Limited effectiveness of femur and humerus shortening as markers of down syndrome in early midtrimester fetuses

Fetal Diagnosis and Therapy

Volumn 12, Issue 3, 1997, Pages 156-162

  Borrell, Antoni ^a   Costa, Dolors ^b   Ojuel, Julia ^b   Martinez, Josep M ^a   Serés, Agustí ^a   Margarit, Ester ^b   Fortuny, Albert ^a  

^a Prenatal Diagnosis Unit   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Down syndrome; Femur shortening; Humerus shortening; Prenatal diagnosis; Ultrasonography

Indexed keywords

ADULT; AMNIOCENTESIS; ARTICLE; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DOWN SYNDROME; FEMALE; FEMUR; FETUS ECHOGRAPHY; HUMAN; HUMAN EXPERIMENT; HUMERUS; KARYOTYPE; NORMAL HUMAN; PREDICTION; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; SECOND TRIMESTER PREGNANCY;

EID: 0030851080     PISSN: 10153837     EISSN: 14219964     Source Type: Journal    
DOI: 10.1159/000264458     Document Type: Article

References (23)

1. Lockwood C, Benaccrraf B, Krinsky A, et al: A sonographic screening method for Down syndrome. Am J Obstet Gynecol 1987; 157:803-808.
2. Fitz Simmons J, Droste S, Shepard TH, Pascoe-Mason J, Chinn A, Mack LA: Long-bone grow th in fetuses with Down syndrome. Am J Obstet Gynecol 1989; 161:1174-1174.
3. Nyberg DA, Resta RG, Luthy DA, Hickok DE, Mahony BS, Hirsch JH: Prenatal sonographic findings of Down syndrome: Review of 94 cases. Obstet Gynecol 1980;76:370-377.
4. Wald NJ, Cuckle HS, Densem JW, et al: Maternal serum screening for Down's syndrome in early pregnancy. Br Med J 1988;297:883-887.
5. Benaccrraf BR, Barss VA, Laboda L: A sonographic sign for the detection in the second trimester of the fetus with Dow n syndrome. Am J Obstet Gynecol 1985;151:1078-1079.
6. Benaccrraf BR, Gelman R, Frigoletto FD: Sonographic identification of second-trimester fetuses with Down syndrome. N Engl J Med 1987;317:1371-1376.
7. EUROCAT Working Group: Report 5: Surveillance of Congenital Anomalies 1980-1990. Brussels: Institute of Hygiene and Epidemiology, 1993, p 145.
8. Rodis JF, Vintzilcos AM, Fleming AD, et al: Comparison of humerus length with femur length in fetuses with Down syndrome. Am J Obstet Gynecol 1991;165:1051-1056.
9. Peters MT, Lockwood CJ, Miller WA: The efficacy of fetal sonographic biometry in Down syndrome screening. Am J Obstet Gynecol 1989;161:297-300.
10. Cuckle H. Wald N, Quinn J, Royston P. Butler L: Ultrasound fetal femur length measurement in the screening for Down's syndrome. Br J Obstet Gynaecol 1989;96:1373-1378.
11. Dicke JM, Gray DL, Songster GS, Crane JP: Fetal biometry' as a screening tool for the detection of chromosomally abnormal pregnancies. Obstet Gynecol 1989;74:726-729.
12. Lynch L, Berkowitz GS, Chitkara U, Wilkins IA, Mchalck KE, Berkowitz RL: Ultrasound detection of Down syndrome: Is it really possible? Obstet Gynecol 1989;73:267-270.
13. Nyberg DA, Resta G, Hickok DE, Hollenbach KA, Luthy DA, Mahony BS: Femur shortening in the detection of Down syndrome: Is prenatal screening feasible? Am J Obstet Gynecol 1990; 162:1247-1252.
14. Shah YG, Eckl CJ, Stinson SK. Woods JR: Biparietal diameter/femur length ratio, cephalic index, and femur length measurements: Not reliable screening techniques for Down syndrome. Obstet Gynecol 1990;75:186-188.
15. Benacerraf BR, Neuberg D, Frigoletto FD: Humeral shortening in second-trimester fetuses with Down syndrome. Obstet Gynecol 1991; 77:223-227.
16. Rotmcnsch S, Luo J-S, Liberati M, Belanger K, Mahoney MJ, Hobbins JC: Fetal humeral length to detect Down syndrome. Am J Obstct Gynecol 1992:166:1330-1334.
17. Nyberg DA, Resta RG, Luthy DA, Hickok DE, Williams MA: Humerus and femur shortening in the detection of Down syndrome. Am J Obstet Gynecol 1993,168:534-538.
18. Biagiotti R, Periti E, Cariati E: Humerus and femur length in fetuses with Down syndrome. Prenat Diagn 1994;14:429-434.
19. Campbell WA, Vintzilcos AM, Rodis JF, Ciar-leglio L, Craffey A: Efficacy of the biparietal diameter/femur length ratio to detect Down syndrome in patients with an abnormal biochemical screen. Fetal Diagn Ther 1994:9:175-182.
20. Johnson MP, Michaelson JE, Barr M, et al: Combining humerus and femur length for improved ultrasonographic identifications of pregnancies at increased risk for trisomy 21. Am J Obstet Gynecol 1995; 172:1229-1235.
21. Borrcll A, Costa C, Martinez JM, et al: Early midtrimester fetal nuchal thickness: Effectiveness as a marker of Down syndrome. Am J Obstet Gynecol 1996;175:45-49.
22. Owen J, Wenstrom KD, Hardin JM, et al: The utility of fetal biometry as an adjunct to the multiple-markcr screening test for Down syndrome. Am J Obstet Gynecol 1994; 171:1041-1046.
23. Vintzileos AM, Egan JFX, Smulian JC, Campbell WA, Guzman ER, Rodis JF: Adjusting the risk for trisomy 21 by a simple ultrasound method using fetal long-bone biometry. Obstet Gynecol 1996;87:953-958.