Saccharomicins, novel heptadecaglycoside antibiotics produced by Saccharothrix espanaensis: Antibacterial and mechanistic activities

Antimicrobial Agents and Chemotherapy

Volumn 44, Issue 8, 2000, Pages 2154-2159

  Singh, M P ^a   Petersen, P J ^a   Weiss, W J ^a   Kong, F ^a   Greenstein, M ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CALCIUM ION; GLYCOSIDE; MAGNESIUM ION; SACCHAROMICIN A; SACCHAROMICIN B; UNCLASSIFIED DRUG;

ACTINOBACTERIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACILLUS SUBTILIS; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; CYTOLYSIS; DRUG STRUCTURE; ENTEROCOCCUS; ESCHERICHIA COLI; EXPERIMENTAL INFECTION; HUMAN; HUMAN CELL; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SACCHAROTHRIX;

ACTINOMYCETALES; AMINOGLYCOSIDES; ANIMALS; ANTI-BACTERIAL AGENTS; CARBOHYDRATE SEQUENCE; CATIONS; CELL MEMBRANE; DISEASE MODELS, ANIMAL; DNA; DRUG INTERACTIONS; FEMALE; GRAM-POSITIVE BACTERIAL INFECTIONS; HEMOLYSIS; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PROTEIN BIOSYNTHESIS; PROTEINS; STAPHYLOCOCCUS; VANCOMYCIN;

EID: 0033931843     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.8.2154-2159.2000     Document Type: Article

References (14)

1. Chopra, I., J. Hodgson, B. Metcalf, and G. Poste. 1997. The search for antimicrobial agents effective against bacteria resistant to multiple antibiotics. Antimicrob. Agents Chemother. 41:497-503.
2. Demain, A. L. 1998. Microbial natural products; alive and well in 1998. Nat. Biotechnol. 16:3-4.
3. Hancock, R. E. W. 1997. The bacterial outer membrane as a drug barrier. Trends Microbiol. 5:37-42.
4. Jack, D. B. 1996. Drug-resistant bacteria: responding to infectious disease crisis. Mol. Med. Today 12:499-502.
5. Kirby, J. P., D. B. Borders, W. M. Maiese, R. T. Testa, and D. P. Labeda. September 1989. Antibiotic LL-C19004. U.S. patent 4,870,019.
6. Kong, F., N. Zhao, M. M. Siegel, K. Janota, J. S. Ashcroft, F. E. Koehn, D. B. Borders, and G. T. Carter. 1998. Saccharomicins, novel heptadecaglycoside antibiotics effective against multi-resistant bacteria. J. Am. Chem. Soc. 120: 13301-13311.
7. Marshall, A. J., and L. J. Piddock. 1994. Interaction of divalent cations, quinolones and bacteria. J. Antimicrob. Chemother. 34:465-483.
8. Miles, A. A., and J. P. Maskell. 1986. The neutralization of antibiotic action by metallic cations and iron chelators. J. Antimicrob. Chemother. 17:481-487.
9. National Committee for Clinical Laboratory Standards. 1991 Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically: approved standard M7-A. National Committee for Clinical Laboratory Standards, Villanova, Pa.
10. Novak, R., B. Henriques, E. Charpentier, S. Normark and and E. Tuomanen. 1999. Emergence of vancomycin tolerance in Streptococcus pneumoniae. Nature 399:590-593.
11. Okeke, I. N., A. Lamikanra, and R. Edelman. 1999. Socioeconomic and behavioral factors leading to acquired bacterial resistance to antibiotics in developing countries. Emerg. Infect. Dis. 5:18-27.
12. Perl, T. M. 1999, The threat of vancomycin resistance. Am. J. Med. 106: 26S-37S.
13. Sampson, B. A., R. Misra, and S. A. Benson. 1989. Identification and characterization of a new gene of Escherichia coli K-12 involved in outer membrane permeability. Genetics 122:491-501.
14. 2, a novel antibiotic produced by Streptomyces viridodiastaticus subsp. "litoralis" LL-3IF508. Antimicrob. Agents Chemother. 38:1808-1812.