Hairy-cell leukaemia as a model for drug development

Best Practice and Research: Clinical Haematology

Volumn 16, Issue 1, 2003, Pages 83-89

  Carson, Dennis A ^a   Leoni, Lorenzo M ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Apoptosis; Caspases; DNA repair; Mitochondria; Nucleotide metabolism

Indexed keywords

ALPHA INTERFERON; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 9; CLADRIBINE; DRUG METABOLITE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NUCLEOTIDE; ANTILEUKEMIC AGENT; CASPASE; CYTARABINE; DEOXYADENOSINE; DEOXYCYTIDINE; GEMCITABINE; PURINE NUCLEOSIDE;

APOPTOSIS; CANCER CELL; CELL GROWTH; CELL PROLIFERATION; DRUG DEVELOPMENT; DRUG EFFECT; HAIRY CELL LEUKEMIA; HUMAN; LYMPHATIC SYSTEM; LYMPHOCYTE; MICROENVIRONMENT; MONOCYTE; PRIORITY JOURNAL; REMISSION; REVIEW; ANTINEOPLASTIC ACTIVITY; CANCER GROWTH; CANCER MODEL; CANCER REGRESSION; DRUG ACCUMULATION; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; FEASIBILITY STUDY; LEUKEMIA CELL;

EID: 0037251022     PISSN: 15216926     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1521-6926(02)00090-7     Document Type: Review

References (12)

1. Venter JC, Adams MD, Myers EW & Li PW. The human genome. Science 2002; 291: 1304-1351.
2. Grodzicky T & Elkon TB. Apoptosis: a case where too much or too little can lead to autoimmunity. Mount Sinai Journal of Medicine 2002; 69: 208-219.
3. Kajan J & Croce CM. Molecular biology of lymphoid malignancies. Annals of Oncology 1991; 2(supplement): 9-21.
4. Hazelhurst LA & Dawson WS. Mechanisms associated with cell adhesion mediated drug resistance (CAM-DR) in haematopoietic malignancies. Cancer and Metastasis Review 2001; 20: 43-50.
5. Carrera CJ, Terai C, Lotz Metal. Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. A novel approach to immunosuppressive therapy. Journal of Clinical Investigation 1990; 86: 1480-1488.
6. So EY, Park HH & Lee CE. IFN-gamma and IFN-alpha posttranscriptionally down-regulate the IL-4 induced IL-4 receptor gene expression. Journal of Immunology 2000; 164: 5472-5479.
7. Carson DA & Carrera CJ. Immunodeficiency secondary to adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency. Seminars in Hematology 1990; 27: 260-269.
8. Carson DA, Seto S, Wasson DB & Carrera CJ. DNA strand breaks, NAD metabolism and programmed cell death. Experimental Cell Research 1986; 164: 273-281.
9. Carson DA, Seto S & Wasson DB. Lymphocyte dysfunction after DNA damage by toxic oxygen species. A model of immunodeficiency. Journal of Experimental Medicine 1986; 163: 746-751.
10. Genini D, Adachi S, Chao Q et al. Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. Blood 2000; 96: 3537-3543.
11. Genini D, Budihardjo L, Plunkett W et al. Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway. Journal of Biological Chemistry 2000; 275: 29-34.
12. Grutter MG. Caspases: key players in programmed cell death. Current Opinion in Structural Biology 2000; 10: 649-655.