T-tropic sequence of the V3 loop is critical for HIV-1 infection of CXCR4-positive colonic HT-29 epithelial cells

Journal of Acquired Immune Deficiency Syndromes

Volumn 25, Issue 1, 2000, Pages 1-10

  Trujillo, J Roberto ^a   Goletiani, Nathalie V ^a   Bosch, Irene ^b   Kendrick, Colleen ^a   Rogers, Rick A ^a   Trujillo, Elaine B ^c   Essex, Max ^a   Brain, Joseph D ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Colonic cells; CXCR4; HIV 1 V3

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; GLYCOPROTEIN GP 120; NEUTRALIZING ANTIBODY;

ARTICLE; COLON MUCOSA; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOHISTOCHEMISTRY; INFECTION SENSITIVITY; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; VIRUS INFECTIVITY;

EID: 0034273712     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/00126334-200009010-00001     Document Type: Article

References (48)

1. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV
2. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
3. HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-couple receptor
4. CC CK5: A Rantes, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1
5. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
6. Identification of a major coreceptor for primary isolates of HIV-1
7. A dual-tropic HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3 and CKR-2b as fusion factors
8. + cells is mediated by a chemokine receptor CC-CKR-5
9. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia
10. HIV can productively infect cultured human glial cells
11. CD4-independent infection of human neural cells by human immunodeficiency virus type 1
12. CD-4 independent, productive infection of a Neural Cell Line by HIV-1
13. The human immunodeficiency virus can infect CD-negative human fibroblastoid cells
14. Soluble CD4 blocks the infectivity of diverse strains of HIV-1 and SIV for T cells and monocytes but not for brain and muscle cells
15. Human transformed trophoblast-derived cells lacking CD4 receptor exhibit restricted permissiveness for human immunodeficiency virus type 1
16. Isolation of normal human follicular dendritic cells and CD4-independent in vitro infection by human immunodeficiency virus (HIV- 1)
17. Galactosyl ceramide (or a closely related molecule) is the receptor for human immunodeficiency virus type 1 on human colon epithelial HT29 cells
18. Infection of cultured human adrenal cells by different strains of HIV-1
19. CD4 independent, productive human immunodeficiency virus type 1 infection of hepatoma cell lines in vitro
20. Galactosyl ceramide or a derivative is an essential component of the neural receptor for human immunodeficiency virus type I envelope glycoprotein gp120
21. Inhibition of entry of HIV-1 in neural cell lines by antibodies against galactosyl ceramide
22. Synthetic multimeric peptides derived from the principal neutralization domain (V3 loop) of human immunodeficiency virus type 1 gp120 bind to galactosylceramide and block HIV-1 infection in a human CD4-N negative mucosal epithelial cell line
23. The galcosyl/sulfatide receptor binding region of HIV-1 gp120 maps to amino acids 206-275
24. Binding of human immunodeficiency virus type 1 (HIV-1) gp120 to galactosylceramide (GalC): Relationship to the V3 loop
25. Human immunodeficiency iirus type 1 infection of SK-N-MC cells: Domains of gp120 involved in entry into a CD4-negative, galactosyl ceramide/ 3' sulfo-galactosyl ceramide-positive cell line
26. Identification of the envelope V3 loop as a determinant of a CD4-negative neuronal cell tropism for HIV-1
27. Phenotypic variations and switches in HIV-1 isolated from the blood and the gastrintestinal tissues of patients with HIV-1 infection
28. Characterization of human immunodeficiency virus type I strains recovered from the bowel of infected individuals
29. Intracellular calcium release induced by human immunodeficiency virus type 1 (HIV-1) surface envelope glycoprotein in human intestinal epithelial cells: A putative mechanism for HIV-1 enteropathy
30. Perturbations of glucose metabolism associated with HIV infection in human intestinal epithelial cells: A multinuclear magnetic resonance spectroscopy study
31. Co-expression of CXCR4/fusin and galactosylceramide in the human intestinal epithelial cell line HT-29
32. Complete nucleotide sequences of functional clones of the AIDS virus
33. The matrix protein of human immunodeficiency Virus type 1 is required for incorporation of viral envelope protein into mature virions
34. Nonrandom distribution of gp120 N-linked glycosylation sites important for infectivity of human immunodeficiency virus type 1
35. Infectivity assay (virus yield assay)
36. Human immunodeficiencey virus type 1 TAT protein activates B lymphocytes
37. Human immunodeficiency virus neutralizing antibodies recognize several conserved domains on the envelope glycoproteins
38. + T-cell lines determined by the capacity to exploit low concentrations of CCR5
39. T4 positive human neoplastic cell lines Susceptible to and permissive for HTLV-III
40. Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS
41. Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homology in comparison with T-cell-tropic isolates: Definition of critical amino acids involved in cell tropism
42. Human immunodeficiency virus type 1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity
43. Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncytium-inducing phenotype: Analysis by single amino acid Substitution
44. Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule
45. Evolution of the V3 envelope domain in proviral sequences and isolates of human immunodeficiency virus type 1 during transition of the viral biological phenotype
46. Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms
47. The common molecular virology of HIV-1 tropism in 'HIV-1 wasting syndrome' and 'AIDS dementia complex.'
48. Dementia in AIDS patients: Incidence and risk factors