Different hepatitis B virus core gene mutations in children with chronic infection and hepatocellular carcinoma

Gut

Volumn 52, Issue 1, 2003, Pages 122-125

  Ni, Y H ^b   Chang, M H ^a,b   Hsu, H Y ^b   Tsuei, D J ^b  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B(E) ANTIGEN;

ADOLESCENT; ARTICLE; BLOOD SAMPLING; CHILD; CHILDHOOD CANCER; CHRONIC HEPATITIS; CODON; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE MUTATION; GENE SEQUENCE; HEPATITIS B VIRUS; HUMAN; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SERODIAGNOSIS; VIRUS GENE;

ADOLESCENT; ALANINE TRANSAMINASE; CARCINOMA, HEPATOCELLULAR; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; CODON; DNA MUTATIONAL ANALYSIS; FEMALE; FOLLOW-UP STUDIES; HEPATITIS B CORE ANTIGENS; HEPATITIS B, CHRONIC; HUMANS; LIVER NEOPLASMS; LOGISTIC MODELS; MALE; MUTATION;

EID: 0037214364     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.52.1.122     Document Type: Article

References (31)

1. Blum HE. Variations of hepatitis B, C, and D viruses: Molecular biology and clinical significance. Digestion 1995;56:85-95.
2. Hsu HY, Chang MH, Lee CY, et al. Precore mutant of hepatitis B virus in childhood fulminant hepatitis B: An infrequent association. J Infect Dis 1995;171:776-81.
3. Omata M, Ehata T, Yokosuka O, et al. Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. N Engl J Med 1991;324:1699-704.
4. Friedt M, Gerner P, Lausch E, et al. Mutations in the basic core promotor and the precore region of hepatitis B virus and their selection in children with fulminant and chronic hepatitis B. Hepatology 1999;29:1252-8.
5. Fujisawa T, Inui A, Komatsu H, et al. Hepatitis B precore mutant in children with chronic hepatitis B virus infection. Pediatr Int 1999;41:603-8.
6. Chuang WL, Omata M, Ehata T. Precore mutations and core clustering mutations in chronic hepatitis B virus infection. Gastroenterology 1993;104:263-71.
7. Bortolotti F, Crivellaro C, Brunetto MR, et al. Selection of a precore mutant of hepatitis 8 virus and reactivation of chronic hepatitis B acquired in children. J Pediatr 1993;123:583-5.
8. Zhong S, Chan JY, Yeo W, et al. Frequent integration of precore/core mutants of hepatitis B virus in human hepatocellular carcinoma tissues. J Viral Hepat 2000;7:115-23.
9. Chang MH, Hsu HY, Ni YH, et al. Precore stop codon mutant in chronic hepatitis B virus infection in children: Its relation to hepatitis B e seroconversion and maternal hepatitis B surface antigen. J Hepatol 1998;28:915-22.
10. Mondelli M, Vergani GM, Alberti A, et al. Specificity of T lymphocyte cytotoxicity to auologous hepatocytes in chronic hepatitis B virus infection: Evidence that T cells are directed against HBV core antigen expressed on hepatocytes. J Immunol 1982;129:2773-8.
11. Hsu HY, Chang MH, Hsieh KH, et al. Cellular immune response to hepatitis B core antigen in maternal-infant transmission of hepatitis B virus. Hepatology 1992;15:770-6.
12. Ferrari C, Penna A, Giuberti T, et al. Intrahepatic, nucleocapsid antigen-specific T cells in chronic active hepatitis B. J Immunol 1987;139:2050-8.
13. Bozkaya H, Akarca US, Ayola B, et al. High degree of conservation in the hepatitis B virus core gene during the immune tolerant phase in perinatally acquired chronic hepatitis B infection. J Hepatol 1997;26:508-16.
14. Akarca US, Lok ASF. Naturally occurring hepatitis B virus core gene mutations. Hepatology 1995;22:50-60.
15. Fujiwara K, Yokosuka O, Ehata T, et al. The two different states of hepatitis B virus DNA in asymptomatic carriers: HBe-antigen-positive versus anti-HBe-positive asymptomatic carriers. Dig Dis Sci 1998;43:368-76.
16. Hsu HY, Chang MH, Chen DS, et al. Baseline seroepidemiology of hepatitis B virus infection in children in Taipei, 1984: A study just before mass hepatitis B vaccination program in Taiwan. J Med Virol 1986;18:301-7.
17. Ni YH, Chang MH, Hsu HY, et al. Hepatocellular carcinoma in childhood. Cancer 1991;68:1737-41.
18. Hosono S, Tai PC, Wang W, et al. Core antigen mutations of human hepatitis B virus in hepatomas accumulate in MHC class II-restricted T cell epitopes. Virology 1995;212:151-62.
19. Ni YH, Chang MH, Hsu HY, et al. Long-term follow-up study of core gene deletion mutants in children with chronic hepatitis B virus infection. Hepatology 2000;32:124-8.
20. Kao JH, Chen PJ, Lai MY, et al. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology 2000;118:554-9.
21. Hasegawa K, Huang JK, Wands JR, et al. Association of hepatitis B viral precore mutations with fulminant hepatitis in Japan. Virology 1991;185:460-3.
22. Hur GM, Lee YI, Suh DJ, et al. Gradual accumulation of mutations in precore core region of HBV in patients with chronic active hepatitis: Implications of clustering changes in a small region of HBV core region. J Med Virol 1996;48:38-46.
23. Maini MK, Bertoletti A. How can the cellular immune response control hepatitis B virus replication? J Viral Hepat 2000;7:321-6.
24. Bertoletti A, Chisari FV, Penna A, et al. Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein. J Virol 1993;67:2376-80.
25. Ferrari C, Bertoletti A, Penna A, et al. Identification of immunodominant T cell epitopes of the hepatitis B virus nucleocapsid antigen. J Clin Invest 1991;88:214-22.
26. Bertoletti A, Sette A, Chisari FV, et al. Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells. Nature 1994;369:407-10.
27. Missale G, Redeker A, Person J, et al. HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis. J Exp Med 1993;177:751-62.
28. Schepis F, Verucchi G, Pollicino T, et al. Outcome of liver disease and response to interferon treatment are not influenced by hepatitis B virus core gene variability in children with chronic type B hepatitis. J Hepatol 1997;26:765-70.
29. Minami M, Poussin K, Kew M, et al. Precore/core mutations of hepatitis B virus in hepatocellular carcinomas developed on noncirrhotic livers. Gastroenterology 1996;111:691-700.
30. Tordjeman M, Fontan G, Rabillon V, et al. Characterization of minor and major antigenic regions within the hepatitis B virus nucleocapsids. J Med Virol 1993;41:221-9.
31. Raimondo G, Burk R, Lieberman H, et al. Interrupted replication of hepatitis B virus in liver tissue of HBsAg carriers with hepatocellular carcinoma. Virology 1988;166:103-12.