Menkes protein contributes to the function of peptidylglycine α-amidating monooxygenase

Endocrinology

Volumn 144, Issue 1, 2003, Pages 188-200

  Steveson, Tami C ^a,d   Ciccotosto, Giuseppe D ^b   Ma, Xin Ming ^a   Mueller, Gregory P ^c   Mains, Richard E ^a   Eipper, Betty A ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^d BOWLING GREEN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMIDATING ENZYME; PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; HYPOPHYSIS CELL; MALE; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; WILD TYPE;

ADENOSINE TRIPHOSPHATASES; ADRENAL GLANDS; ADRENOCORTICOTROPIC HORMONE; ALPHA-MSH; ANIMALS; CATION TRANSPORT PROTEINS; CEREBRAL CORTEX; CHOLECYSTOKININ; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MIXED FUNCTION OXYGENASES; MULTIENZYME COMPLEXES; PITUITARY GLAND; PITUITARY GLAND, ANTERIOR; PRO-OPIOMELANOCORTIN; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0037225452     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2002-220716     Document Type: Article

References (100)

1. Eipper BA, Stoffers DA, Mains RE 1992 The biosynthesis of neuropeptides: Peptide α-amidation. Annu Rev Neurosci 15:57-85
2. Kaler SG 1994 Menkes disease (published erratum appears in 1995 Adv Pediatr 42:xxxi). Adv Pediatr 41:263-304
3. Mercer JF 1998 Menkes syndrome and animal models. Am J Clin Nutr 67:1022S-1028S
4. Pena MM, Lee J, Thiele DJ 1999 A delicate balance: Homeostatic control of copper uptake and distribution. J Nutr 129:1251-1260
5. Mercer JF 2001 The molecular basis of copper-transport diseases. Trends Mol Med 7:64-69
6. Camakaris J, Voskoboinik I, Mercer JF 1999 Molecular mechanisms of copper homeostasis. Biochem Biophys Res Commun 261:225-232
7. Harris ED 2000 Cellular copper transport and metabolism. Annu Rev Nutr 20:291-310
8. Huffman DL, O'Halloran TV 2001 Function, structure, and mechanism of intracellular copper trafficking proteins. Annu Rev Biochem 70:677-701
9. Chelly J, Tumer Z, Tonnesen T, Petterson A, Ishikawa-Brush Y, Tommerup N, Horn N, Monaco AP 1993 Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein. Nat Genet 3:14-19
10. Mercer JF, Livingston J, Hall B, Paynter JA, Begy C, Chandrasekharappa S, Lockhart P, Grimes A, Bhave M, Siemieniak D 1993 Isolation of a partial candidate gene for Menkes disease by positional cloning. Nat Genet 3:20-25
11. Petrukhin KF, Fischer SG, Pirastu MF, Tanzi RE, Chernov IF, Devoto MF, Brzustowicz LM, Cayanis E, Vitale E, Russo JJ 1993 Mapping, cloning and genetic characterization of the region containing the Wilson disease gene. Nat Genet 5:338-343
12. Vulpe C, Levinson B, Whitney S, Packman S, Gitschier J 1993 Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase (published erratum appears in 1993 Nat Genet 3:273). Nat Genet 3:7-13
13. Zhou B, Gitschier J 1997 hCTR1: A human gene for copper uptake identified by complementation in yeast. Proc Natl Acad Sci USA 94:7481-7486
14. Lee J, Pena M, Nose Y, Thiele DJ 2002 Biochemical characterization of the human copper transporter Ctr1. J Biol Chem 277:4380-4387
15. Lee J, Prohaska JR, Thiele DJ 2001 Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development. Proc Natl Acad Sci USA 98:6842-6847
16. Culotta VC, Klomp LW, Strain JF, Casareno RL, Krems BF, Gitlin JD 1997 The copper chaperone for superoxide dismutase. J Biol Chem 272:23469-23472
17. Rosenzweig AC 2001 Copper delivery by metallochaperone proteins. Acc Chem Res 34:119-128
18. Stewart LC, Klinman JP 1988 Dopamine beta-hydroxylase of adrenal chromaffin granules: Structure and function. Annu Rev Biochem 57:551-592
19. Oyarce AM, Fleming PJ 1991 Multiple forms of human dopamine beta-hydroxylase in SH-SY5Y neuroblastoma cells. Arch Biochem Biophys 290:503-510
20. Milgram SL, Kho ST, Martin GV, Mains RE, Eipper BA 1997 Localization of integral membrane peptidylglycine α-amidating monooxygenase in neuroendocrine cells. J Cell Sci 110:695-706
21. El Meskini RF, Galano GJ, Marx RF, Mains RE, Eipper BA 2001 Targeting of membrane proteins to the regulated secretory pathway in anterior pituitary endocrine cells. J Biol Chem 276:3384-3393
22. Yamaguchi Y, Heiny ME, Gitlin JD 1993 Isolation and characterization of a human liver cDNA as a candidate gene for Wilson disease. Biochem Biophys Res Commun 197:271-277
23. Harris ZL, Gitlin JD 1996 Genetic and molecular basis for copper toxicity. Am J Clin Nutr 63:836S-841S
24. Harrison MD, Jones CE, Solioz MF, Dameron CT 2000 Intracellular copper routing: The role of copper chaperones. Trends Biochem Sci 25:29-32
25. Mueller GP, Husten EJ, Mains RE, Eipper BA 1993 Peptide α-amidation and peptidylglycine α-hydroxylating monooxygenase: Control by disulfiram. Mol Pharmacol 44:972-980
26. Mains RE, Park LP, Eipper BA 1986 Inhibition of peptide amidation by disulfiram and diethyldithiocarbamate. J Biol Chem 261:11938-11941
27. Kumar AM, Agarwal RK, Thompson ML, Marchand JE, Kream RM, Engelking LR 1994 Effect of chronic DDC treatment on LHRH and substance P amidation processes in the rat. Brain Res Bull 33:337-344
28. Husten EJ, Eipper BA 1991 The membrane-bound bifunctional peptidylglycine α-amidating monooxygenase protein. Exploration of its domain structure through limited proteolysis. J Biol Chem 266:17004-17010
29. Jiang NF, Kolhekar AS, Jacobs PS, Mains RE, Eipper BA, Taghert PH 2000 PHM is required for normal developmental transitions and for biosynthesis of secretory peptides in Drosophila. Dev Biol 226:118-136
30. Taghert PH, Hewes RS, Park JH, O'Brien MA, Han M, Peck ME 2001 Multiple amidated neuropeptides are required for normal circadian locomotor rhythms in Drosophila. J Neurosci 21:6673-6686
31. Eipper BA, Myers AC, Mains RE 1985 Peptidyl-glycine α-amidation activity in tissues and serum of the adult rat. Endocrinology 116:2497-2504
32. Sakata J, Mizuno K, Matsuo H 1986 Tissue distribution and characterization of peptide C-terminal α-amidating activity in rat. Biochem Biophys Res Commun 140:230-236
33. Mains RE, Eipper BA 2001 POMC synthesis and cell-specific processing. In: American Physiology Society, ed. Handbook of Physiology. New York: Oxford Press, vol IV:85-101
34. Schnabel E, Mains RE, Farquhar MG 1989 Proteolytic processing of pro-ACTH/endorphin begins in the Golgi complex of pituitary corticotropes and AtT-20 cells. Mol Endocrinol 3:1223-1235
35. Eipper BA, Perkins SN, Husten EJ, Johnson RC, Keutmann HT, Mains RE 1991 Peptidyl-α-hydroxyglycine α-amidating lyase. Purification, characterization, and expression. J Biol Chem 266:7827-7833
36. Prigge SF, Kolhekar AS, Eipper BA, Mains RE, Amzel LM 1997 Amidation of bioactive peptides: The structure of peptidylglycine α-hydroxylating monooxygenase. Science 278:1300-1305
37. Petris MJ, Strausak D, Mercer JF 2000 The Menkes copper transporter is required for the activation of tyrosinase. Hum Mol Genet 9:2845-2851
38. Tumer Z, Horn N 1997 Menkes disease: Recent advances and new aspects. J Med Genet 34:265-274
39. Grimes A, Hearn CJ, Lockhart P, Newgreen DF, Mercer JF 1997 Molecular basis of the brindled mouse mutant (Mo(br)): A murine model of Menkes disease. Hum Mol Genet 6:1037-1042
40. Cunliffe P, Reed V, Boyd Y 2001 Intragenic deletions at Atp7a in mouse models for Menkes disease. Genomics 74:155-162
41. Milgram SL, Johnson RC, Mains RE 1992 Expression of individual forms of peptidylglycine α-amidating monooxygenase in AtT-20 cells: Endoproteolytic processing and routing to secretory granules. J Cell Biol 117:717-728
42. May V, Eipper BA 1986 Long-term culture of primary rat pituitary adrenocorticotropin/endorphin-producing cells in serum-free medium. Endocrinology 118:1284-1295
43. Oyarce AM, Eipper BA 1995 Identification of subcellular compartments containing peptidylglycine α-amidating monooxygenase in rat anterior pituitary. J Cell Sci 108:287-297
44. El Meskini R, Mains RE, Eipper BA2000 Cell type-specific metabolism of peptidylglycine α-amidating monooxygenase in anterior pituitary. Endocrinology 141:3020-3034
45. Eipper BA, Park L, Keutmann HT, Mains RE 1986 Amidation of joining peptide, a major pro-ACTH/endorphin-derived product peptide. J Biol Chem 261:8686-8694
46. Steveson TC, Keutmann HT, Mains RE, Eipper BA 1999 Phosphorylation of cytosolic domain Ser(937) affects both biosynthetic and endocytic trafficking of peptidylglycine α-amidating monooxygenase. J Biol Chem 274:21128-21138
47. Husten EJ, Tausk FA, Keutmann HT, Eipper BA 1993 Use of endoproteases to identify catalytic domains, linker regions, and functional interactions in soluble peptidylglycine α-amidating monooxygenase. J Biol Chem 268:9709-9717
48. Eipper BA, Quon AS, Mains RE, Boswell JS, Blackburn NJ 1995 The catalytic core of peptidylglycine α-hydroxylating monooxygenase: Investigation by site-directed mutagenesis, Cu X-ray absorption spectroscopy, and electron paramagnetic resonance. Biochemistry 34:2857-2865
49. Laemmli UK 1970 Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685
50. Bruzzaniti A, Marx R, Mains RE 1999 Activation and routing of membrane-tethered prohormone convertases 1 and 2. J Biol Chem 274:24703-24713
51. Ciccotosto GD, Schiller MR, Eipper BA, Mains RE 1999 Induction of Integral membrane PAM expression in AtT-20 cells alters the storage and trafficking of POMC and PC1. J Cell Biol 144:459-471
52. Wang W, Cain BM, Beinfeld MC 1998 Adult carboxypeptidase E-deficient fat/fat mice have a near-total depletion of brain CCK 8 accompanied by a massive accumulation of glycine and arginine extended CCK: Identification of CCK 8 Gly as the immediate precursor of CCK 8 in rodent brain. Endocrine 9:329-332
53. McPherson CE, Eipper BA, Mains RE 2002 Genomic organization and differential expression of Kalirin isoforms. Gene 284:41-51
54. Cryer PE 1976 Isotope-derivative measurements of plasma norepinephrine and epinephrine in man. Diabetes 25:1071-1082
55. Cryer PE 1980 Physiology and pathophysiology of the human sympathoadrenal neuroendocrine system. N Engl J Med 303:436-444
56. La Fontaine S, Firth SD, Lockhart PJ, Brooks H, Parton RG, Camakaris J, Mercer JF 1998 Functional analysis and intracellular localization of the human Menkes protein (MNK) stably expressed from a cDNA construct in Chinese hamster ovary cells (CHO-K1). Hum Mol Genet 7:1293-1300
57. Francis MJ, Jones EE, Levy ER, Ponnambalam S, Chelly J, Monaco AP 1998 A Golgi localization signal identified in the Menkes recombinant protein. Hum Mol Genet 7:1245-1252
58. Dierick HA, Adam AN, Escara-Wilke JF, Glover TW 1997 Immunocytochemical localization of the Menkes copper transport protein (ATP7A) to the trans-Golgi network. Hum Mol Genet 6:409-416
59. Petris MJ, Mercer JF, Culvenor JG, Lockhart P, Gleeson PA, Camakaris J 1996 Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: A novel mechanism of regulated trafficking. EMBO J 15:6084-6095
60. Yamaguchi Y, Heiny ME, Suzuki M, Gitlin JD 1996 Biochemical characterization and intracellular localization of the Menkes disease protein. Proc Natl Acad Sci USA 93:14030-14035
61. Goodyer ID, Jones EE, Monaco AP, Francis MJ 1999 Characterization of the Menkes protein copper-binding domains and their role in copper-induced protein relocalization. Hum Mol Genet 8:1473-1478
62. Petris MJ, Mercer JF 1999 The Menkes protein (ATP7A; MNK) cycles via the plasma membrane both in basal and elevated extracellular copper using a C-terminal di-leucine endocytic signal. Hum Mol Genet 8:2107-2115
63. Petris MJ, Camakaris J, Greenough M, LaFontaine S, Mercer JB 1998 A C-terminal di-leucine is required for localization of the Menkes protein in the trans-Golgi network. Hum Mol Genet 7:2063-2071
64. Nagara H, Yajima K, Suzuki K 1981 The effect of copper supplementation on the brindled mouse: A clinico-pathological study. J Neuropathol Exp Neurol 40:428-446
65. Fujii T, Ito M, Tsuda H, Mikawa H 1990 Biochemical study on the critical period for treatment of the mottled brindled mouse. J Neurochem 55:885-889
66. Mercer JF, Ambrosini L, Horton S, Gazeas S, Grimes A 1999 Animal models of Menkes disease. Adv Exp Med Biol 448:97-108
67. Eipper BA, Green CB, Campbell TA, Stoffers DA, Keutmann, HT, Mains RE, Ouafik L 1992 Alternative splicing and endoproteolytic processing generate tissue-specific forms of pituitary peptidylglycine α-amidating monooxygenase (PAM). J Biol Chem 267:4008-4015
68. Prigge S, Mains RE, Eipper BA, Amzel LM 2000 New insights into copper monooxygenases and peptide amidation: Structure, mechanism and function. Cell Mol Life Sci 57:1236-1259
69. Jaron S, Blackburn NJ 2001 Characterization of a half-apo derivative of peptidylglycine monooxygenase. Biochemistry 40:6867-6875
70. Sato SM, Mains RE 1987 The synthesis and processing of pro-ACTH/endorphin in the developing rat pituitary. Ann NY Acad Sci 512:286-299
71. Marcinkiewicz M, Day R, Seidah NG, Chretien M 1993 Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin. Proc Natl Acad Sci USA 90:4922-4926
72. Rehfeld JF 2000 Cholecystokinin and panic disorder - Three unsettled questions. Regul Pept 93:79-83
73. Sarkar B 1999 Treatment of Wilson and Menkes diseases. Chem Rev 99:2535-2544
74. Martins LJ, Jensen LT, Simon JR, Keller GL, Winge DR, Simons JR 1998 Metalloregulation of FRE1 and FRE2 homologs in Saccharomyces cerevisiae. J Biol Chem 273:23716-23721
75. Glerum DM, Shtanko A, Tzagoloff A 1996 Characterization of COX17, a yeast gene involved in copper metabolism and assembly of cytochrome oxidase. J Biol Chem 271:14504-14509
76. Klomp LW, Lin SJ, Yuan DS, Klausner RD, Culotta VC, Gitlin JD 1997 Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis. J Biol Chem 272:9221-9226
77. Casareno RL, Waggoner D, Gitlin JD 1998 The copper chaperone CCS directly interacts with copper/zinc superoxide dismutase. J Biol Chem 273:23625-23628
78. Hung IH, Casareno RL, Labesse G, Mathews FS, Gitlin JD 1998 HAH1 is a copper-binding protein with distinct amino acid residues mediating copper homeostasis and antioxidant defense. J Biol Chem 273:1749-1754
79. Ogi KF, Kimura CF, Onda HF, Arimura AF, Fujino M 1990 Molecular cloning and characterization of cDNA for the precursor of rat pituitary adenylate cyclase activating polypeptide (PACAP). Biochem Biophys Res Commun 173:1271-1279
80. Hyde JF, Moore Jr JP, Cai A 1998 Galanin in normal and hyperplastic anterior pituitary cells. Ann NY Acad Sci 863:48-55
81. Kistler-Heer V, Lauber ME, Lichtensteiger W 1998 Different developmental patterns of melanocortin MC3 and MC4 receptor mRNA: Predominance of Mc4 in fetal rat nervous system. J Neuroendocrinol 10:133-146
82. Terada K, Schilsky ML, Miura N, Sugiyama T 1998 ATP7B (WND) protein. Int J Biochem Cell Biol 30:1063-1067
83. Daly C, Ziff EB 1997 Post-transcriptional regulation of synaptic vesicle protein expression and the developmental control of synaptic vesicle formation. J Neurosci 17:2365-2375
84. Caldwell BD, Darlington DN, Penzes P, Johnson RC, Eipper BA, Mains RE 1999 The novel kinase peptidylglycine α-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine α-amidating monooxygenase. J Biol Chem 274:34646-34656
85. Tausk FA, Milgram SL, Mains RE, Eipper BA 1992 Expression of a peptide processing enzyme in cultured cells: Truncation mutants reveal a routing domain. Mol Endocrinol 6:2185-2196
86. Reed V, Boyd Y 1997 Mutation analysis provides additional proof that mottled is the mouse homologue of Menkes' disease. Hum Mol Genet 6:417-423
87. Fewell SW, Travers KJ, Weissman JS, Brodsky JL 2001 The action of molecular chaperones in the early secretory pathway. Annu Rev Genet 35:149-191
88. Muglia LJ, Jacobson LF, Luedke CF, Vogt SK, Schaefer ML, Dikkes PF, Fukuda S, Sakai YF, Suda TF, Majzoub JA 2000 Corticotropin-releasing hormone links pituitary adrenocorticotropin gene expression and release during adrenal insufficiency. J Clin Invest 105:1269-1277
89. Sato SM, Mains RE 1985 Posttranslational processing of proadrenocorticotropin/endorphin-derived peptides during postnatal development in the rat pituitary. Endocrinology 117:773-786
90. Strand FL 1999 New vistas for melanocortins. Ann NY Acad Sci 897:1-16
91. Beinfeld MC 1997 CCK biosynthesis and processing: Recent progress and future challenges. Life Sci 61:2359-2366
92. Beinfeld MC, Perloff MD, Venkatakrishnan K 1998 Identification of glycine-extended CCK peptides in endocrine cells and modulation of CCK amide and CCK Gly content and secretion from endocrine tumor cells by an inhibitor of amidation. Peptides 19:1393-1398
93. Marino L, Muglia B, Dickinson CJ 1994 Glycine-extended post-translational processing intermediates of gastrin and cholecystokinin in the gut. Regul Pept 50:73-85
94. Demeneix B, Grant NJ 1988 α-Melanocyte stimulating hormone promotes neurite outgrowth in chromaffin cells. FEBS Lett 226:337-342
95. van der Neut R, Hol EM, Gispen WH, Bar PR 1992 Stimulation by melanocortins of neurite outgrowth from spinal and sensory neurons in vitro. Peptides 13:1109-1115
96. Strand FL, Zuccarelli LA, Williams KA. Lee SJ, Lee TS, Antonawich FJ, Alves SE 1993 Melanotropins as growth factors. Ann NY Acad Sci 680:29-50
97. Joosten EA, Verhaagh S, Martin D, Robe P, Franzen R, Hooiveld M, Doornbos R, Bar PR, Moonen G 1996 α-MSH stimulates neurite outgrowth of neonatal rat corticospinal neurons in vitro. Brain Res 736:91-98
98. Gonzalez BJ, Basille M, Vaudry D, Fournier A, Vaudry H 1997 Pituitary adenylate cyclase-activating polypeptide promotes cell survival and neurite outgrowth in rat cerebellar neuroblasts. Neuroscience 78:419-430
99. Vaudry D, Gonzalez BJ, Basille M, Fournier A, Vaudry H 1999 Neurotrophic activity of pituitary adenylate cyclase-activating polypeptide on rat cerebellar cortex during development. Proc Natl Acad Sci USA 96:9415-9420
100. Hansel DE, May V, Eipper BA, Ronnett GV 2001 Pituitary adenylyl cyclase-activating peptides and α-amidation in olfactory neurogenesis and neuronal survival in vitro. J Neurosci 21:4625-4636