γ-Glutamyl transpeptidase activity alters the T cell response to oxidative stress and Fas-induced apoptosis

International Immunology

Volumn 15, Issue 1, 2003, Pages 17-27

  Carlisle, Margaret L ^a   King, Miranda R ^a   Karp, David R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Human; T lymhocyte; Transcription factor

Indexed keywords

CASPASE; CASPASE INHIBITOR; ENZYME VARIANT; FAS ANTIGEN; GAMMA GLUTAMYLTRANSFERASE; HYDROGEN PEROXIDE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; CELL CLONING; CELL KILLING; CELL NUCLEUS; CONTROLLED STUDY; DILUTION; ENZYME ACTIVITY; ENZYME ANALYSIS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INTRACELLULAR SPACE; LEUKEMIA CELL LINE; MEMORY CELL; MOLECULAR MODEL; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; SENSITIVITY ANALYSIS; T LYMPHOCYTE;

ANTIGENS, CD95; APOPTOSIS; CASPASES; CELL LINE, TRANSFORMED; ENZYME INHIBITORS; GAMMA-GLUTAMYLTRANSFERASE; GLUTATHIONE; HUMANS; LYMPHOCYTE ACTIVATION; NF-KAPPA B; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; T-LYMPHOCYTES;

EID: 0037256546     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxg010     Document Type: Review

References (65)

1. Fridovich, I. 1978. The biology of oxygen radicals. Science 201:875.
2. 2+ signals. J. Biol. Chem. 268:16688.
3. 2-induced T cell signal transduction. J. Biol. Chem. 269:20718.
4. Crabtree, G. R. and Clipstone, N. A. 1994. Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu. Rev. Biochem. 63:1045.
5. Staal, F. J., Anderson, M. T., Staal, G. E., Herzenberg, L. A. and Gitler, C. 1994. Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx. Proc. Natl Acad. Sci. USA 91:3619.
6. Gmunder, H. and Droge, W. 1991. Differential effects of glutathione depletion on T cell subsets. Cell. Immunol. 138:229.
7. Gmunder, H., Roth, S., Eck, H. P., Gallas, H., Mihm, S. and Droge, W. 1990. Interleukin-2 mRNA expression, lymphokine production and DNA synthesis in glutathione-depleted T cells. Cell. Immunol. 130:520.
8. Messina, J. P. and Lawrence, D. A. 1989. Cell cycle progression of glutathione-depleted human peripheral blood mononuclear cells is inhibited at S phase. J. Immunol. 143:1974.
9. Walsh, A. C., Michaud, S. G., Malossi, J. A. and Lawrence, D. A. 1995. Glutathione depletion in human T lymphocytes: analysis of activation-associated gene expression and the stress response. Toxicol. Appl. Pharmacol. 133:249.
10. Suthanthiran, M., Anderson, M. E., Sharma, V. K. and Meister, A. 1990. Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens. Proc. Natl Acad. Sci. USA 87:3343.
11. Steel, F. J., Roederer, M. and Herzenberg, L. A. 1990. Intracellular thiols regulate activation of nuclear factor κB and transcription of human immunodeficiency virus. Proc. Natl Acad. Sci. USA 87:9943.
12. Liang, S. M., Lee, N., Finbloom, D. S. and Liang, C. M. 1992. Regulation by glutathione of interleukin-4 activity on cytotoxic T cells. Immunology 75:435.
13. Hamilos, D. L., Mascali, J. J. and Wedner, H. J. 1991. The role of glutathione in lymphocyte activation-II. Effects of buthionine sulfoximine and 2-cyclohexene-1-one on early and late activation events. Int. J. Immunopharmacol. 13:75.
14. Noelle, R. J. and Lawrence, D. A. 1981. Determination of glutathione in lymphocytes and possible association of redox state and proliferative capacity of lymphocytes. Biochem. J. 198:571.
15. Schenk, H., Klein, M., Erdbrugger, W., Droge, W. and Schulze-Osthoff, K. 1994. Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-κB and AP-1. Proc. Natl Acad. Sci. USA 91:1672.
16. Schreck, R., Rieber, P. and Baeuerle, P. A. 1991. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO J. 10:2247.
17. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J. 12:2005.
18. Schulze-Osthoff, K., Los, M. and Baeuerle, P. A. 1995. Redox signalling by transcription factors NF-κB and AP-1 in lymphocytes. Biochem. Pharmacol. 50:735.
19. Mihm, S., Ennen, J., Pessara, U., Kurth, R. and Droge, W. 1991. Inhibition of HIV-1 replication and NF-κB activity by cysteine and cysteine derivatives. AIDS 5:497.
20. Baeuerle, P. A. and Baltimore, D. 1996. NF-κB: ten years after. Cell 87:13.
21. Gentz, R., Rauscher, F. J., III, Abate, C. and Curran, T. 1989. Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains. Science 243:1695.
22. Turner, R. and Tjian, R. 1989. Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers. Science 243:1689.
23. Schulze-Osthoff, K., Beyaert, R., Vandevoorde, V., Haegeman, G. and Fiers, W. 1993. Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF. EMBO J. 12:3095.
24. fyn tyrosine kinases in human lymphocytes. Blood 82:1212.
25. Devary, Y., Gottlieb, R. A., Smeal, T. and Karin, M. 1992. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell 71:1081.
26. Meister, A. 1992. On the antioxidant effects of ascorbic acid and glutathione. Biochem. Pharmacol. 44:1905.
27. Droge, W., Pottmeyer-Gerber, C., Schmidt, H. and Nick, S. 1986. Glutathione augments the activation of cytotoxic T lymphocytes in vivo. Immunobiology 172:151.
28. Liang, C. M., Lee, N., Cattell, D. and Liang, S. M. 1989. Glutathione regulates interleukin-2 activity on cytotoxic T-cells. J. Biol. Chem. 264:13519.
29. Griffith, O. W. 1980. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106:207.
30. Karp, D. R., Carlisle, M. L., Mobley, A. B., Nichols, T. C., Oppenheimer-Marks, N., Brezinschek, R. I. and Holers, V. M. 1999. γ-Glutamyl transpeptidase is up-regulated on memory T lymphocytes. Int Immunol. 11:1791.
31. Coligan, J. E., Kruisbeek, A. M., Margulies, D. H., Shevach, E. M. and Stober, W. 2002. Qualitative assessment of internucleosomal DNA fragmentation by agarose gel electrophoresis. In Coico, R., ed., Current Protocols in Immunology. Wiley, New York.
32. Ballard, D. W., Walker, W. H., Doerre, S., Sista, P., Molitor, J. A., Dixon, E. P., Peffer, N. J., Hannink, M. and Greene, W. C. 1990. The v-rel oncogene encodes a κB enhancer binding protein that inhibits NF-κB function. Cell 63:803.
33. Meister, A. 1995. Glutathione metabolism. Methods Enzymol. 251:3.
34. Lu, S. C. 2000. Regulation of glutathione synthesis. In Horecker, B. L., ed., Current Topics in Cell Regulation. Academic Press, New York.
35. Karp, D. R., Shimooku, K. and Lipsky, P. E. 2001. Expression of γ-glutamyl transpeptidase protects Ramos B cells from oxidation-induced cell death. J. Biol. Chem. 276:3798.
36. Jacobson, M. D. 1996. Reactive oxygen species and programmed cell death. Trends Biochem. Sci. 21:83.
37. Slater, A. F., Stefan, C., Nobel, I., van den Dobbelsteen, D. J. and Orrenius, S. 1995. Signalling mechanisms and oxidative stress in apoptosis. Toxicol. Lett. 82-83:149.
38. Chiba, T., Takahashi, S., Sato, N., Ishii, S. and Kikuchi, K. 1996. Fas-mediated apoptosis is modulated by intracellular glutathione in human T cells. Eur. J. Immunol. 26:1164.
39. Kohno, T., Yamada, Y., Hata, T., Mori, H., Yamamura, M., Tomonaga, M., Urata, Y., Goto, S. and Kondo, T. 1996. Relation of oxidative stress and glutathione synthesis to CD95(Fas/APO-1)-mediated apoptosis of adult T cell leukemia cells. J. Immunol. 156:4722.
40. van den Dobbelsteen, D. J., Nobel, C. S. I., Schlegel, J., Cotgreave, I. A., Orrenius, S. and Slater, A. F. 1996. Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody. J. Biol. Chem. 271:15420.
41. Um, H. D., Orenstein, J. M. and Wahl, S. M. 1996. Fas mediates apoptosis in human monocytes by a reactive oxygen intermediate dependent pathway. J. Immunol. 156:3469.
42. Barkett, M. and Gilmore, T. D. 1999. Control of apoptosis by Rel/NF-κB transcription factors. Oncogene 18:6910.
43. Bacso, Z., Everson, R. B. and Eliason, J. F. 2000. The DNA of annexin V-binding apoptotic cells is highly fragmented. Cancer Res. 60:4623.
44. Schreck, R., Meier, B., Mannel, D. N., Droge, W. and Baeuerle, P.A. 1992. Dithiocarbamates as potent inhibitors of nuclear factor κB activation in intact cells. J. Exp. Med. 175:1181.
45. Rothe, M., Pan, M. G., Henzel, W. J., Ayres, T. M. and Goeddel, D.V. 1995. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 83:1243.
46. Liston, P., Roy, N., Tamai, K., Lefebvre, C., Baird, S., Cherton-Horvat, G., Farahani, R., McLean, M., Ikeda, J. E., MacKenzie, A. and Korneluk, R. G. 1996. Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes. Nature 379:349.
47. Duckett, C. S., Nava, V. E., Gedrich, R. W., Clem, , R. J., Van Dongen, J. L., Gilfillan, M. C., Shiels, H., Hardwick, J. M. and Thompson, C. B. 1996. A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. EMBO J. 15:2685.
48. Deveraux, Q. L., Takahashi, R., Salvesen, G. S. and Reed, J. C, 1997. X-linked IAP is a direct inhibitor of cell-death proteases. Nature 388:300.
49. Roy, N., Deveraux, Q. L., Takahashi, R., Salvesen, G. S. and Reed, J. C. 1997. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. EMBO J. 16:6914.
50. +) cells. Cell. Immunol. 173:282.
51. Sarafian, T. A. and Bredesen, D. E. 1994. Is apoptosis mediated by reactive oxygen species? Free Radic. Res. 21:1.
52. Buttke, T. M. and Sandstrom, P. A. 1994. Oxidative stress as a mediator of apoptosis. Immunol. Today 15:7.
53. Gmunder, H., Eck, H. P. and Droge, W. 1991. Low membrane transport activity for cystine in resting and mitogenically stimulated human lymphocyte preparations and human T cell clones. Eur. J. Biochem. 201:113.
54. Ishii, T., Sugita, Y. and Bannai, S. 1987. Regulation of glutathione levels in mouse spleen lymphocytes by transport of cysteine. J. Cell Physiol. 133:330.
55. Toledano, M. B. and Leonard, W. J. 1991. Modulation of transcription factor NF-κB binding activity by oxidation-reduction in vitro. Proc. Natl Acad. Sci. USA 88:4328.
56. Kumar, S., Rabson, A. B. and Gelinas, C. 1992. The RxxRxRxxC motif conserved in all Rel/κB proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein. Mol. Cell. Biol. 12:3094.
57. Schoonbroodt, S., Legrand-Poels, S., Best-Belpomme, M. and Piette, J. 1997. Activation of the NF-κB transcription factor in a T-lymphocytic cell line by hypochlorous acid. Biochem, J. 321:777.
58. Bonizzi, G., Dejardin, E., Piret, B., Piette, J., Merville, M. P. and Bours, V. 1996. Interleukin-1 beta induces nuclear factor kappa B in epithelial cells independently of the production of reactive oxygen intermediates. Eur. J. Biochem. 242:544.
59. Devary, Y., Rosette, C., DiDonato, J. A. and Karin, M. 1993. NF-κB activation by ultraviolet light not dependent on a nuclear signal. Science 261:1442.
60. Kyriakis, J. M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F, Avruch, J. and Woodgett, J. R. 1994. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369:156.
61. fyn tyrosine kinases in human lymphocytes. Blood 82:1212.
62. Bauskin, A. R., Alkalay, I. and Ben-Neriah, Y. 1991. Redox regulation of a protein tyrosine kinase in the endoplasmic reticulum. Cell 66:685.
63. lck in T cells. Oncogene 8:3133.
64. + cells. J. Leukoc. Biol. 63:775.
65. Costello, R., Lipcey, C., Algarte, M., Cerdan, C., Baeuerle, P. A., Olive, D. and Imbert, J. 1993. Activation of primary human T-lymphocytes through CD2 plus CD28 adhesion molecules induces long-term nuclear expression of NF-κB. Cell Growth Differ. 4:329.