Mutations in the gene for toll-like receptor 4 and multiple sclerosis

Tissue Antigens

Volumn 61, Issue 1, 2003, Pages 85-88

  Reindl, Markus ^a   Lutterotti, A ^a   Ingram, J ^b   Schanda, K ^a   Gassner, C ^c   Deisenhammer, F ^a   Berger, T ^a   Lorenz, E ^b  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

Author keywords

DNA polymorphism; Multiple sclerosis; Toll like receptor 4

Indexed keywords

TOLL LIKE RECEPTOR 4;

ADULT; ALLELE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; INFLAMMATION; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL;

ALLELES; CELL ADHESION MOLECULES; FEMALE; GENE FREQUENCY; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MULTIPLE SCLEROSIS; MUTATION; POLYMORPHISM, GENETIC; RECEPTORS, CELL SURFACE; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

BACTERIA (MICROORGANISMS);

EID: 0037215764     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0039.2003.610108.x     Document Type: Article

References (24)

1. Noseworthy JH, Lucchinetti C, Rodriguez M et al. Multiple sclerosis. N Engl J Med 2000: 343: 938-52.
2. Rocken M, Urban JF, Shevach EM. Infection breaks T-cell tolerance. Nature 1992: 359: 79-82.
3. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997: 388: 394-7.
4. Chow JC, Young DW, Golenbock DT et al. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 1999: 274: 10689-92.
5. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2001: 2: 675-80.
6. Lehnardt S, Lachance C, Patrizi S et al. The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS. J Neurosci 2002: 22: 2478-86.
7. Jacobson S, Cross A. Association of Chlamydia pneumoniae and multiple sclerosis: stage two? Neurology 2001: 56: 1128-9.
8. Ehl S, Hombach J, Aichele P et al. Viral and bacterial infections interfere with peripheral tolerance induction and activate CD8+ T cells to cause immunopathology. J Exp Med 1998: 187: 763-74.
9. Matyszak MK. Inflammation in the CNS. balance between immunological privilege and immune responses. Prog Neurobiol 1998: 56: 19-35.
10. Arbour NC, Lorenz E, Schutte BC et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000: 25: 187-91.
11. Beutler B, Poltorak A. Sepsis and evolution of the innate immune response. Crit Care Med 2001: 29: S2-6; discussion S6-7.
12. Lorenz E, Mira JP, Frees KL et al. Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med 2002: 162: 1028-32.
13. Lorenz E, Hallmann M, Marttila R et al. Association between the Asp299Gly polymorphisms in the toll-like receptor 4 and premature births in the Finnish population. Pediatrics Res 2002: 52: 373-6.
14. Kiechl S, Lorenz E, Reindl M et al. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 2002: 347: 185-92.
15. Sawcer S, Jones HB, Feakes R et al. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat Genet 1996: 13: 464-8.
16. Ebers GC, Kukay K. Bulman DE et al. A full genome search in multiple sclerosis. Nat Genet 1996: 13: 472-6.
17. Haines JL, Ter-Minassian M, Bazyk A et al. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex. The Multiple Sclerosis Genetics Group. Nat Genet 1996: 13: 469-71.
18. Kuokkanen S, Sundvall M, Terwilliger JD et al. A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2. Nat Genet 1996: 13: 477-80.
19. Archelos JJ, Hartung HP. The role of adhesion molecules in multiple sclerosis: biology, pathogenesis and therapeutic implications. Mol Med Today 1997: 3: 310-21.
20. Fazekas F, Strasser-Fuchs S, Kollegger H et al. Apolipoprotein E epsilon 4 is associated with rapid progression of multiple sclerosis. Neurology 2001: 57: 853-7.
21. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983: 33: 1444-52.
22. Lorenz E, Frees KL. Schwartz DA. Determination of the TLR4 genotype using allele-specific PCR. Biotechniques 2001: 31: 22-4.
23. Lidral AC, Romitti PA, Basart AM et al. Association of MSX1 and TGFB3 with nonsyndromic clefting in humans. Am J Hum Genet 1998: 63: 557-68.
24. A. comprehensive genetic linkage map of the human genome. NIH/CEPH Collaborative Mapping Group. Science 1992: 258: 67-86.