Pharmacological evidence that tetraethylammonium-sensitive, iberiotoxin-insensitive K+ channels function as a negative feedback element for sympathetic neurotransmission by suppressing ω-conotoxin-GVIA-insensitive Ca2+ channels in the relaxation of rabbit facial vein

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 367, Issue 1, 2003, Pages 35-42

  Tanaka, Yoshio ^a   Akutsu, Aya ^a   Tanaka, Hikaru ^a   Horinouchi, Takahiro ^a   Tsuru, Hiromichi ^b   Koike, Katsuo ^a   Shigenobu, Koki ^a  

^a TOHO UNIVERSITY   (Japan)

^b TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

N type Ca2+ channel; Q type Ca2+ channel; Rabbit facial vein; Sympathetic nerve transmission; Tetraethylammonium; Voltage dependent and Ca2+ activated K+ (BKCa) channel

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; CHARYBDOTOXIN; GUANETHIDINE; IBERIOTOXIN; NORADRENALIN; OMEGA AGATOXIN VIA; OMEGA CONOTOXIN GVIA; OMEGA CONOTOXIN MVIIC; POTASSIUM CHANNEL; PROPRANOLOL; TETRODOTOXIN; TETRYLAMMONIUM;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DRUG EFFECT; ELECTRIC POTENTIAL; MALE; NEGATIVE FEEDBACK; NERVE ENDING; NONHUMAN; NORADRENALIN RELEASE; SYMPATHETIC NERVE; SYNAPTIC TRANSMISSION; VASCULAR RING; VEIN DILATATION;

ADRENERGIC FIBERS; ANIMALS; CALCIUM CHANNELS, Q-TYPE; DOSE-RESPONSE RELATIONSHIP, DRUG; FACE; FEEDBACK, BIOCHEMICAL; MALE; OMEGA-CONOTOXIN GVIA; PEPTIDES; POTASSIUM CHANNELS; RABBITS; TETRAETHYLAMMONIUM; VASODILATION; VEINS;

EID: 0037275060     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-002-0653-8     Document Type: Article

References (27)

1. Clasbrummel B, Osswald H, Illes P (1989) Inhibition of noradrenaline release by ω-conotoxin GVIA in the rat tail artery. Br J Pharmacol 96:101-110
2. 2+ channels in neurotransmission in the rat urinary bladder. Br J Pharmacol 116:1595-1598
3. 2+ channels in evoked release of norepinephrine from sympathetic neurons. Science 239:57-61
4. Ca channels in airway smooth muscle by cAMP-dependent and -independent mechanisms. J Clin Invest 93:371-379
5. Lundy PM, Frew R (1994) Effect of ω-agatoxin-IVA on autonomic neurotransmission. Eur J Pharmacol 261:79-84
6. McCleskey EW, Fox AP, Feldman DH, Cruz LJ, Olivera BM, Tsien RW, Yoshikami D (1987) ω-Conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle. Proc Natl Acad Sci USA 84:4327-4331
7. + channel resistant to charybdotoxin and iberiotoxin. Proc Natl Acad Sci USA 97:5562-5567
8. + conductance in acutely isolated pyramidal-like neurons from the rat basolateral amygdaloid complex. J Neurophysiol 78:1256-1262
9. Mellander S, Andersson PO, Afzelius LE, Hellstrand P (1982) Neural beta adrenergic dilatation of the facial vein in man. Possible mechanism in emotional blushing. Acta Physiol Scand 114:393-399
10. Nelson MT, Quayle JM (1995) Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol 268:C799-C822
11. Pegram BL, Bevan RD, Bevan JA (1976) Facial vein of the rabbit: Neurogenic vasodilation mediated by β-adrenergic receptors. Circ Res 39:854-860
12. Pruneau D, Angus JA (1990) ω-Conotoxin GVIA is a potent inhibitor of sympathetic neurogenic responses in rat small mesenteric arteries. Br J Pharmacol 100:180-184
13. Ren L-M, Nakane T, Chiba S (1994) Differential effects of ω-conotoxin GVIA and tetrodotoxin on vasoconstrictions evoked by electrical stimulation and nicotinic receptor stimulation in canine isolated, perfused splenic arteries. Br J Pharmacol 111:1321-1327
14. sα independent of phosphorylation by protein kinase A. Am J Physiol 265:H1460-H1465
15. Smith SJ, Augustine GJ (1988) Calcium ions, active zones and synaptic transmitter release. Trends Neurosci 11:458-464
16. + channels. Eur Respir J 11:571-574
17. 2+ plus tetraethylammonium medium: its usefulness in studying the effect of Ca antagonist on adrenergic neurotransmission. Jpn J Pharmacol 56:535-538
18. Tanaka Y, Mochizuki Y, Tanaka H, Shigenobu K (1999) Significant role of neuronal non-N-type calcium channels in the sympathetic neurogenic contraction of rat mesenteric artery. Br J Pharmacol 128:1602-1608
19. Tanaka Y, Someya S, Tanaka H, Tsuru H, Shigenobu K (2000) Potentiation of stretch-induced tone in the rabbit facial vein by an isoquinoline derivative LOE 908. Naunyn-Schmiedeberg's Arch Pharmacol 362:577-580
20. Tsuru H, Nakai S, Uchiyama T, Teranishi Y (1998) Endothelium-independent relaxant effect of 5-hydroxytryptamine (5-HT) on the isolated rabbit facial vein. J Smooth Muscle Res 34:101-110
21. Ca channel cloned from myometrium. Receptors Channels 3:185-199
22. 2+ channels in supporting hippocampal synaptic transmission. Science 264:107-111
23. Winquist RJ, Bevan JA (1980) Temperature sensitivity of tone in the rabbit facial vein: myogenic mechanism for cranial thermoregulation. Science 207:1001-1002
24. Wright CE, Angus JA (1996) Effects of N-, P- and Q-type neuronal calcium channel antagonists on mammalian peripheral neurotransmission. Br J Pharmacol 119:49-56
25. Yazejian B, DiGregorio DA, Vergara JL, Poage RE, Meriney SD, Grinnell AD (1997) Direct measurements of presynaptic calcium and calcium-activated potassium currents regulating neurotransmitter release at cultured Xenopus nerve-muscle synapses. J Neurosci 17:2990-3001
26. Zygmunt PM, Högestätt ED (1993) Calcium channels at the adrenergic neuroeffector junction in the rabbit ear artery. Naunyn-Schmiedeberg's Arch Pharmacol 347:617-623
27. Zygmunt PKE, Högestätt ED, Andersson K-E (1996) Effects of potassium channel inhibitors on nitrergic and adrenergic neurotransmission in lamina propria of the female rabbit urethra. Naunyn-Schmiedeberg's Arch Pharmacol 354:336-342