Endothelin receptor antagonist bosentan improves microcirculatory blood flow in splanchnic organs in septic shock

Critical Care Medicine

Volumn 31, Issue 1, 2003, Pages 203-210

  Krejci, Vladimir ^a   Hiltebrand, Luzius B ^a   Erni, Dominique ^a   Sigurdsson, Gisli H ^b  

^a UNIVERSITY OF BERN   (Switzerland)

^b LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

Author keywords

Bosentan; Endothelin; Intestine; Kidney; Liver; Microcirculation; Mucosa; Muscularis; Pancreas; Pigs; Sepsis; Septic shock

Indexed keywords

BOSENTAN; ENDOTHELIN RECEPTOR ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLON MUCOSA; CONTROLLED STUDY; DRUG EFFECT; HEART INDEX; JEJUNUM MUCOSA; KIDNEY; LASER DOPPLER FLOWMETRY; LIVER; MEAN ARTERIAL PRESSURE; MEASUREMENT; MICROCIRCULATION; NONHUMAN; PANCREAS; PERITONITIS; PRIORITY JOURNAL; SEPTIC SHOCK; SKELETAL MUSCLE; SPLANCHNIC BLOOD FLOW; STOMACH MUCOSA; STOMACH PH; SWINE;

ACID-BASE EQUILIBRIUM; ANALYSIS OF VARIANCE; ANIMALS; ANTIHYPERTENSIVE AGENTS; ENDOTHELINS; GASTRIC MUCOSA; HEMODYNAMIC PROCESSES; MICROCIRCULATION; SHOCK, SEPTIC; SPLANCHNIC CIRCULATION; STATISTICS, NONPARAMETRIC; SULFONAMIDES; SWINE;

EID: 0037253077     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200301000-00031     Document Type: Article

References (43)

1. Sigurdsson G, Christenson J, el-Rakshy M, et al: Intestinal platelet trapping after traumatic and septic shock. An early sign of sepsis and multiorgan failure in critically ill patients? Crit Care Med 1992; 20:458-467
2. Ruokonen E, Takala J, Kari A, et al: Regional blood flow and oxygen transport in septic shock. Crit Care Med 1993; 21:1296-1303
3. Hinshaw L: Sepsis/septic shock: Participation of the microcirculation: An abbreviated review. Crit Care Med 1996; 24:1072-1078
4. Clozel M, Clozel J: Effects of endothelin on regional blood flows in squirrel monkeys. J Pharmacol Exp Ther 1989; 250:1125-1131
5. Weitzberg E: Circulatory responses to endothelin-1 and nitric oxide with special reference to endotoxin shock and nitric oxide inhalation. Acta Physiol Scand Suppl 1993; 611:1-72
6. Furchgott R, Zawadzki J: The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288:373-376
7. Hollenberg S, Piotrowski M, Parrillo J: Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to endothelin-1 in septic rats. Am J Physiol 1997; 272:R969-974
8. Yanagisawa M, Kurihara H, Kimura S, et al: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332:411-415
9. Weitzberg E, Hemsen A, Lundberg J, et al: ET-3 is extracted by and induces potent vasoconstriction in human splanchnic and renal vasculatures. J Appl Physiol 1995; 79:1255-1259
10. Lundberg J, Ahlborg G, Hemsen A, et al: Evidence for release of endothelin-1 in pigs and humans. J Cardiovasc Pharmacol 1991; 17:S350-S353
11. Miura S, Fukumura D, Kurose I, et al: Roles of ET-1 in endotoxin-induced microcirculatory disturbance in rat small intestine. Am J Physiol 1996; 271:G461-G469
12. Lopez-Belmonte J, Whittle BJ: Endothelin-1 induces neutrophil-independent vascular injury in the rat gastric microcirculation. Eur J Pharmacol 1995; 278:R7-R9
13. Oldner A, Wanecek M, Goiny M, et al: The endothelin receptor antagonist bosentan restores gut oxygen delivery and reverses intestinal mucosal acidosis in porcine endotoxin shock. Gut 1998; 42:696-702
14. Hiltebrand L, Krejci V, Banic A, et al: Dynamic study of the distribution of microcirculatory blood flow in multiple splanchnic organs in septic shock. Crit Care Med 2000; 28:3233-3241
15. Hannon JP, Bossone CA, Rodkey WG: Splenic red cell sequestration and blood volume measurements in conscious pigs. Am J Physiol 1985; 248:R293-R301
16. Groeneveld AB, Kolkman JJ: Splanchnic tonometry: A review of physiology, methodology, and clinical applications. J Crit Care 1994; 9:198-210
17. Almond NE, Wheatley AM: Measurement of hepatic perfusion in rats by laser Doppler flowmetry. Am J Physiol 1992; 262:G203-G209
18. Wheatley AM, Almond NE, Stuart ET, et al: Interpretation of the laser Doppler flow signal from the liver of the rat. Microvasc Res 1993; 45:290-301
19. Kuznetsova L, Tomasek N, Sigurdsson G, et al: Estimation of muscle blood flow and resistance by laser Doppler flowmetry during changes in vascular tone. Am J Physiol 1998; 274:H1248-H1254
20. Banic A, Krejci V, Erni D, et al: Effects of sodium nitroprusside and phenylephrine on blood flow in free musculocutaneous flaps during general anesthesia. Anesthesiology 1999; 90:147-155
21. Gattinoni L, Brazzi L, Pelosi P, et al: A trial of goal-oriented hemodynamic therapy in critically ill patients. SvO2 Collaborative Group. N Engl J Med 1995; 333:1025-1032
22. Alia I, Esteban A, Gordo F, et al: A randomized and controlled trial of the effect of treatment aimed at maximizing oxygen delivery in patients with severe sepsis or septic shock. Chest 1999; 115:453-461
23. Gerber DR: Mucosal blood flow: Acting globally but we should be thinking locally. Crit Care Med 2000; 28:3359-3360
24. Ljungdahl M, Rasmussen I, Haglund U: Intestinal blood flow and intramucosal pH in experimental peritonitis. Shock 1999; 11:44-50
25. Weber C, Schmitt R, Birnboeck H, et al: Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects. Clin Pharmacol Ther 1996; 60:124-137
26. Sigurdsson G: Prevention of sepsis and multiple organ failure in critically ill patients. Acta Anaesthesiol Scand 1995; 39(Suppl 105):23-30
27. VanderMeer TJ, Wang H, Fink MP: Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock. Crit Care Med 1995; 23:1217-1226
28. Krejci V, Hiltebrand L, Banic A, et al: Continuous measurements of microcirculatory blood flow in gastrointestinal organs during acute haemorrhage. Br J Anaesth 2000; 84:468-475
29. Connolly HV, Maginniss LA, Schumacker PT: Transit time heterogeneity in canine small intestine: Significance for oxygen transport. J Clin Invest 1997; 99:228-238
30. Hamilton-Davies C, Mythen M, Salmon J, et al: Comparison of commonly used clinical indicators of hypovolaemia with gastrointestinal tonometry. Intensive Care Med 1997; 23:276-281
31. Gutierrez G, Palizas F, Doglio G, et al: Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients. Lancet 1992; 339:195-199
32. Jakob S, Kosonen P, Ruokonen E, et al: The Haldane effect - An alternative explanation for increasing gastric mucosal PCO2 gradients? Br J Anaesth 1999; 83:740-746
33. Hersch M, Gnidec AA, Bersten AD, et al: Histologic and ultrastructural changes in nonpulmonary organs during early hyperdynamic sepsis. Surgery 1990; 107:397-410
34. Foitzik T, Hotz H, Hot B, et al: Endothelin-1 mediates the acohol-induced reduction of pancreatic capillary blood flow. J Gastrointest Surg 1998; 2:379-384
35. Foitzik T, Faulhaber J, Hotz H, et al: Endothelin receptor blockade improves fluid sequestration, pancreatic capillary blood flow, and survival in severe experimental pancreatitis. Ann Surg 1998; 228:670-675
36. Benigni A, Remuzzi G: Endothelin antagonists. Lancet 1999; 353:133-138
37. Endlich K, Hoffend J, Steinhausen M: Localization of endothelin ETA and ETB receptor-mediated constriction in the renal microcirculation of rats. J Physiol (Lond) 1996; 497:211-218
38. King VanVlack C, Mewburn J, Chapler C: Receptor-mediated vascular and metabolic actions of endothelin-1 in canine small intestine. Am J Physiol 1999; 276:G1131-G1136
39. Takase H, Moreau P, Luscher T: Endothelin receptor subtypes in small arteries. Studies with FR139317 and bosentan. Hypertension 1995; 25:739-743
40. Cirino M, Martin E, Yano M, et al: Cardiovascular and renal actions of the endothelin(B) receptor in pigs. J Cardiovasc Pharmacol 1997; 29:704-712
41. Piper R, Pitt-Hyde M, Li F, et al: Microcirculatory changes in rat skeletal muscle in sepsis. Am J Respir Crit Care Med 1996; 154:931-937
42. Neviere R, Mathieu D, Chagnon J, et al: Skeletal muscle microvascular blood flow and oxygen transport in patients with severe sepsis. Am J Respir Crit Care Med 1996; 153:191-195
43. Ince C, Sinaasappel M: Microcirculatory oxygenation and shunting in sepsis and shock. Crit Care Med 1999; 27:1369-1377