Weekly high-dose folic acid supplementation is effective in lowering serum homocysteine concentrations in women

Annals of Nutrition and Metabolism

Volumn 47, Issue 2, 2003, Pages 55-59

  Adank, Charlotte ^a   Green, Timothy J ^a   Skeaff, C Murray ^a   Briars, Brooke ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Cardiovascular disease; Folic acid supplements, weekly; Homocysteine; Women

Indexed keywords

FOLIC ACID; HOMOCYSTEINE; PLACEBO;

ADULT; ARTICLE; BLOOD ANALYSIS; BLOOD LEVEL; BLOOD SAMPLING; CELL LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; ERYTHROCYTE; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INTERMETHOD COMPARISON; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SERUM;

ADOLESCENT; ADULT; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; ERYTHROCYTES; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; NEURAL TUBE DEFECTS; TREATMENT OUTCOME;

EID: 0037235637     PISSN: 02506807     EISSN: None     Source Type: Journal    
DOI: 10.1159/000069278     Document Type: Article

References (19)

1. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG: A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 1995;274:1049-1057.
2. Christen W, Ajani UA, Glynn RJ, Hennekens CH: Blood levels of homocysteine and increased risks of cardiovascular disease. Arch Intern Med 2000;160:422-434.
3. Homocysteine Lowering Trialist's Collaboration: Lowering blood homocysteine with folic acid-based supplements: Meta-analysis of randomised trials. BMJ 1998;316:894-898.
4. Schnyder G, Roffi M, Pin R, Flammer Y, Lange H, Eberli FR, et al: Decreased rate of coronary restenosis after lowering of plasma homocysteine levels. N Engl J Med 2001;345(22):1593-1600.
5. Berry RJ, Li Z, Erickson JD, Li S, Moore CA, Wang H, et al: Prevention of neural-tube defects with folic acid in China. China-US Collaborative Project for Neural Tube Defect Prevention. N Engl J Med 1999;341:1485-1490.
6. MRC Vitamin Study Research Group: Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study. Lancet 1991;338:131-137.
7. Czeizel AE, Dudas I: Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 1992;327:1832-1835.
8. Briars B, Skeaff C, Green T, Adank C: Once-a-week versus daily folic acid supplementation: Effect on red blood cell folate concentration in women of childbearing age. Ann Nutr Metab 2001;45:55.
9. O'Broin S, Kelleher B: Microbiological assay on microtitre plates of folate in serum and red cells. J Clin Pathol 1992;45:344-347.
10. New Zealand Institute of Crop and Food Research: Food Files. The New Zealand Food Composition Database. Palmerston North, New Zealand Institute of Crop and Food Research, 1993.
11. Brouwer IA, van Dusseldorp M, Thomas CM, et al: Low-dose folic acid supplementation decreases plasma homocysteine concentrations: A randomized trial. Am J Clin Nutr 1999;69:99-104.
12. Wald DS, Bishop L, Wald NJ, et al: Randomized trial of folic acid supplementation and serum homocysteine levels. Arch Intern Med 2001;161:695-700.
13. Dierkes J, Kroesen M, Pietrzik K: Folic acid and vitamin B6 supplementation and plasma homocysteine concentrations in healthy young women. Int J Vitam Nutr 1998;68:98-103.
14. Ward M, McNulty H, McPartlin J, Strain JJ, Weir DG, Scott JM: Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid. QJM 1997;90:519-524.
15. Venn BJ, Mann J, Williams SM, Riddell LJ, Chisholm A, Harper MJ, et al: Maximum benefit of additional folic acid on homocysteine reduction may accrue from low-dose fortification. Eur J Clin Nutr 2002;56:748-754.
16. Steegers-Theunissen RP, Boers GH, Trijbels FJ, Finkelstein JD, Blom HJ, Thomas CM, et al: Maternal hyperhomocysteinemia: A risk factor for neural-tube defects? Metabolism 1994;43:1475-1480.
17. Vollset SE, Refsum H, Igens LM, Emblem BM, Tverdal A, Gjessing HK, et al: Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: The Hordaland Homocysteine study. Am J Clin Nutr 2000;71:962-968.
18. Mills JL, McPartlin JM, Kirke PN, Lee YJ, Conley MR, Weir DG, et al: Homocysteine metabolism in pregnancies complicated by neural-tube defects. Lancet 1995;345:149-151.
19. Graham IM, Daly LE, Refsum HM, Robinson K, Brattstrom LE, Ueland PM, et al: Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. JAMA 1997;277:1775-1781.