Critical reappraisal of the utility of sonographic fetal femur length in the prediction of trisomy 21

Prenatal Diagnosis

Volumn 20, Issue 3, 2000, Pages 210-214

  Vergani, Patrizia ^a   Locatelli, Anna ^a   Piccoli, Maria Giovanna ^a   Mariani, Eloisa ^a   Strobelt, Nicola ^a   Pezzullo, John C ^b   Ghidini, Alessandro ^b  

^a Div di Ostetricia e Ginecologia   (Italy)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Prenatal diagnosis; Trisomy 21; Ultrasonography

Indexed keywords

ADULT; ARTICLE; DEVICE; DIAGNOSTIC VALUE; DOWN SYNDROME; FEMALE; FEMUR; FETUS; FETUS ECHOGRAPHY; GESTATIONAL AGE; HUMAN; MAJOR CLINICAL STUDY; MORPHOMETRICS; PREDICTION; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; REGRESSION ANALYSIS; TRISOMY 21;

ADULT; DOWN SYNDROME; FEMALE; FEMUR; GESTATIONAL AGE; HUMANS; MIDDLE AGED; PREGNANCY; ULTRASONOGRAPHY, PRENATAL;

EID: 0034025981     PISSN: 01973851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0223(200003)20:3<210::AID-PD784>3.0.CO;2-4     Document Type: Article

References (37)

1. Bahado-Singh RO, Deren O, Oz AU, Tan A, Hunter D, Copel J. 1998. An alternative for women initially declining genetic amniocentesis: individual Down syndrome odds on the basis of maternal age and multiple ultrasonographic markers. Am J Obstet Gynecol 179: 514-519.
2. Benacerraf BR, Gelman R, Frigoletto FD. 1987. Sonographic identification of second trimester fetuses with Down's syndrome. N Engl J Med 317: 1371-1376.
3. Benacerraf BR, Cnann A, Gelman R, Laboda LA, Frigoletto FD. 1989. Can sonographers reliably identify anatomy features associated with Down syndrome in fetuses? Radiology 173: 377-380.
4. Benacerraf BR, Neuberg D, Bromley B, Frigoletto FD. 1992. Sonographic scoring index for prenatal detection of chromosomal abnormalities. J Ultrasound Med 11: 449-458.
5. Benacerraf BR, Nadel A, Bromley B. 1994. Identification of second-trimester fetuses with autosomal trisomy by use of a sonographic scoring index. Radiology 193: 135-140.
6. Bromley B, Lieberman E, Benacerraf BR. 1997. The incorporation of maternal age into the sonographic scoring index for detection at 14-20 weeks of fetuses with Down's syndrome. Ultrasound Obstet Gynecol 10: 321-324.
7. Brumfield CG, Hauth JC, Cloud GA, Davis RO, Henson BV, Cosper P. 1989. Sonographic measurements and ratios in fetuses with Down syndrome. Obstet Gynecol 73: 644-646.
8. Campbell WA, Vintzileos AM, Rodis JF, Ciarleglio L, Craffey A. 1994. Efficacy of the biparietal diameter/femur length ratio to detect Down syndrome in patients with an abnormal biochemical screen. Fetal Diagn Ther 9: 175-182.
9. Cuckle H. Wald N, Quinn J, Royston P, Butler L. 1989. Ultrasound fetal femur length measurement in the screening for Down's syndrome. Br J Obstet Gynaecol 96: 1373-1378.
10. Deren O, Mahoney MJ, Copel JA, Bahado-Singh RO. 1998. Subtle ultrasonographic anomalies: do they improve the Down syndrome detection rate? Am J Obstet Gynecol 178: 441-445.
11. Dicke JM, Gray DL, Songster GS. Crane JP. 1989. Fetal biometry as a screening tool for the detection of chromosomally abnormal pregnancies. Obstet Gynecol 74: 726-729.
12. Ginsberg N, Cadkin A, Pergament E, Verlinsky Y. 1990. Ultrasonographic detection of the second-trimester fetus with trisomy 18 and trisomy 21. Am J Obstet Gynecol 163: 1186-1190.
13. Grandjean H, Sarramon MF. 1995. Femur/foot length ratio for detection of Down syndrome: result of a multicenter prospective study. Am J Obstet Gynecol 173: 16-19.
14. Hadlock FP, Harrist RB, Martinez-Poyer J. 1992. Fetal body ratios in second trimester, a useful tool for identifying chromosomal abnormalities? J Ultrasound Med 11:81-85.
15. Hill LM, Guzick D, Belfar HL, Hixson J, Rivello D, Rusnak J. 1989. The current role of sonography in the detection of Down syndrome. Obstet Gynecol 74: 620-623.
16. Johnson MP, Michaelson JE, Barr M, Treadwell MC. Hume RF, Dombrowski MP. 1995. Combining humerus and femur length for improved ultrasonographic identification of pregnancies at increased risk for trisomy 21. Am J Obstet Gynecol 172: 1229-1235.
17. LaFollette L, Filly RA, Anderson R, Golbus MS. 1989. Fetal femur length to detect trisomy 21. J Ultrasound Med 8: 657-660.
18. Lockwood C, Benacerraf B, Krinsky A, Blakemore K, Belanger K, Mahoney M. 1987. A sonographic screening method for Down syndrome. Am J Obstet Gynecol 157: 803-808.
19. Lockwood C, Lynch L, Ghidini A, Lapinski R, Berkowitz G, Thayer B. 1993. The effect of fetal gender on the prediction of Down syndrome by means of maternal serum α-fetoprotein and ultrasonographic parameters. Am J Obstet Gynecol 169: 1190-1197.
20. Lynch J, Berkowitz GS, Chitkara U, Wilkins IA, Mehalek KE, Berkowitz RL. 1989. Ultrasound detection of Down syndrome: is it really possible? Obstet Gynecol 73: 267-270.
21. Marquette GP, Boucher M, Desrochers M, Dallaire L. 1990. Screening for trisomy 21 with ultrasonographic determination of biparietal diameter/femur length ratio. Am J Obstet Gynecol 163: 1604-1605.
22. Nadel AS, Bromley B, Frigoletto FD, Benacerraf BR. 1995. Can the presumed risk of autosomal trisomy be decreased in fetuses of older women following a normal sonogram? J Ultrasound Med 14: 297-302.
23. Nyberg DA, Resta RG, Hickok DE, Hollenback KA, Luthy DA, Mahony BS. 1990. Femur length shortening in the detection of Down syndrome. Is prenatal screening feasible? Am J Obstet Gynecol 162: 1247-1252.
24. Nyberg DA, Resta RG, Luthy DA, Durlin EH, Williams MA. 1993. Humerus and femur length shortening in detection of Down's syndrome. Am J Obstet Gynecol 168: 534-538.
25. Nyberg DA, Luthy DA, Resta RG, Nyberg BC, Williams MA. 1998. Age-adjusted ultrasound risk assessment for fetal Down's syndrome during the second trimester: description of the method and analysis of 142 cases. Ultrasound Obstet Gynecol 12: 8-14.
26. Perrella R, Duerinckx AJ, Grant E, Tesler F, Tabsh K, Crandall BF. 1988. Second-trimester sonographic diagnosis of Down syndrome: role of femur-length shortening and nuchal-fold thickening. AJR 151: 981-985.
27. Peters MT, Lockwood CJ, Miller WA. 1989. The efficacy of fetal sonographic biometry in Down syndrome screening. Am J Obstet Gynecol 161: 297-300.
28. Platt LD, Medearis AL, Carlson DE, Falk RE, DeVore GR, Horenstein J. 1992. Screening for Down syndrome with the femur length/biparietal diameter ratio: a new twist of the data. Am J Obstet Gynecol 167: 124-128.
29. Rodis JF, Vintzileos AM, Fleming AD, Ciarleglio L, Nardi A, Scorza WE. 1991. Comparison of humerus length with femur length in fetuses with Down syndrome. Am J Obstet Gynecol 165: 1051-1056.
30. Rotmensch S, Luo JS, Liberati M, Belanger K, Mahoney MJ, Hobbins JC. 1992. Fetal humeral length to detect Down syndrome. Am J Obstet Gynecol 166: 1330-1334.
31. Shah YG, Eckl CJ, Stinson SK, Woods JR. 1990. Biparietal diameter/femur length ratio, cephalic index, and femur length measurements, not reliable screening techniques for Down syndrome. Obstet Gynecol 75: 186-188.
32. Verdin SM, Economides DL. 1998. The role of ultrasonographic markers for trisomy 21 in women with positive serum biochemistry. Br J Obstet Gynaecol 105: 63-67.
33. Vintzileos AM, Egan JFX. 1995. Adjusting the risk for trisomy 21 on the basis of second trimester ultrasonography. Am J Obstet Gynecol 172: 837-844.
34. Vintzileos AM, Egan JF, Smullian JC, Campbell WA, Guzman E, Rodis JF. 1996a. Adjusting the risk for trisomy 21 by a simple ultrasound method using fetal long-bone biometry. Obstet Gynecol 87: 953-958.
35. Vintzileos AM, Campbell WA, Rodis JF, Guzman ER, Smulian JC, Knuppel RA. 1996b. The use of second-trimester genetic sonogram in guiding clinical management of patients at increased risk for fetal trisomy 21. Obstet Gynecol 87: 948-952.
36. Vintzileos AM, Campbell WA, Guzman ER, Smulian JC, McLean DA. 1997. Second-trimester ultrasound markers for detection of trisomy 21: Which markers are best? Obstet Gynecol 89: 941-944.
37. Winston YE, Horger EO. 1988. Down syndrome and femur length. Am J Obstet Gynecol 159: 1018.