Zn2+ inhibits nitric oxide formation in response to lipopolysaccharides: Implication in its anti-inflammatory activity

European Journal of Pharmacology

Volumn 341, Issue 2-3, 1998, Pages 265-272

  Abou Mohamed, Gamal ^a   Papapetropoulos, Andreas ^a   D Catravas, John ^a   Caldwell, Robert W ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Endotoxin; Inflammation; Lipopolysaccharide; Nitric oxide (NO); Nitric oxide (NO) synthase; Zn2+

Indexed keywords

BRADYKININ; CALCIMYCIN; CYCLIC GMP; CYCLOHEXIMIDE; DACTINOMYCIN; ENDOTOXIN; HISTAMINE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; ZINC SULFATE; ANTIINFLAMMATORY AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANYLATE CYCLASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, RAT; NOS3 PROTEIN, RAT; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; AORTA; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; INFLAMMATORY DISEASE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; SMOOTH MUSCLE FIBER; ZINC DEFICIENCY; ANIMAL; BIOSYNTHESIS; DRUG EFFECT; METABOLISM; SPRAGUE DAWLEY RAT; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; AORTA; CYCLIC GMP; GUANYLATE CYCLASE; LIPOPOLYSACCHARIDES; MALE; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, SPRAGUE-DAWLEY; ZINC;

EID: 0032509563     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01416-7     Document Type: Article

References (48)

1. Abou-Mohamed G., El-kashef H.A., Salem H.A., Elmazar M.M. Effect of zinc on the anti-inflammatory and the ulcerogenic activities of indometacin and diclofenac. Pharmacology. 50:1995;266-272.
2. Abou-Mohamed G., Papapetropoulos A., Ulrich D., Catravas J.D., Caldwell R.W. HP-228, a novel synthetic peptide inhibits induction of nitric oxide synthase in vivo but not in vitro. J. Pharmacol. Exp. Ther. 275:1995;584-591.
3. Beckman J.S., Beckman T.W., Chen J., Marshall P.A., Freeman B.A. Apparent hydroxyl radical production by peroxynitrite, implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA. 87:1990;1620-1624.
4. Bradford M. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-253.
5. Bredt D.S., Snyder S.H. Isolation of nitric oxide synthase, a calmodulin-requiring enzyme. Proc.Natl. Acad. Sci. USA. 87:1990;682-685.
6. Bredt D.S., Glatt C.E., Hwang P.M., Fotuhi M., Dawson T.M., Snyder S.H. Nitric oxide synthase protein and mRNA are directly localized in neurornal populations of the mammalian CNS together with NADPH diaphorase. Neuron. 7:1991;615-642.
7. Brewer G.J. Calmodulin, zinc, and calcium in cellular and membrane regulation. Am. J. Hematol. 8:1980;231-248.
8. Bublitz C. The use of dithiothreitol in the assay of phenylalanine hydroxylase. Biochem. Med. 17:1977;13-19.
9. Carrico R.J., Deutsch H.F. The presence of zinc in human cytocuprein and some properties of the apoprotein. J. Biol. Chem. 245:1970;723-727.
10. Carter P. Spectrophotometric submicrogram serum zinc assay, an application for the routine service laboratory. Clin. Chem. Acta. 52:1974;227-286.
11. Cho H.J., Xie Q., Calaycay J., Mumford R.A., Swiderek K.M., Lee T.D., Nathan C. Calmodulin is a subunit of nitric oxide synthase from macrophages. J. Exp. Med. 176:1992;599-604.
12. Di Rosa M., Willoughby D.A. Screens for anti-inflammatory drugs. J. Pharm. Pharmacol. 23:1971;297-298.
13. Di Rosa M., Giroud J.P., Willoughby D.A. Studies of mediators of the acute inflammatory response induced in rats in different sites by carrageenin and turpentine. J. Pathol. 104:1971;15-24.
14. Dinarello C.A. Interleukin-1. Rev. Infec. Dis. 6:1984;51W-95.
15. Dinarello C.A. Interleukin-1. Dig. Dis. Sci. 33:1988;25S-35S.
16. Ding A.H., Nathan C., Stuehr D.J. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J. Immunol. 141:1988;2407-2412.
17. DiSilvestro R.A., Cousins R.J. Mediation of endotoxin-induced changes in zinc metabolism in rats. Am. J. Physiol. 247:1984;E346-E441.
18. Donnelly T.E. Jr. Effects of zinc chloride on the hydrolysis of cyclic GMP and cyclic AMP by the activator-dependent cyclic nucleotide phosphodiesterase from bovine heart. Biochem. Biophys. Acta. 522:1978;151-160.
19. 2. Comp. Biochem. Phys. - C, Comp. Pharmacol. Toxicol. 102:1991;325-327.
20. Förstermann U., Schmidt H.H., Pollock J.S., Sheng H., Mitchell J.A., Warner T.D., Nakane M., Murad F. Isoforms of nitric oxide synthase, Characterization and purification from different cell types. Biochem. Pharmacol. 42:1991;1849-1857.
21. Greenstock C.l., Jinat C.P., Whitehouse R.P., Sargent M.D. DNA radiation damage and its modification by metallothionein. Free Rad. Res. Commun. 2:1987;233-239.
22. Hammermueller J.D., Bray T.M., Bettger W.J. Effect of zinc deficincy on NADPH and cytochrome P-450 dependent active oxygen generation in rat lung and liver. Fed. Proc. 45:1986;1083.
23. 2+. Biochem. J. 270:1990;351-356.
24. Hevel J.M., White K.A., Marletta M.A. Purification of the inducible murine macrophage nitric oxide synthase: Identification as a flavoprotein. J. Biol. Chem. 266:1991;22789-22791.
25. Hughes S.R., Williams T.J., Brain S.D. Evidence that endogenous nitric oxide modulates oedema formation induced by substance P. Eur. J. Pharmacol. 191:1990;481-484.
26. Ialenti A., Inanaro A., Moncada S., Dirosa M. Modulation of acute inflammation by endogenous nitric oxide. Eur. J. Pharmacol. 211:1992;177-182.
27. Karin M. Metallothioneins, Proteins in Search of Function. Cell. 41:1985;9-10.
28. Kaufman S. Studies on the mechanisms of enzymatic conversion of phenylalanine to tyrosine. J. Biol. Chem. 234:1959;2677-2682.
29. Kennedy A.C., Fell G.S., Roony P.G., Stenens W.H., Dick W.C., Buchanan W.W. Zinc, its relationship to osteoporosis in rheumatoid arthritis. Scand. J. Rheumatol. 4:1975;243-245.
30. Kolb H., Kolb-Bachofer V. Nitric oxide, a pathogenic factor in auto immunity. Immunol. Today. 13:1992;157-160.
31. Kubes P., Suzuki M., Granger D.N. Nitric oxide an endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci. USA. 88:1991;4651-4655.
32. Kwon N.S., Nathan C.F., Stuehr D.J. Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages. J. Biol. Chem. 264:1990;20496-20501.
33. Langrehr J.M., Murase N., Markus P.M., Cai X., Neuhaus P., Schraut W., Simmons R.L., Hofman R.A. Nitric oxide production in graft-versus-host reactions in the rat. J. Clin. Invest. 90:1992;679-683.
34. McCartney-Francis N., Allen J.B., Mizel D.E., Albina J.E., Xie Q., Nathan C., Wahl S.M. Suppression of arthritis by an inhibitor of nitric oxide synthase. J. Exp. Med. 178:1993;749-754.
35. Moncada S., Palmer R.M.J., Higgs E.A. Nitric oxide: Physiology, Pathophysiology and Pharmacology. Pharmacol. Rev. 43:1991;109-142.
36. Mulligan M.S., Heirel J.M., Marletta M.A., Ward P.A. Tissue injury caused by deposition of immune complexes is L-arginine dependent. Proc. Natl. Acad. Sci. USA. 88:1991;6338-8342.
37. Oliva J.C., Castell M., Queralt J., Castellote C. Effect of chronic inflammation on copper and zinc metabolism. Rev. Esp. Fisiol. 43:1987;25.
38. Papapetropoulos A., Marczin N., Snead M.D., Cheng C., Milici A., Catravas J.D. Smooth muscle cell responsiveness to nitrovasodilators in hypertensive and normotensive rats. Hypertension. 23:1994;476-484.
39. Salvemini D., Misko T.P., Masferrer J.L., Seibert K., Currie M.G., Needleman P. Nitric oxide activates cyclooxygenase enzymes. Proc. Natl. Acad. Sci. USA. 90:1993;7240-7244.
40. Salvemini D., Seibert K., Masferrer J.L., Misko T.P., Currie M.G., Needleman P. Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation. J. Clinic. Invest. 93:1994;1940-1947.
41. Sevensen K.L.G., Hallgnen R., Johnsson E., Lindh U. Reduced zinc in peripheral blood cells from patients with inflammatory connective tissue diseases. Inflammation. 9:1985;189-197.
42. Simkin P.A. Oral zinc sulphate in rheumatoid arthritis. Lancet. 21:1976;539-542.
43. Snyder S.H., Bredt D.S. Nitric oxide as a neuronal messenger. Trends Pharmacol. Sci. 12:1991;125-128.
44. Sobocinski P.Z., Canterbury W.J. Jr., Mapes C.A. Induction of hepatic zinc-binding proteins by endotoxin and leukocytic endogenous mediators LEM. Fed. Proc. 36:1977;1100.
45. Thornalley P.J., Vasak M. Possible role for metallothionein in protection against radiation-induced oxidative stress: Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals. Biochem. Biophys. Acta. 827:1985;36-44.
46. Vallee, B.L., 1983. Zinc in Biology and Biochemistry. In: Spiro, T.G. (Ed.), Zinc Enzymes. Wiley, Toronto, p. 4.
47. Warren J.B., Coughlan M.L., Williams T.J. Endotoxin-induced vasodilatation in anaesthetized rat skin involves nitric oxide and prostaglandin synthesis. Br. J. Pharmacol. 106:1992;953-957.
48. Yui Y., Hattori R., Kosuga K., Eizawa H., Hiki K., Ohkawa S., Ohnishi K., Terao S., Kawai C. Calmodulin-independent nitric oxide synthase from rat polymorphonuclear neutrophils. J. Biol. Chem. 266(6):1991;3369-3371.