Site-specific cleavage of human telomerase RNA using PNA-neocuproine·Zn(II) derivatives

Chemical Communications

Volumn , Issue 1, 2003, Pages 36-37

  Whitney, Andrew ^a   Gavory, Gérald ^a   Balasubramanian, Shankar ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,9 DIMETHYL 1,10 PHENANTHROLINE; RNA; TELOMERASE; ZINC DERIVATIVE;

ARTICLE; CONTROLLED STUDY; HUMAN; RNA CLEAVAGE; SYNTHESIS;

EID: 0037223087     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/b210135a     Document Type: Article

References (29)

1. (a) B. N. Trawick, A. T. Daniher and J. K. Bashkin, Chem. Rev., 1998, 98, 939;
2. (b) M. Komiyama, J. Sumaoka, A. Kuzuya and Y. Yamamoto, Methods Enzymol., 2001, 341, 455-468.
3. (a) J. K. Bashkin, E. I. Frolova and U. Sampath, J. Am. Chem. Soc., 1994, 116, 5981-5982;
4. (b) J. Hall, D. Huesken and R. Haener, Nucleic Acids Res., 1996, 24, 3522-26;
5. (c) D. Magda, M. Wright, S. Crofts A. Lin and J. L. Sessler, J. Am. Chem. Soc., 1997, 119, 6947-6948;
6. (d) W. C. Putnam, A. T. Daniher, B. N. Trawick and J. K. Bashkin, Nucleic Acids Res., 2001, 29, 2199-2204.
7. (a) M. Komiyama and T. Inokawa, J. Biochem., 1994, 166, 719-720;
8. (b) M. A. Reynolds, T. A. Beck, P. B. Say, D. A. Schwartz, B. P. Dwyer, W. J. Daily, M. M. Vaghefi, M. D. Metzler, R. E. Klem and L. J. Arnold Jr., Nucleic Acids Res., 1996, 24, 760-5;
9. (c) V. Vlassov, T. Abramova, T. Godovikova, R. Giege and V. Silnikov, Antisense Nucleic Acid Drug Dev., 1997, 7, 39-42;
10. (d) M. Endo, Y. Azuma, Y. Saga, A. Kuzuya, G. Kawai and M. Komiyama, J. Org. Chem., 1997, 62, 846-52.
11. J. Hall, D. Huesken, U. Pieles, H. E. Moser and R. Haener, Chem. Biol., 1994, 1, 185-190.
12. J. C. Verheijen, B. A. L. M. Dieman, E. Yeheskieky, G. A. van der Marel and J. H. van Boom, Angew. Chem., Int. Ed., 2000, 39, 369-372.
13. A. Kuzuya, R. Mizoguchi, F. Morisawa, K. Machida and M. Komiyama, J. Am. Chem. Soc., 2002, 124, 6887-6894.
14. N. G. Beloglazova, V. N. Silni'kov, M. A. Zenkova and V. V. Vlassov, FEBS Lett., 2000, 481, 277-280.
15. W. C. Putnam and J. K. Bashkin, Chem. Commun., 2000, 767-768.
16. 8.
17. V. V. Demidov, V. N. Potaman, M. D. F. Kamenetskii, M. Egholm, O. Bushart, S. H. Sonnischsen and P. E. Nielsen, Biochem. Pharmacol., 1994, 48, 1310-1313.
18. B. Hyrup and P. E. Nielsen, Bioorg. Med. Chem., 1996, 4, 5-23.
19. J. L. Chen, M. A. Blasco and C. W. Greider, Cell, 2000, 100, 503-514.
20. G. W. Greider and E. H. Blackburn, Cell, 1985, 42, 405.
21. N. W. Kim, Eur. J. Cancer, 1997, 33, 781.
22. S. E. Hamilton, C. G. Simmons, I. S. Kathiriya and D. R. Corey, Chem. Biol., 1999, 6, 343-351.
23. J. G. Harrison, C. Frier, R. Laurant, R. Dennis, K. D. Raney and S. Balasubramanian, Bioorg. Med. Chem. Lett., 1999, 9, 1273-1278.
24. A. N. Elayadi, D. A. Braash and D. R. Corey, Biochemistry, 2002, 41, 9973-9981.
25. Y. Yokoyama, Y. Takahashi, A. Shinohara, Z. L. Lian, X. Y. Wan, K. Niwa and T. Tamaya, Cancer Res., 1998, 58, 5406-5410.
26. N.
27. Cleavage efficiency based on three independent experiments.
28. In order to better resolve the cleavage products from starting material using electrophoresis.
29. Cleavage efficiency based on two independent experiments.