Transit time heterogeneity in canine small intestine: Significance for oxygen transport

Journal of Clinical Investigation

Volumn 99, Issue 2, 1997, Pages 228-238

  Connolly, Heidi V ^a   Maginniss, Leigh A ^b   Schumacker, Paul T ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b DEPAUL UNIVERSITY   (United States)

Author keywords

blood vessels; capillaries; ischemia; microcirculation; oxygen consumption

Indexed keywords

ERYTHROCYTE TC 99M;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD GAS ANALYSIS; BLOOD VOLUME; CAPILLARY FLOW; CONTROLLED STUDY; DOG; HEMODYNAMICS; HISTOLOGY; INTESTINE BLOOD FLOW; INTESTINE PERFUSION; MICROCIRCULATION; NONHUMAN; OXYGEN SUPPLY; OXYGEN TRANSPORT; PRIORITY JOURNAL; SMALL INTESTINE; VASOCONSTRICTION;

EID: 0031016738     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119151     Document Type: Article

References (37)

1. Cain, S.M. 1983. Peripheral oxygen uptake and delivery in health and disease. Clin. Chest. Med. 4:139-148.
2. Schumacker, P.T., and S.M. Cain. 1987. The concept of a critical oxygen delivery. Intensive. Care. Med. 13:223-229.
3. Granger, D.N., P.R. Kvietys, and M.A. Perry. 1982. Role of exchange vessels in the regulation of intestinal oxygenation. Am. J. Physiol. 242:G570-G574.
4. Granger, H.J., A.H. Goodman, and B.K. Cook. 1975. Metabolic models of microcirculatory regulation. Fed. Proc. 34:2025-2030.
5. Cain, S.M. 1987. Gas exchange in hypoxia, apnea, and hyperoxia. In Handbook of Physiology: The Respiratory System Vol. IV, Section 3. A.P. Fishman, editor. American Physiological Society, Bethesda, MD. 403-420.
6. 2 extraction in canine intestine. J. Appl. Physiol. 77:2291-2298.
7. 2 delivery. J. Appl. Physiol. 76:1454-1461.
8. Buckberg, G.D., J.C. Luck, D.B. Payne, J.I. Hoffman, J.P. Archie, and D.E. Fixler. 1971. Some sources of error in measuring regional blood flow with radioactive microspheres. J. Appl. Physiol. 31:598-604.
9. 99m red blood cells for the determination of red cell volume. Am. J. Roentgenol. Radium Ther. Nuci. Med. 118:861-864.
10. Weibel, E.R. 1979. Stereological Morphology. Academic Press Inc., Orlando, FL.
11. Humer, M.F., P.T. Phang, B.P. Friesen, M.F. Allard. C.M. Goddard, and K.R. Walley. 1996. Heterogeneity of gut capillary transit times and impaired gut oxygen extraction in endotoxemic pigs. J. Appl. Physiol. 81:895-904.
12. Thomas, L.J., Jr. 1972. Algorithms for selected blood acid-base and blood gas calculations. J. Appl. Physiol. 33:154-158.
13. Shepherd, A.P., and G.L. Riedel. 1985. Laser-Doppler blood flowmetry of intestinal mucosal hyperemia induced by glucose and bile. Am. J. Physiol. 248:G393-G397.
14. Hultén, L., J. Lindhagen, and O. Lundgren. 1977. Sympathetic nervous control of intramural blood flow in the feline and human intestines. Gastroenterology. 72:41-48.
15. Lundgren, O. 1991. Microcirculation of the gastrointestinal tract and pancreas. In Handbook of Physiology, Sec 2, Vol. 4, Part 2, The Microcirculation. E.M. Renkin and C.C. Michel, editors. American Physiological Society, Bethesda, MD.
16. Perry, M.A., and D. N. Granger. 1981. Permeability of intestinal capillaries to small molecules. Am. J. Physiol. 241:G24-G30.
17. 2 in endotoxemic dogs during shock and resuscitation. J. Appl. Physiol. 76:793-800.
18. 2 uptake during sympathetic stimulation and partial arterial occlusion. Am. J. Physiol. 236:H731-H735.
19. Lautt, W.W., and S.A. Graham. 1977. Effect of nerve stimulation on precapillary sphincters, oxygen extraction and hemodynamics in the intestines of cats. Circ. Res. 41:32-36.
20. McNeill, J.R., R.D. Stark, and C.V. Greenway. 1970. Intestinal vasoconstriction after hemorrhage: roles of vasopressin and angiotensin. Am. J. Physiol. 219:1442-1447.
21. Dodd, S.L., C.E. King, and S.M. Cain. 1987. Responses of innervated and denervated gut to whole-body hypoxia. J. Appl. Physiol. 62:651-657.
22. Hogg, J.C., B.A. Martin, S. Lee, and T. McLean. 1985. Regional differences in erythrocyte transit in normal lungs. J. Appl. Physiol. 59:1266-1271.
23. Rose, C.P., and C.A. Goresky. 1985. Limitations of tracer oxygen uptake in the canine coronary circulation. Circ. Res. 56:57-71.
24. Rose, C.P., and C.A. Goresky. 1976. Vasomotor control of capillary transit time heterogeneity in the canine coronary circulation. Circ. Res. 39:541-554.
25. King, R.B., J.B. Bassingthwaighte, J.R.S. Hales, and L.B. Rowell. 1985. Stability of heterogeneity of myocardial blood flow in normal awake baboons. Circ. Res. 57:285-295.
26. Ellsworth, M.L., A.S. Popel, and R.N. Pittman. 1988. Assessment and impact of heterogeneities of convective oxygen transport parameters in capillaries of striated muscle: experimental and theoretical. Microvasc. Res. 35:341-362.
27. Piiper, J., D.R. Pendergast, C. Marconi, M. Meyer, N. Heisler, and P. Ceretelli. 1985. Blood flow distribution in dog gastrocnemius muscle at rest and during stimulation. J. Appl. Physiol. 58:2068-2074.
28. Sparks, H.V., and D.E. Mohrman. 1977. Heterogeneity of flow as an explanation for the multi-exponential washout of inert gas from skeletal muscle. Microvasc. Res. 13:181-184.
29. Tyml, K. 1987. Red cell perfusion in skeletal muscle at rest and after mild and severe contractions. Am. J. Physiol. 252:H485-H493.
30. Honig, C.R., and C.L. Odoroff. 1981. Calculated dispersion of capillary transit times: significance for oxygen exchange. Am. J. Physiol. 240:H199-H208.
31. Bassingthwaighte, J.B., R.B. King, and S.A. Roger. 1989. Fractal nature of regional myocardial blood flow heterogeneity. Circ. Res. 65:578-590.
32. Marcus, M.L., R.E. Kerber, J.C. Erhardt, H.L. Falsetti, D.M. Davis, and F.M. Abboud. 1977. Spatial and temporal heterogeneity of left ventricular perfusion in awake dogs. Am. Heart J. 94:748-754.
33. Allard, M.F., C.T. Kamimura, D.R. English, S.L. Henning, and B.R. Wiggs. 1993. Regional myocardial capillary erythrocyte transit time in the normal resting heart. Circ. Res. 72:187-193.
34. Tyml, K., and K. Mikulash. 1988. Evidence for increased perfusion heterogeneity in skeletal muscle during reduced flow. Microvasc. Res. 35:316-324.
35. Rose, C.P., C.A. Goresky, P. Belanger, and M.J. Chen. 1980. Effect of vasodilation and flow rate on capillary permeability surface product and interstitial space size in the coronary circulation. A frequency domain technique for modeling multiple dilution data with Laguerre functions. Circ. Res. 47:312-328.
36. Cousineau, D.F., C.A. Goresky, C.P. Rose, A. Simard, and A.J. Schwab. 1995. Effects of flow, perfusion pressure, and oxygen consumption on cardiac capillary exchange. J. Appl. Physiol. 78:1350-1359.
37. Maxwell, L.C., A.P. Shepherd, and G.L. Riedel. 1982. Vasodilation or altered perfusion pressure moves 15-mm spheres trapped in the gut wall. Am. J. Physiol. 243:H123-H127.