The virotoxin model of HIV-1 enteropathy: Involvement of GPR15/Bob and galactosylceramide in the cytopathic effects induced by HIV-1 gp120 in the HT-29-D4 intestinal cell line

Journal of Biomedical Science

Volumn 10, Issue 1, 2003, Pages 156-166

  Maresca, Marc ^a   Mahfoud, Radhia ^a   Garmy, Nicolas ^a   Kotler, Donald P ^b   Fantini, Jacques ^a   Clayton, Frederic ^c  

^a AIX MARSEILLE UNIVERSITY   (France)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium signaling; Glycolipid; GPR15 Bob coreceptor; HIV 1 enteropathy; Intestinal cell line; Lipid raft; Protein kinase C; Virotoxin

Indexed keywords

GALACTOSYLCERAMIDE; GLYCOPROTEIN GP 120; NEUTRALIZING ANTIBODY;

ARTICLE; BIOLOGICAL MODEL; CELL LINE; CELL PROTECTION; CHRONIC DIARRHEA; COLON CARCINOMA; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DEPOLYMERIZATION; ENTEROPATHY; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALABSORPTION; MICROTUBULE ASSEMBLY; PRIORITY JOURNAL; PROTEIN BINDING; VIRUS PATHOGENESIS;

CELL LINE; CHLORIDES; CYTOSKELETON; ELECTROPHYSIOLOGY; GALACTOSYLCERAMIDES; HIV ENTEROPATHY; HIV ENVELOPE PROTEIN GP120; HUMANS; INTESTINAL MUCOSA; MEMBRANE MICRODOMAINS; MODELS, BIOLOGICAL; PEPTIDES, CYCLIC; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PEPTIDE; RECEPTORS, VIRUS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0037258717     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1159/000068089     Document Type: Article

References (44)

1. Adachi A, Koenig S, Gendelman HE, Daugherty D, Gattoni-Celli S, Fauci AS, Martin MA. Productive, persistent infection of human colorectal cell lines with human immunodeficiency virus. J Virol 61:209-213;1987.
2. Asmuth DM, Hammer SM, Wanke CA. Physiological effects of HIV infection on human intestinal epithelial cells: An in vitro model for HIV enteropathy. AIDS 8:205-211;1984.
3. Ball JM, Tian P, Zeng CQY, Morris AP, Estes MK. Age-dependent diarrhea induced by a rotaviral nonstructural glycoprotein. Science 272:101-104;1996.
4. Barnett SW, Barboza A, Wilcox CM, Forsmark CE, Levy JA. Characterization of human immunodeficiency virus type 1 strains recovered from the bowel of infected individuals. Virology 182:802-809;1991.
5. Clayton, F, Kapetanovic S, Kotler DP. Enteric microtubule depolymerization in HIV infection: A possible cause of HIV-associated enteropathy. AIDS 15:123-124;2001.
6. Clayton F, Kotler DP, Kuwada SK, Morgan T, Stepan C, Kuang J, Le J, Fantini J. Gp120-induced Bob/GPR15 activation. A possible cause of HIV enteropathy. Am J Pathol 159:1933-1939;2001.
7. Collman R, Balliet JW, Gregory SA, Friedman H, Kolson DL, Nathanson N, Srinivasan A. An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1. J Virol 66:7517-7521;1992.
8. Dayanithi G, Yahi N, Baghdiguian S, Fantini J. Intracellular calcium release induced by human immunodeficiency virus type 1 (HIV-1) surface envelope glycoprotein in human intestinal epithelial cells: A putative mechanism for HIV-1 enteropathy. Cell Calcium 18:9-18;1995.
9. Delézay O, Koch N, Yahi N, Hammache D, Tourres C, Tamalet C, Fantini J. Co-expression of CXCR4/fusin and galactosylceramide in the human intestinal epithelial cell line HT-29. AIDS 11:1311-1318;1997.
10. Delézay O, Yahi N, Tamalet C, Baghdiguian S, Boudier JA, Fantini J. Direct effect of type 1 human immunodeficiency virus (HIV-1) on intestinal epithelial cell differentiation: Relationship to HIV-1 enteropathy. Virology 238:231-242;1997.
11. Deng HK, Unutmaz D, KewalRamani VN, Littman DR. Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 388:296-300;1997.
12. Denker BM, Nigam SK. Molecular structure and assembly of the tight junction. Am J Physiol 274:F1-F9;1998.
13. Dwinell MB, Eckmann L, Leopard JD, Varki NM, Kagnoff MF. Chemokine receptor expression by human intestinal epithelial cells. Gastroenterology 117:359-367;1999.
14. Ehrenpreis ED, Ganger DR, Kochvar GT, Patterson BK, Craig RM. D-xylose malabsorption: Characteristic finding in patients with the AIDS wasting syndrome and chronic diarrhea. J Acquir Immune Defic Syndr 5:1047-1050;1992.
15. Fantini J, Yahi N, Chermann JC. Human immunodeficiency virus can infect the apical and basolateral surfaces of human colonic epithelial cells. Proc Natl Acad Sci USA 88:9297-9301;1991.
16. Fantini J, Yahi N, Baghdiguian S, Chermann JC. Human colon epithelial cells productively infected with human immunodeficiency virus show impaired differentiation and altered secretion. J Virol 66:580-585;1992.
17. Fantini J, Hammache D, Delezay O, Yahi N, Andre-Barres C, Rico-Lattes I, Lattes A. Synthetic soluble analogs of galactosylceramide (GalCer) bind to the V3 domain of HIV-1 gp120 and inhibit HIV-1-induced fusion and entry. J Biol Chem 272:7245-7252;1997.
18. Fantini J, Hammache D, Delezay O, Pieroni G, Tamalet C, Yahi N. Sulfatide inhibits HIV-1 entry into CD4-/CXCR4+ cells. Virology 246:211-220;1998.
19. Fantini J, Maresca M, Hammache D, Yahi N, Delezay O. Glycosphingolipid (GSL) microdomains as attachment platforms for host pathogens and their toxins on intestinal epithelial cells: Activation of signal transduction pathways and perturbations of intestinal absorption and secretion. Glycoconj J 17:173-179;2000.
20. Fox CH, Kotler D, Tierney A, Wilson CS, Fauci AS. Detection of HIV-1 RNA in the lamina propria of patients with AIDS and gastrointestinal disease. J Infect Dis 159:467-471;1989.
21. Gerhard R, Schmidt G, Hofmann F, Aktories K. Activation of Rho GTPases by Escherichia coli cytotoxic necrotizing factor 1 increases intestinal permeability in Caco-2 cells. Infect Immun 66:5125-5131;1998.
22. Gillin J S, Shike M, Alcock N, Urmacher S, Krown S, Kurtz RC, Lightdale CJ, Winawer SJ. Malabsorption and mucosal abnormalities of the small intestine in the acquired immunodeficiency syndrome. Ann Intern Med 102:619-624;1985.
23. Hammache D, Pieroni G, Yahi N, Delezay O, Koch N, Lafont H, Tamalet C, Fantini J. Specific interaction of HIV-1 and HIV-2 surface envelope glycoproteins with monolayers of galactosylceramide and ganglioside GM3. J Biol Chem 273:7967-7971;1998.
24. Hopkins AM, Li D, Mrsny RJ, Walsh SV, Nusrat A. Modulation of tight junction function by G protein-coupled events. Adv Drug Deliv Rev 41:329-340;2000.
25. Kotler DP, Gaetz HP, Lange M, Klein EB, Holt PR. Enteropathy associated with the acquired immunodeficiency syndrome. Ann Intern Med 101:421-428;1984.
26. Kotler DP, Shimada T, Snow G, Winson G, Chen W, Zhao M, Inada Y, Clayton F. Effect of combination antiretroviral therapy upon rectal mucosal HIV RNA burden and mononuclear cell apoptosis. AIDS 12:597-604;1998.
27. Kunzelmann K. The cystic fibrosis transmembrane conductance regulator and its function in epithelial transport. Rev Physiol Biochem Pharmacol 137:1-70;1999.
28. Meinild A, Klaerke DA, Loo DD, Wright EM, Zeuthen T. The human Na+-glucose cotransporter is a molecular water pump. J Physiol 508:15-21;1998.
29. Miller AR, Griffin GE, Batman P, Farquar C, Forster SM, Pinching AJ, Harris JR. Jejunal mucosal architecture and fat absorption in male homosexuals infected with human immunodeficiency virus. Q J Med 69:1009-1019;1988.
30. Montecucco C. How do tetanus and botulinum toxins bind to neuronal membranes? Trends Biochem Sci 11:314-317;1986.
31. Nelson JA, Wiley CA, Reynolds-Kohler C, Reese CE, Margaretten W, Levy JA. Human immunodeficiency virus detected in bowel epithelium from patients with gastrointestinal symptoms. Lancet i:259-262;1988.
32. Omary MB, Brenner DA, de Grandpre LY, Roebuck KA, Richman DD, Kagnoff MF. HIV-1 infection and expression in human colonic cells: Infection and expression in CD4+ and CD4- cell lines. AIDS 5:275-281;1991.
33. Popovic M, Sarngadharan MG, Read E, Gallo RC. Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science 224:497-500;1984.
34. Stockmann M, Fromm M, Schmitz H, Schmidt W, Riecken EO, Schulzke JD. Duodenal biopsies of HIV-infected patients with diarrhoea exhibit epithelial barrier defects but no active secretion. AIDS 12:43-51;1998.
35. Swaggerty CL, Frolov AA, McArthur MJ, Cox VW, Compans RW, Ball JM. The envelope glycoprotein from simian immunodeficiency virus contains an enterotoxin domain. Virology 277:250-261;2000.
36. Swaminathan S, Eswaramoorthy S. Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B. Nat Struct Biol 7:693-699;2000.
37. Trujillo JR, Goletiani NV, Bosch I, Kendrick C, Rogers RA, Trujillo EB, Essex M, Brain JD. T-tropic sequence of the V3 loop is critical for HIV-1 infection of CXCR4-positive colonic HT-29 epithelial cells. J Acquir Immune Defic Syndr 25:1-10;2000.
38. Turner JR, Angle JM, Black ED, Joyal JL, Sacks DB, Madara JL. PKC-dependent regulation of transepithelial resistance: Role of MLC and MLC kinase. Am J Physiol 277:C554-C562;1999.
39. Ullrich R, Zeitz M, Heise W, L'age M, Hoffken G, Riecken EO. Small intestinal structure and function in patients infected with human immunodeficiency virus (HIV). Evidence for HIV-induced enteropathy. Ann Intern Med 111:15-21;1989.
40. Ullrich R, Heise W, Bergs C, L'age M, Riecken EO, Zeitz M. Effect of zidovudine treatment on the small intestinal mucosa in patients infected with the human immunodeficiency virus. Gastroenterology 102:1483-1492;1992.
41. Veazey RS, Lackner A. The gastrointestinal tract and the pathogenesis of AIDS. AIDS 12:S35-S42;1998.
42. Waterman-Storer CM, Salmon E. Positive feedback interactions between microtubule and actin dynamics during cell motility. Curr Opin Cell Biol 11:61-67;1999.
43. Yahi N, Baghdiguian S, Moreau H, Fantini J. Galactosyl ceramide (or a closely related molecule) is the receptor for human immunodeficiency virus type 1 on human colon epithelial HT29 cells. J Virol 66:4848-4854;1992.
44. + human intestinal epithelial cells. Perspect Drug Discov Des 5:161-168;1996.