Coexpression of inducible NO synthase and soluble guanylyl cyclase in colonic enterocytes: A pathophysiologic signaling pathway for the initiation of diarrhea by gram-negative bacteria?

FASEB Journal

Volumn 12, Issue 15, 1998, Pages 1643-1649

  Closs, Ellen I ^a   Enseleit, Frank ^a   Koesling, Doris ^b   Pfeilschifter, Josef M ^c   Schwarz, Petra M ^a   Förstermann, Ulrich ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

Aminoguanidine; Anti NO synthase antibodies; Dexamethasone; Lipopolysaccharide; NO synthase mRNA; Ribonuclease protection analysis

Indexed keywords

AMINOGUANIDINE; BACTERIUM LIPOPOLYSACCHARIDE; CYCLIC GMP; DEXAMETHASONE; ENDOTOXIN; EXOTOXIN; GUANYLATE CYCLASE; MESSENGER RNA; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON MUCOSA; CONTROLLED STUDY; DIARRHEA; ENZYME INDUCTION; GRAM NEGATIVE INFECTION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTESTINE CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RIBONUCLEASE PROTECTION ASSAY;

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0031788267     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.12.15.1643     Document Type: Article

References (34)

1. Levine, M. M. (1987) Escherichia coli that cause diarrhea: enterotoxigenic, enteropathogenic, enteroinvasive, enterohemorrhagic, and enteroadherent. J. Infect. Dis. 155, 377-389
2. Blanco, J., Blanco, M., Garabal, J. I., and Gonzalez, E. A. (1991) Enterotoxins, colonization factors and serotypes of enterotoxigenic Escheiichia coli from humans and animals. Microbiologia 7, 57-73
3. Wedel, B. J., and Garbers, D. L. (1997) New insights on the functions of the guanylyl cyclase receptors. FEBS Lett. 410, 29-33
4. Koesling, D., Böhme, E., and Schnltz, G. (1991) Guanylyl cyclases, a growing family of .signal-transducing enzymes. FASEB J. 5,2785-2791
5. Garbers, D. L., Koesling, D., and Schultz, G. (1994) Guanylyl cyclase receptors. Mol. Biol. Cell 5, 1-5
6. Jann, K., and Jann, B. (1987) Polysaccharide antigens of Escherichia coll. Rev. Infect. Dis. 9 (Suppl. 5), S517-S526
7. Rietschel, E. T., Kirikae, T., Schade, F. U., Mamat, U., Schmidt, G., Loppnow, H., Ulmer, A. J., Zahringer, U., Seydel, U., Di Padova, F., et al. (1994) Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J. 8, 217-225
8. Raetz, C. R., Ulevitch, R. J., Wright, S. D., Sibley, C. H., Ding, A., and Nathan, C. F. (1991 ) Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J. 5, 2652-2660
9. Schmidt, H. H. H. W., Lohmann, S. M., and Walter, U. (1993) The nitric oxide and cGMP signal transduction system: regulation and mechanism of action. Biochim. Biophys. Acta 1178, 153-175
10. Chomczynski, P., and Sacchi, N. (1987) Single-step method of RNA isolation by acid gtianidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159
11. Nakane, M., Saheki, S., Kuno, T., Ishii, K., and Murad, F. (1988) Molecular cloning of a cDNA coding for 70 kDa subunit of soluble guanylate cyclase from rat lung. Biochem. Biophys. Res. Commun. 157, 1139-1147
12. Kleinert, H., Euchenhofer, C., Ihrig-Biedert, I., and Förstermann, U. (1996) In murine 3T3 fibroblasts, different second messenger pathways resulting in the induction of NO synthase II (iNOS) converge in the activation of transcription factor NFκB. J. Biol. Chem. 271, 6039-6044
13. Schwarz, P. M., Gierten, B., Boissel, J.-P., and Förstermann, U. (1998) Expressional down-regulation of neuronal-type nitric oxide synthase I by glucocorticoids in N1E-115 neuroblastoma cells. Mol. Pharmacol. 54, in press
14. Schwarz, P. M., Rodriguez-Pascual, F., Koesling, D., Torres, M., and Förstermann, U. (1998) Functional coupling of nitric oxide synthase and soluble guanylyl cyclase in controlling catecholamine secretion from bovine chromaffin cells. Neuroscience 82, 255-265
15. Guthmann, F., Mayer, B., Koesling, D., Kukovetz, W. R., and Böhme, E. (1992) Characterization of soluble platelet guanylyl cyclase with peptide antibodies. Naunyn. Schmiedebergs Arch. Pharmacol. 346, 537-541
16. Nitsch, D. D., Ghilardi, N., Mühl, H., Nitsch, C., Brüne, B., and Pfeilschifter, J. (1997) Apoptosis and expression of inducible nitric oxide synthase are mutually exclusive in renal mesangial cells. Am. J. Pathol. 150, 889-900
17. Schmidt, H. H. H. W., Pollock, J. S., Nakane, M., Gorsky, L. D., Förstermann, U., and Murad, F. (1991) Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase. Proc. Natl. Acad. Sci. USA 88, 365-369
18. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227, 680-685
19. Radomski, M. W., Palmer, R. M., and Moncada, S. (1990) Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc. Natl. Acad. Sci. USA 87, 10043-10047
20. DiRosa, M., Radomski, M., Carnuccio, R., and Moncada, S. (1990) Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages. Biochem. Biophys. Res. Commun. 172, 1246-1252
21. Kleinert, H., Euchenhofer, C., Ihrig-Biedert, I., and Förstermann, U. (1996) Gliicocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-KB. Mol. Pharmacol. 49, 15-21
22. Misko, T. P., Moore, W. M., Kasten, T. P., Nickols, G. A., Corbett, J. A., Tilton, R. G., McDaniel, M. L., Williamson J. R., and Currie, M. G. (1993) Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur.J. Pharmacol. 233, 119-125
23. Griffiths, M. J. D., Messent, M., Macallister, R. J., and Evans, T. W. (1993) Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br. J. Pharmacol. 110, 963-968
24. Förstermann, U., and Kleinen, H. (1995) Nitric oxide synthase: expression and expressional control of the three isoforms. Naunyn. Schmiedeberg's Arch. Pharmacol. 352, 351-364
25. Sherman, P. A., Laubach, V. E., Reep, B. R., and Wood, E. R. (1993) Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line. Biochemistry 32, 11600-11605
26. Gath, I., Closs, E. I., Gödtel-Armbrust, U., Schmitt, S., Nakane, M., Wessler, I., and Förstermann, U. (1996) Inducible NO synthase II and neuronal NO synthase I are constitutively expressed in different structures of guinea pig skeletal muscle: implications for contractile function. FASEB J. 10, 1614-1620
27. Hoffman, R. A., Zhang, G. S., Nüssler, N. C., Gleixner, S. L., Ford, H. R., Simmons, R. L., and Watkins, S. G. (1997) Constitutive expression of inducible nitric oxide synthase in the mouse ileal mucosa. Am. J. Physiol. 272, G383-G392
28. Förstermann, U., Schmidt, H. H. H. W., Kohlhaas, K. L., and Murad, F. (1992) Induced RAW 264.7 macrophages express soluble and paniculate nitric oxide synthase: inhibition by transforming growth factor-beta. Eur.J. Pharmacol. Mol. Pharmacol. 225, 161-165
29. Gath, I., Götel-Armbrust, U., and Förstermann, U. (1997) Expressional downregulation of neuronal-type NO synthase I in guinea pig skeletal muscle in response to bacterial lipopolysaccharide. FEBS Lett. 410, 319-323
30. Mülsch, A., Busse, R., Liebau, S., and Förstermann, U. (1988) LY 83583 interferes with the release of endothelium-derived relaxing factor and inhibits soluble guanylate cyclase. J. Pharmacol. Exp. Ther. 247, 283-288
31. Mayer, B., Brunner, F., and Schmidt, K. (1993) Inhibition of nitric oxide synthesis by methylene blue. Biochem. Pharmacol. 45, 367-374 .
32. 1H-[l,2,4]oxadiazolo[4,3-a]quinoxalin- 1-one. Mol. Pharmacol. 48, 184-188
33. Rachmilewitz, D., Stamler, J. S., Bachwich, D., Karmeli, F., Ackerman, Z., and Podolsky, D. K. (1995) Enhanced colonie nitric oxide generation and nitric oxide synthase activity in ukerative colitis and Crohn's disease. Gut 36, 718-723
34. Ford, H., Watkins, S., Reblock, K., and Rowe, M. (1997) The role of inflammatory cytokines and nitric oxide in the pathogenesis of necrotizing enterocolitis. J. Pediatr. Surg. 32, 275-282