Potential preventive effects of follistatin-related protein/TSC-36 on joint destruction and antagonistic modulation of its autoantibodies in rheumatoid arthritis

International Immunology

Volumn 15, Issue 1, 2003, Pages 71-77

  Tanaka, Masao ^a   Ozaki, Shoichi ^b   Kawabata, Daisuke ^a   Kishimura, Masaaki ^c   Osakada, Fumio ^c   Okubo, Mitsuo ^d   Murakami, Masao ^a   Nakao, Kazuwa ^a   Mimori, Tsuneyo ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KANEKA CORPORATION   (Japan)

^d SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Autoantigens; Autoimmunity; C fos; Epitopes

Indexed keywords

AUTOANTIBODY; FOLLISTATIN; INTERSTITIAL COLLAGENASE; PROSTAGLANDIN E2; PROTEIN C FOS; STROMELYSIN; TRANSFORMING GROWTH FACTOR BETA;

AMINO ACID SEQUENCE; ANIMAL CELL; AUTOCRINE EFFECT; AUTOIMMUNITY; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE COURSE; DOWN REGULATION; ENZYME SYNTHESIS; EPSTEIN BARR VIRUS; ESCHERICHIA COLI; GENE EXPRESSION; GENE MAPPING; GENE SEQUENCE; HUMAN; HUMAN CELL; IMMUNOMODULATION; JOINT DESTRUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TARGETING; REVIEW; RHEUMATOID ARTHRITIS; SEQUENCE HOMOLOGY; SYNOVIOCYTE;

ANIMALS; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNITY; DISEASE MODELS, ANIMAL; EPITOPES; FOLLISTATIN-RELATED PROTEINS; MICE;

EID: 0037259834     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxg005     Document Type: Review

References (52)

1. Shibanuma, M., Mashimo, J., Mita, A., Kuroki, T. and Nose, K. 1993. Cloning from a mouse osteoblastic cell line of a set of transforming-growth-factor-beta 1-regulated genes, one of which seems to encode a follistatin-related polypeptide. Eur. J. Biochem. 217:13.
2. Zwijsen, A., Blockx, H., Van Arnhem, W., Willems, J., Fransen, L., Devos, K., Raymackers, J., Van de Voorde, A. and Slegers, H. 1994. Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue. Eur. J. Biochem. 225:937.
3. Patel, K., Connolly, D. J., Amthor, H., Nose, K. and Cooke, J. 1996. Cloning and early dorsal axial expression of Flik, a chick follistatin-related gene: evidence for involvement in dorsalization/neural induction. Dev. Biol. 178:327.
4. Hayette, S., Gadoux, M., Martel, S., Bertrand, S., Tigaud, I., Magaud, J. P. and Rimokh, R. 1998. FLRG (follistatin-related gene), a new target of chromosomal rearrangement in malignant blood disorders. Oncogene 16:2949.
5. Schneyer, A., Tortoriello, D., Sidis, Y., Keutmann, H., Matsuzaki, T. and Holmes, W. 2001. Follistatin-related protein (FSRP): a new member of the follistatin gene family. Mol. Cell. Endocrinol. 180:33.
6. Tsuchida, K., Arai, K. Y., Kuramoto, Y., Yamakawa, N., Hasegawa, Y. and Sugino, H. 2000. Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-beta family. J. Biol. Chem. 275:40788.
7. Sumitomo, K., Kurisaki, A., Yamakawa, N., Tsuchida, K., Shimizu, E., Sone, S. and Sugino, H. 2000. Expression of a TGF-beta 1 inducible gene, TSC-36, causes growth inhibition in human lung cancer cell lines. Cancer Lett. 155:37.
8. Towers, P., Patel, K., Withington, S., Isaac, A. and Cooke, J. 1999. Flik, a chick follistatin-related gene, functions in gastrular dorsalisation/neural induction and in subsequent maintenance of midline Sonic hedgehog signalling. Dev. Biol. 214:298.
9. Tanaka, M., Ozaki, S., Osakada, F., Mori, K., Okubo, M. and Nakao, K. 1998. Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases. Int. Immunol. 10:1305.
10. Lafyatis, R., Remmers, E. F., Roberts, A. B., Yocum, D. E., Sporn, M. B. and Wilder, R. L. 1989. Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids. J. Clin. Invest. 83:1267.
11. Wilder, R. L., Lafyatis, R., Roberts, A. B., Case, J., Kumkumian, G. K., Sano, H., Sporn, M. B. and Remmers, E. F. 1990. Transforming growth factor-β in rheumatoid arthritis. Ann. NY Acad. Sci. 593:197.
12. Wright, J. K., Cawston, T. E. and Hazleman, B. L. 1991. Transforming growth factor beta stimulates the production of the tissue inhibitor of metalloproteinases (TIMP) by human synovial and skin fibroblasts. Biochim, Biophys. Acta 1094:207.
13. Song, X. Y., Gu, M., Jin, W. W., Klinman, D. M. and Wahl, S. M. 1998. Plasmid DNA encoding transforming growth factor-beta 1 suppresses chronic disease in a streptococcal cell wall-induced arthritis model. J. Clin. Invest. 101:2615.
14. Chen, W., Jin, W., Cook, M., Weiner, H. L. and Wahl, S. M. 1998. Oral delivery of group A streptococcal cell walls augments circulating TGF-beta and suppresses streptococcal cell wall arthritis. J. Immunol. 161:6297.
15. Fava, R. A., Olsen, N. J., Postlethwaite, A. E., Broadley, K. N., Davidson, J. M., Nanney, L. B., Lucas, C. and Townes, A. S. 1991. Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia. J. Exp. Med. 173:1121.
16. Wahl, S. M., Allen, J. B., Costa, G. L., Wong, H. L. and Dasch, J. R. 1993. Reversal of acute and chronic synovial inflammation by anti-transforming growth factor beta. J. Exp. Med. 177:225.
17. Cheon, H., Yu, S. J., Yoo, D. H., Chae, I. J., Song, G. G. and Sohn, J. 2002. Increased expression of pro-inflammatory cytokines and metalloproteinase-1 by TGF-beta1 in synovial fibroblasts from rheumatoid arthritis and normal individuals. Clin. Exp. Immunol. 127:547.
18. Woolley, D. E., Glanville, R. W., Crossley, M. J. and Evanson, J. M. 1975. Purification of rheumatoid synovial collagenase and its action on soluble and insoluble collagen. Eur. J. Biochem. 54:611.
19. Werb, Z. and Alexander, C. M. 1997. Proteinases and matrix degradation. In Kelley, W. N., Harris, E. D., Ruddy, S. and Sledge, C. B., eds, Textbook of Rheumatology, p. 248. Saunders, Philadelphia, PA.
20. Edwards, D. R., Murphy, G., Reynolds, J. J., Whitham, S. E., Docherty, A. J., Angel, P. and Heath, J. K. 1987. Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J. 6:1899.
21. Raisz, L. G. 1990. Recent advances in bone cell biology: interactions of vitamin D with other local and systemic factors. Bone Miner. 9:191.
22. Shows, T. B., McAlpine, P. J., Boucheix, C., Collins, F. S., Conneally, P. M., Frezal, J., Gershowitz, H., Goodfellow, P. N. and Hall, J. G. 1987, Guidelines for human gene nomenclature. An international system for human gene nomenclature (ISGN, 1987). Cytogenet. Cell Genet. 46:11.
23. Shiozawa, S., Shimizu, K., Tanaka, K. and Hino, K. 1997. Studies on the contribution of c-fos/AP-1 to arthritic joint destruction. J. Clin. Invest. 99:1210.
24. Pati, U. K. 1992. Novel vectors for expression of cDNA encoding epitope-tagged proteins in mammalian cells. Gene 114:285.
25. Chubet, R. G. and Brizzard, B. L. 1996. Vectors for expression and secretion of FLAG epitope-tagged proteins in mammalian cells. Biotechniques 20:136.
26. Tanaka, M., Kishimura, M., Ozaki, S., Osakada, F., Hashimoto, H. Okubo, M., Murakami, M. and Nakao, K. 2000. Cloning of novel soluble gp 130 and detection of its neutralizing autoantibodies in rheumatoid arthritis. J. Clin. Invest. 106:137.
27. van Straaten, F., Muller, R., Curran, T., Van Beveren, C. and Verma, I. M. 1983. Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein. Proc. Natl Acad. Sci. USA. 80:3183.
28. Brusic, V., Rudy, G., Honeyman, G., Hammer, J. and Harrison, L. 1998. Prediction of MHC class II-binding peptides using an evolutionary algorithm and artificial neural network. Bioinformatics 14:121.
29. Honeyman, M. C., Brusic, V., Stone, N. L. and Harrison, L. C. 1998. Neural network-based prediction of candidate T cell epitopes. Nat. Biotechnol. 16:966.
30. Muller, R., Bravo, R., Burckhardt, J. and Curran, T. 1984. Induction of c-fos gene and protein by growth factors precedes activation of c-myc. Nature 312:716.
31. Ozaki, S. and Berzofsky, J. A. 1987. Antibody conjugates mimic specific B cell presentation of antigen: relationship between T and B cell specificity. J. Immunol. 138:4133.
32. Berzofsky, J. A. 1983. T-B reciprocity. An la-restricted epitope-specific circuit regulating T cell-B cell interaction and antibody specificity. Surv. Immunol. Res. 2:223.
33. Osthues, A., Knauper, V., Oberhoff, R., Reinke, H. and Tschesche, H. 1992. Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid. FEBS Lett. 296:16.
34. Sung, K., Mendelow, D., Georgescu, H. I. and Evans, C. H. 1988. Characterisation of chondrocyte activation in response to cytokines synthesised by a synovial cell line. Biochim. Biophys. Acta 971:148.
35. Watanabe, S., Georgescu, H. I., Mendelow, D. and Evans, C. H. 1986. Chondrocyte activation in response to factor(s) produced by a continuous line of lapine synovial fibroblasts. Exp. Cell Res. 167:218.
36. Lin, C. W., Robbins, P. D., Georgescu, H. I. and Evans, C. H. 1996. Effects of immortalization upon the induction of matrix metalloproteinases in rabbit synovial fibroblasts. Exp. Cell Res. 223:117.
37. Hesketh, R. 1994. FOS. In Hesketh, R., ed., The Oncogene Handbook, p. 178. Academic Press, London.
38. Hu, E., Mueller, E., Oliviero, S., Papaioannou, V. E., Johnson, R. and Spiegelman, B. M. 1994. Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes. EMBO J. 13:3094.
39. Ribbens, C., Andre, B., Jaspar, J. M., Kaye, O., Kaiser, M. J., De Groote, D. and Malaise, M. G. 2000. Matrix metalloproteinase-3 serum levels are correlated with disease activity and predict clinical response in rheumatoid arthritis. J. Rheumatol. 27:888.
40. Yamanaka, H., Matsuda, Y., Tanaka, M., Sendo, W., Nakajima, H., Taniguchi, A. and Kamatani, N. 2000. Serum matrix metalloproteinase 3 as a predictor of the degree of joint destruction during the six months after measurement, in patients with early rheumatoid arthritis. Arthritis Rheum. 43:852.
41. 2 production by human synovial cells and dermal fibroblasts. J. Exp. Med. 162:2163.
42. Mimori, T., Suganuma, K., Tanami, Y., Nojima, T., Matsumura, M., Fujii, T., Yoshizawa, T., Suzuki, K. and Akizuki, M. 1995. Autoantibodies to calpastatin (an endogenous inhibitor for calcium-dependent neutral protease, calpain) in systemic rheumatic diseases. Proc. Natl Acad. Sci. USA. 92:7267.
43. Despres, N., Talbot, G., Plouffe, B., Boire, G. and Menard, H. A. 1995. Detection and expression of a cDNA clone that encodes a polypeptide containing two inhibitory domains of human calpastatin and its recognition by rheumatoid arthritis sera. J. Clin. Invest. 95:1891.
44. Menard, H. A. and el-Amine, M. 1996. The calpain-calpastatin system in rheumatoid arthritis. Immunol. Today 17:545.
45. Suzuki, H., Kamimura, J., Ayabe, T. and Kashiwagi, H. 1990. Demonstration of neutralizing autoantibodies against IL-1 alpha in sera from patients with rheumatoid arthritis. J. Immunol. 145:2140.
46. Feldmann, M., Charles, P., Taylor, P. and Maini, R. N. 1998. Biological insights from clinical trials with anti-TNF therapy. Semin. Immunopathol. 20:211.
47. Wendling, D., Racadot, E. and Wijdenes, J. 1993. Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody. J. Rheumatol, 20:259.
48. Yoshizaki, K., Nishimoto, N., Mihara, M. and Kishimoto, T. 1998. Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody. Semin. Immunopathol. 20:247.
49. Oldstone, M. B. 1987. Molecular mimicry and autoimmune disease. Cell 50:819.
50. Albert, L. J. and Inman, R. D. 1999. Molecular mimicry and autoimmunity. N. Engl. J. Med. 341:2068.
51. Van Regenmortel, M. H. 1989. Structural and functional approaches to the study of protein antigenicity. Immunol. Today 10-266
52. Firestein, G. S. 1997. Etiology and pathogenesis of rheumatoid arthritis. In Kelley, W. N., Harris, E. D., Ruddy, S. and Sledge, C. B., eds, Textbook of Rheumatology, p. 851. Saunders, Philadelphia, PA.