola ^a   Biffi, Anna ^a   Pezzullo, John C ^b  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b GEORGETOWN UNIVERSITY HOSPITAL   (United States)

Author keywords

Humerus length; Prenatal diagnosis; Trisomy 21; Ultrasonography

Indexed keywords

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DOWN SYNDROME; FETUS; FETUS DISEASE; FETUS ECHOGRAPHY; GENETIC RISK; HIGH RISK POPULATION; HORMONE BLOOD LEVEL; HUMAN; HUMERUS; MEDLINE; PREDICTION; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RECEIVER OPERATING CHARACTERISTIC; RELIABILITY; REPRODUCIBILITY; STUDENT T TEST; TRISOMY 21;

ADULT; ALGORITHMS; CASE-CONTROL STUDIES; COHORT STUDIES; DOWN SYNDROME; FALSE POSITIVE REACTIONS; FEMALE; HUMANS; HUMERUS; INFANT, NEWBORN; MALE; PREGNANCY; REPRODUCIBILITY OF RESULTS; ULTRASONOGRAPHY, PRENATAL;

EID: 0037275612     PISSN: 10153837     EISSN: None     Source Type: Journal    
DOI: 10.1159/000069376     Document Type: Article

References (30)

1. Vintzileos AM, Campbell WA, Guzman ER, Smulian JC, McLean DA, Ananth CV: Second-trimester ultrasound markers for detection of trisomy 21: Which markers are best? Obstet Gynecol 1997;89:941-944.
2. Bahado-Singh RO, Deren O, Oz AU, Tan A, Hunter D, Copel J: An alternative for women initially declining genetic amniocentesis: Individual Down syndrome odds on the basis of maternal age and multiple ultrasonographic markers. Am J Obstet Gynecol 1998;179:514-519.
3. Vergani P, Locatelli A, Piccoli MG, Mariani E, Strobelt N, Pezzullo JC, Ghidini A: Critical reappraisal of the utility of sonographic fetal femur length in the prediction of trisomy 21. Prenat Diagn 2000;20:210-214.
4. Benacerraf BR, Neuberg D, Frigoletto FD: Humeral shortening in second-trimester fetuses with Down syndrome. Obstet Gynecol 1991;77:223-226.
5. Benacerraf BR, Neuberg D, Bromley B, Frigoletto FD: Sonographic scoring index for prenatal detection of chromosomal abnormalities. J Ultrasound Med 1992;11:449-458.
6. Benacerraf BR, Nadel A, Bromley B: Identification of second-trimester fetuses with autosomal trisomy by use of a sonographic scoring index. Radiology 1994;193:135-140.
7. Nyberg DA, Resta RG, Luthy DA, Durlin EH, Williams MA: Humerus and femur length shortening in detection of Down's syndrome. Am J Obstet Gynecol 1993;168:534-538.
8. Nyberg DA, Luthy DA, Resta RG, Nyberg BC, Williams MA: Age-adjusted ultrasound risk assessment for fetal Down's syndrome during the second trimester: Description of the method and analysis of 142 cases. Ultrasound Obstet Gynecol 1998;12:8-14.
9. Vintzileos AM, Egan JFX: Adjusting the risk for trisomy 21 on the basis of second trimester ultrasonography. Am J Obstet Gynecol 1995;172:837-844.
10. Vintzileos AM, Egan JF, Smullian JC, Campell WA, Guzman E, Rodis JF: Adjusting the risk for trisomy 21 by a simple ultrasound method using fetal long-bone biometry. Obstet Gynecol 1996;87:953-958.
11. Vintzileos AM, Campbell WA, Rodis JF, Guzman ER, Smulian JC, Knuppel RA: The use of second-trimester genetic sonogram in guiding clinical management of patients at increased risk for fetal trisomy 21. Obstet Gynecol 1996;87:948-952.
12. Bromley B, Shipp T, Benacerraf BR: Genetic sonogram scoring index: Accuracy and clinical utility. J Ultrasound Med 1999;18:523-528.
13. Johnson MP, Michaelson JE, Barr M, Treadwell MC, Hume RF, Dombrowski MP, Evans MI: Combining humerus and femur length for improved ultrasonographic identification of pregnancies at increased risk for trisomy 21. Am J Obstet Gynecol 1995;172:1229-1235.
14. Bahado-Singh RO, Oz AU, Kovanci E, Deren O, Copel J, Baumgarten A, Mahoney MJ: New Down syndrome screening algorithm: Ultrasonographic biometry and multiple serum markers combined with maternal age. Am J Obstet Gynecol 1998;179:1627-1631.
15. Bahado-Singh RO, Oz AU, Gomez K, Hunter D, Copel J; Baumgarten A, Mahoney MJ: Combined ultrasound biometry, serum markers and age for Down syndrome risk estimation. Ultrasound Obstet Gynecol 2000;15:199-204.
16. Bahado-Singh RO, Oz U, Hsu CD, Deren O, Copel J, Mahoney MJ: Ratio of nuchal thickness to humerus length for Down syndrome detection. Am J Obstet Gynecol 2001;184:1284-1288.
17. Deren O, Mahoney MJ, Copel JA, Bahado-Singh RO: Subtle ultrasonographic anomalies: Do they improve the Down syndrome detection rate? Am J Obstet Gynecol 1998;178:441-445.
18. Rodis JF, Vintzileos AM, Fleming AD, Ciarleglio L, Nardi A, Scorza WE: Comparison of humerus length with femur length in fetuses with Down syndrome. Am J Obstet Gynecol 1991;165:1051-1056.
19. Rotmensch S, Luo JS, Liberati M, Belanger K, Mahoney MJ, Hobbins JC: Fetal humeral length to detect Down syndrome. Am J Obstet Gynecol 1992;166:1330-1334.
20. Lockwood C, Lynch L, Ghidini A, Lapinski R, Berkowitz G, Thayer B: The effect of fetal gender on the prediction of Down syndrome by means of maternal serum-fetoprotein and ultrasonographic parameters. Am J Obstet Gynecol 1993;169:1190-1197.
21. Biagiotti R, Periti E, Cariati E: Humerus and femur length in fetuses with Down syndrome. Prenat Diagn 1994;14:429-434.
22. Bahado-Singh RO, Deren O, Tan A, Levi D'Ancona R, Hunter D, Copel J, Mahoney MJ: Ultrasonographically adjusted midtrimester risk of trisomy 21 and significant chromosomal defects in advanced maternal age. Am J Obstet Gynecol 1996;175:1563-1568.
23. Bromley B, Lieberman E, Benacerraf BR: The incorporation of maternal age into the sonographic scoring index for detection at 14-20 weeks of fetuses with Down's syndrome. Ultrasound Obstet Gynecol 1997;10:321-324.
24. Borrell A, Costa D, Martinez JM, Seres A, Margarit E, Fortuny A: Limited effectiveness of femur and humerus shortening as markers of Down syndrome in early midtrimester fetuses. Fetal Diagn Ther 1997;12:156-162.
25. Winter TC, Uhrich SB, Souter VL, Nyberg DA: The 'genetic sonogram': Comparison of the index scoring system with the age-adjusted US risk assessment. Radiology 2000;215:775-782.
26. Nyberg DA, Souter VL, El-Bastawissi A, Young S, Luthhardt F, Luthy DA: Isolated sonographic markers for detection of fetal Down syndrome in the second trimester of pregnancy. J Ultrasound Med 2001;20:1053-1063.
27. Pinette MG, Garrett J, Salvo A, Blackstone J, Pinette SG, Boutin N, Cartin A: Normal midtrimester (17-20 weeks) genetic sonogram decreases amniocentesis rate in a high-risk population. J Ultrasound Med 2001;20:639-644.
28. Viora E, Errante G, Bastonero S, Sciarrone A, Campogrande M: Minor sonographic signs of trisomy 21 at 15-20 weeks' gestation in fetuses born without malformations: A prospective study. Prenat Diagn 2001;21:1163-1166.
29. Smith-Bindman R, Hosmer W, Feldstein VA, Deeks JJ, Goldberg JD: Second trimester ultrasound to detect fetuses with Down syndrome. JAMA 2001;285:1044-1055.
30. Bahado-Singh RO, Tan A, Deren O, Hunter D, Copel J, Mahoney MJ: Risk of Down syndrome and any clinically significant chromosome defect in pregnancies with abnormal triple-screen and normal targeted ultrasonographic results. Am J Obstet Gynecol 1996;175:824-829.