Experimental infection of ponies with equine influenza A2 (H3N8) virus strains of different pathogenicity elicits varying interferon and interleukin-6 responses

Viral Immunology

Volumn 16, Issue 1, 2003, Pages 57-67

  Wattrang, Eva ^a,b   Jessett, David M ^b   Yates, Phillip ^b   Fuxler, Lisbeth ^a   Hannant, Duncan ^b  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b ANIMAL HEALTH TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; INTERLEUKIN 6;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HORSE; HORSE DISEASE; INFLUENZA VIRUS A; MALE; NONHUMAN; NOSE SECRETION; VIRUS INFECTION; VIRUS PATHOGENESIS; VIRUS STRAIN;

ANIMALIA; EQUIDAE; EQUUS CABALLUS; INFLUENZA VIRUS; INFLUENZAVIRUS A; RNA VIRUSES;

EID: 0037257485     PISSN: 08828245     EISSN: None     Source Type: Journal    
DOI: 10.1089/088282403763635456     Document Type: Article

References (53)

1. Aarden, L.A., E.R. De Groot, O.L. Schaap, et al. 1987. Production of hybridoma growth factor by human monocytes. Eur. J. Immunol. 17:1411-1416.
2. Akbar, A.N., J.M. Lord, and M. Salmon. 2000. IFN-alpha and IFN-beta: a link between immune memory and chronic inflammation. Immunol. Today 21:337-342.
3. Belardelli, F. 1995. Role of interferons and other cytokines in the regulation of the immune response. APMIS 103:161-179.
4. Belardelli, F., and I. Gresser. 1996. The neglected role of type I interferon in the T-cell response: implications for its clinical use. Immunol. Today 17:369-372.
5. Bogdan, C. 2000. The function of type I interferons in antimicrobial immunity. Curr. Opin. Immunol. 12:419-424.
6. Cardwell, J., R. Newton, J. Wood, et al. 2000. Equine influenza in donkeys in the New Forest. Vet. Rec. 147:400.
7. Chomik, M. 1981. Interferon induction by influenza virus: significance of neuraminidase. Arch. Immunol. Ther. Exp. 29:109-114.
8. Conn, C.A., J.L. McClellan, H.F. Maassab, et al. 1995. Cytokines and the acute phase response to influenza virus in mice. Am. J. Physiol. 268:R78-84.
9. De Maeyer, E. and J. De Maeyer-Guignard. 1998. Type I interferons. Int. Rev. Immunol. 17:53-73.
10. Dinarello, C.A. 1999. Cytokines as endogenous pyrogens. J. Infect. Dis. 179(Suppl 2):S294-304.
11. Fritz, R.S., F.G. Hayden, D.P. Calfee, et al. 1999. Nasal cytokine and chemokine responses in experimental influenza A virus infection: results of a placebo-controlled trial of intravenous zanamivir treatment. J. Infect. Dis. 180:586-593.
12. Garcia-Sastre, A. 2001. Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA viruses. Virology 279:375-384.
13. Gentile, D., W. Doyle, T. Whiteside, et al. 1998. Increased interleukin-6 levels in nasal lavage samples following experimental influenza A virus infection. Clin. Diagn. Lab. Immunol. 5:604-608.
14. Gentile, D.A., W.J. Doyle, P. Fireman, et al. 2001. Effect of experimental influenza A infection on systemic immune and inflammatory parameters in allergic and nonallergic adult subjects. Ann. Allergy. Asthma Immunol. 87:496-500.
15. Guo, Y., M. Wang, G.S. Zheng, et al. 1995. Seroepidemiological and molecular evidence for the presence of two H3N8 equine influenza viruses in China in 1993-94. J. Gen. Virol. 76:2009-2014.
16. Hannant, D., D.M. Jessett, T. O'Neill, et al. 1989. Antibody isotype responses in the serum and respiratory tract to primary and secondary infections with equine influenza virus (H3N8). Vet. Microbiol. 19:293-303.
17. Hannant, D. and J.A. Mumford. 1989. Cell mediated immune responses in ponies following infection with equine influenza virus (H3N8): the influence of induction culture conditions on the properties of cytotoxic effector cells. Vet. Immunol. Immunopathol. 21:327-337.
18. Hannant, D., and J.A. Mumford. 1996. Equine influenza. pp. 285-293. Ed. M.J. Studdert. Virus infections of equines. Elsevier: Amsterdam.
19. Hannant, D., J.A. Mumford, and D.M. Jessett. 1988. Duration of circulating antibody and immunity following infection with equine influenza virus. Vet. Rec. 122:125-128.
20. Hayden, F.G., R. Fritz, M.C. Lobo, et al. 1998. Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense. J. Clin. Invest. 101:643-649.
21. Hulten, C., B. Sandgren, E. Skioldebrand, et al. 1999. The acute phase protein serum amyloid A (SAA) as an inflammatory marker in equine influenza virus infection. Acta. Vet. Scand. 40:323-333.
22. Husband, A.J., S. Bao, and K.W. Beagley, 1999. Analysis of the mucosal microenvironment: factors determining successful responses to mucosal vaccines. Vet. Immunol. Immunopathol. 72:135-142.
23. Jensen-Waern, M., S.G. Persson, A. Nordengrahn, et al. 1998. Temporary suppression of cell-mediated immunity in standardbred horses with decreased athletic capacity. Acta. Vet. Scand. 39:25-33.
24. Julkunen, I., K. Melen, M. Nyqvist, et al. 2000. Inflammatory responses in influenza A virus infection. Vaccine 19(Suppl 1):S32-7.
25. Julkunen, I., T. Sareneva, J. Pirhonen, et al. 2001, Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression. Cytokine Growth Factor Rev. 12:171-180.
26. Kaiser, L., R.S. Fritz, S.E. Straus, et al. 2001. Symptom pathogenesis during acute influenza: interleukin-6 and other cytokine responses. J. Med. Virol. 64:262-268.
27. Kaufmann, A., R. Salentin, R.G. Meyer, et al. 2001. Defense against influenza A virus infection: essential role of the chemokine system. Immunobiology 204:603-613.
28. Kawaoka, Y., O.T. Gorman, T. Ito, et al. 1998. Influence of host species on the evolution of the nonstructural (NS) gene of influenza A viruses. Virus Res 55:143-156.
29. Le Bon, A., G. Schiavoni, G. D'Agostino, et al. 2001. Type 1 interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo. Immunity 14:461-470.
30. MacKay, R.J., A.M. Merritt, J.M. Zertuche, et al. 1991. Tumor necrosis factor activity in the circulation of horses given endotoxin. Am. J. Vet. Res. 52:533-538.
31. Majde, J.A., 2000. Viral double-stranded RNA, cytokines, and the flu. J. Interferon Cytokine Res. 20:259-272.
32. McGhee, J.R., K. Fujihashi, K.W. Beagley, et al. 1991. Role of interleukin-6 in human and mouse mucosal IgA plasma cell responses. Immunol. Res. 10:418-422.
33. Mogensen, T.H., and S.R. Paludan, 2001. Molecular pathways in virus-induced cytokine production. Microbiol. Mol. Biol. Rev. 65:131-150.
34. Morris, D.D., N. Crowe, J.N. Moore, et al. 1992. Endotoxin-induced production of interleukin 6 by equine peritoneal macrophages in vitro. Am. J. Vet. Res. 53:1298-1301.
35. Mumford, J., and J. Wood, 1993. WHO/OIE meeting: consultation on newly emerging strains of equine influenza. Vaccine 11:1172-1175.
36. Mumford, J., J.M. Wood, A.M. Scott, et al. 1983. Studies with inactivated equine influenza vaccine. 2. Protection against experimental infection with influenza virus A/equine/Newmarket/79 (H3N8). J. Hyg. (Lond) 90:385-395.
37. Mumford, J.A., 1999. The equine influenza surveillance program. Adv. Vet. Med. 41:379-387.
38. Mumford, J.A., D. Hannant, and D.M. Jessett, 1990. Experimental infection of ponies with equine influenza (H3N8) viruses by intranasal inoculation or exposure to aerosols. Equine Vet. J 22:93-98.
39. Oxburgh, L., L. Akerblom, T. Fridberger, et al. 1998. Identification of two antigenically and genetically distinct lineages of H3N8 equine influenza virus in Sweden. Epidemiol. Infect. 120:61-70.
40. Oxburgh, L., M. Berg, B. Klingeborn, et al. 1994. Evolution of H3N8 equine influenza virus from 1963 to 1991. Virus Res. 34:153-165.
41. Oxburgh, L., and B. Klingeborn, 1999. Cocirculation of two distinct lineages of equine influenza virus subtype H3N8. J. Clin. Microbiol. 37:3005-3009.
42. Pritts, T., E. Hungness, Q. Wang, et al. 2002. Mucosal and enterocyte IL-6 production during sepsis and endotoxemia - role of transcription factors and regulation by the stress response. Am. J. Surg. 183:372-383.
43. Romagnani, S., 1996. Understanding the role of Th1/Th2 cells in infection. Trends Microbiol. 4:470-473.
44. Skoner, D.P., D.A. Gentile, A. Patel, et al. 1999. Evidence for cytokine mediation of disease expression in adults experimentally infected with influenza A virus. J. Infect. Dis. 180:10-14.
45. Slater, J., and D. Hannant, 2000. Equine immunity to viruses. Vet. Clin. North Am. Equine. Pract. 16:49-68.
46. Stevceva, L., A.G. Abimiku, and G. Franchini, 2000. Targeting the mucosa: genetically engineered vaccines and mucosal immune responses. Genes Immunol. 1:308-315.
47. Talon, J., C.M. Horvath, R. Polley, et al. 2000. Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein. J. Virol. 74:7989-7996.
48. Van Reeth, K. 2000. Cytokines in the pathogenesis of influenza. Vet. Microbiol. 74:109-116.
49. Van Reeth, K., G. Labarque, S. De Clercq, et al. 2001. Efficacy of vaccination of pigs with different H1N1 swine influenza viruses using a recent challenge strain and different parameters of protection. Vaccine 19:4479-4486.
50. Van Reeth, K., G. Labarque, H. Nauwynck, et al. 1999. Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections: correlations with pathogenicity. Res. Vet. Sci. 67:47-52.
51. Van Reeth, K., H. Nauwynck, and M. Pensaert, 1998. Bronchoalveolar interferon-alpha, tumor necrosis factor-alpha, interleukin-1, and inflammation during acute influenza in pigs: a possible model for humans? J. Infect. Dis. 177:1076-1079.
52. Wang, X., M. Li, H. Zheng, et al. 2000. Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon. J. Virol. 74:11566-11173.
53. Wood, J.M., J. Mumford, C. Folkers, et al. 1983. Studies with inactivated equine influenza vaccine. 1. Serological responses of ponies to graded doses of vaccine. J. Hyg. (Lond) 90:371-384.