Carotid body denervation eliminates apnea in response to transient hypocapnia

Journal of Applied Physiology

Volumn 94, Issue 1, 2003, Pages 155-164

  Nakayama, Hideaki ^a   Smith, Curtis A ^a,b   Rodman, Joshua R ^a   Skatrud, James B ^a   Dempsey, Jerome A ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b John Rankin Laboratory of Pulmonary Medicine   (United States)

Author keywords

Central apnea; Central chemoreceptors; Mechanical ventilation; Non rapid eye movement sleep; Sleep disordered breathing; Ventilatory overshoot

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; APNEA; ARTICLE; ARTIFICIAL VENTILATION; BREATHING; CARBON DIOXIDE TENSION; CAROTID BODY; CAROTID BODY CHEMORECEPTOR; CONTROLLED STUDY; DENERVATION; DOG; FEMALE; HYPEROXIA; HYPOCAPNIA; NONHUMAN; NONREM SLEEP; PRIORITY JOURNAL; SLEEP APNEA SYNDROME; TIDAL VOLUME;

EID: 0037216295     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00722.2002     Document Type: Article

References (49)

1. 2. Pflügers Arch 395: 285-292, 1982.
2. Andreas S, Weidel K, Hagenah G, and Heindl S. Treatment of Cheyne-Stokes respiration with nasal oxygen and carbon dioxide. Eur Respir J 12: 414-419, 1998.
3. Badr MS, Grossman JE, and Weber SA. Treatment of refractory sleep apnea with supplemental carbon dioxide. Am J Respir Crit Care Med 150: 561-564, 1994.
4. Badr MS, Toiber F, Skatrud JB, and Dempsey J. Pharyngeal narrowing/occlusion during central sleep apnea. J Appl Physiol 78: 1806-1815, 1995.
5. Bajic J, Zuperku EJ, Tonkovic-Capin M, and Hopp FA. Interaction between chemoreceptor and stretch receptor inputs at medullary respiratory neurons. Am J Physiol Regul Integr Comp Physiol 266: R1951-R1961, 1994.
6. Ballantyne D and Scheid P. Central chemosensitivity of respiration: A brief overview. Respir Physiol 129: 5-12, 2001.
7. Berssenbrugge A, Dempsey J, Iber C, Skatrud J, and Wilson P. Mechanisms of hypoxia-induced periodic breathing during sleep in humans. J Physiol 343: 507-526, 1983.
8. 2 on depth and rate of breathing in decerebrate cats. Respir Physiol 30: 311-325, 1977.
9. Bowes G, Audrey SM, Kozar LF, and Phillipson EA. Carotid chemoreceptor regulation of expiratory duration. J Appl Physiol 54: 1195-1201, 1983.
10. 2 in the awake lamb: Role of the carotid chemoreceptors. J Appl Physiol 71: 2198-2205, 1991.
11. Cherniack NS and Longobardo GS. Cheyne-Stokes breathing. An instability in physiologic control. N Engl J Med 288: 952-957, 1973.
12. Chow CM, Xi L, Smith CA, Saupe KW, and Dempsey JA. A volume-dependent apneic threshold during NREM sleep in the dog. J Appl Physiol 76: 2315-2325, 1994.
13. Cohen MI. Tonic chemoreceptor input as the background for respiratory rhythm. In: Ventral Brainstem Mechanisms and Control of Respiration and Blood Pressure, edited by Trouth CO, Millis RM, and Kiwull-Schone KF. New York: Dekker, 1995, p. 797-799.
14. Cross BA, Grant BJ, Guz A, Jones PW, Semple SJ, and Stidwell RP. Dependence of phrenic motoneurone output on the oscillatory component of arterial blood gas composition. J Physiol 290: 163-184, 1979.
15. Curran AK, Rodman JR, Eastwood PR, Henderson KS, Dempsey JA, and Smith CA. Ventilatory responses to specific CNS hypoxia in sleeping dogs. J Appl Physiol 88: 1840-1852, 2000.
16. Eldridge FL, Kiley JP, and Paydarfar D. Dynamics of medullary hydrogen ion and respiratory responses to square-wave change of arterial carbon dioxide in cats. J Physiol 385: 627-642, 1987.
17. Eldridge FL and Millhorn DE. Oscillation, gating, and memory in the respiratory control system. In: Handbook of Physiology. The Respiratory System. Control of Breathing. Bethesda, MD: Am. Physiol. Soc., 1986, sect. 3, vol. II, pt. 1, chapt. 3, p. 93-114.
18. Fencl V, Miller TB, and Pappenheimer JR. Studies on the respiratory response to disturbances of acid-base balance, with deductions concerning the ionic composition of cerebral interstitial fluid. Am J Physiol 210: 459-472, 1966.
19. Fitzgerald RS, Zajtchuk JT, Penman RWB, and Perkins J. Ventilatory response to transient perfusion of the carotid chemoreceptors. Am J Physiol 207: 1305-1313, 1964.
20. Forster HV, Pan LG, Lowry TF, Feroah T, Gershan WM, Whaley AA, Forster MM, and Sprtel B. Breathing of awake goats during prolonged dysfunction of caudal M ventrolateral medullary neurons. J Appl Physiol 84: 129-140, 1998.
21. Franklin KA, Eriksson P, Sahlin C, and Lundgren R. Reversal of central sleep apnea with oxygen. Chest 111: 163-169, 1997.
22. Gautier H and Bonora M. Effects of carotid body denervation on respiratory pattern of awake cats. J Appl Physiol 46: 1127-1131, 1979.
23. Javaheri S. Central sleep apnea-hypopnea syndrome in heart failure: Prevalence, impact, and treatment. Sleep 19: 229-231, 1996.
24. Javaheri S. A mechanism of central sleep apnea in patients with heart failure. N Engl J Med 341: 949-954, 1999.
25. Kiley JP, Eldridge FL, and Millhorn DE. The roles of medullary extracellular and cerebrospinal fluid pH in control of respiration. Respir Physiol 59: 117-130, 1985.
26. Lahiri S and DeLaney RG. Stimulus interaction in the responses of carotid body chemoreceptor single afferent fibers. Respir Physiol 24: 249-266, 1975.
27. Lorenzi-Filho G, Rankin F, Bies I, and Douglas Bradley T. Effects of inhaled carbon dioxide and oxygen on Cheyne-Stokes respiration in patients with heart failure. Am J Respir Crit Care Med 159: 1490-1498, 1999.
28. Meza S, Mendez M, Ostrowski M, and Younes M. Susceptibility to periodic breathing with assisted ventilation during sleep in normal subjects. J Appl Physiol 85: 1929-1940, 1998.
29. Millhorn DE, Eldridge FL, and Kiley JP. Oscillations of medullary extracellular fluid pH caused by breathing. Respir Physiol 55: 193-203, 1984.
30. 2 sensitivity below eupnea during sleep. Am J Respir Crit Care Med 165: 1251-1259, 2002.
31. Nattie E. Multiple sites for central chemoreception: Their roles in response sensitivity and in sleep and wakefulness. Respir Physiol 122: 223-235, 2000.
32. 2 dialysis in the medullary raphe of the rat increases ventilation in sleep. J Appl Physiol 90: 1247-1257, 2001.
33. Naughton M, Benard D, Tam A, Rutherford R, and Bradley TD. Role of hyperventilation in the pathogenesis of central sleep apneas in patients with congestive heart failure. Am Rev Respir Dis 148: 330-338, 1993.
34. Naughton MT and Bradley TD. Sleep apnea in congestive heart failure. Clin Chest Med 19: 99-113, 1998.
35. Okada Y, Chen Z, Jiang W, Kuwana S, and Eldridge FL. Anatomical arrangement of hypercapnia-activated cells in the superficial ventral medulla of rats. J Appl Physiol 93: 427-439, 2002.
36. Pappenheimer JR, Fencl V, Heisey SR, and Held D. Role of cerebral fluids in control of respiration as studied in unanesthetized goats. Am J Physiol 208: 436-450, 1965.
37. Richerson GB, Wang W, Tiwari J, and Bradley SR. Chemosensitivity of serotonergic neurons in the rostral ventral medulla. Respir Physiol 129: 175-189, 2001.
38. Rodman JR, Curran AK, Henderson KS, Dempsey JA, and Smith CA. Carotid body denervation in dogs: Eupnea and the ventilatory response to hyperoxic hypercapnia. J Appl Physiol 91:328-335, 2001.
39. Satoh M, Eastwood PR, Smith CA, and Dempsey JA. Nonchemical elimination of inspiratory motor output via mechanical ventilation in sleep. Am J Respir Crit Care Med 163: 1356-1364, 2001.
40. See WR, Schlaefke ME, and Loeschcke HH. Role of chemical afferents in the maintenance of rhythmic respiratory movements. J Appl Physiol 54: 453-459, 1983.
41. Siesjo B. The regulation of cerebrospinal fluid pH. Kidney Int 1: 360-374, 1972.
42. Smith CA, Saupe KW, Henderson KS, and Dempsey JA. Ventilatory effects of specific carotid body hypocapnia in dogs during wakefulness and sleep. J Appl Physiol 79: 689-699, 1995.
43. Solin P, Roebuck T, Johns DP, Walters EH, and Naughton MT. Peripheral and central ventilatory responses in central sleep apnea with and without congestive heart failure. Am J Respir Crit Care Med 162: 2194-2200, 2000.
44. 2 oscillations on respiratory control at rest. J Appl Physiol 70: 1601-1606, 1991.
45. 2 in congestive heart failure patients with and without central sleep apnea. J Appl Physiol 91:408-416, 2001.
46. Xie A, Puleo DS, Dempsey JA, and Skatrud JB. Peripheral chemoreceptor and post-hyperventilation apnea (Abstract). Am J Respir Crit Care Med 165: A669, 2002.
47. 2 and added dead space on idiopathic central sleep apnea. J Appl Physiol 82: 918-926, 1997.
48. 2 in sleeping humans. J Physiol 535: 269-278, 2001.
49. Xie A, Wong B, Phillipson EA, Slutsky AS, and Bradley TD. Interaction of hyperventilation and arousal in the pathogenesis of idiopathic central sleep apnea. Am J Respir Crit Care Med 150:489-495, 1994.