The two different states of hepatitis B virus DNA in asymptomatic carriers: HBe-antigen-positive versus anti-HBe-positive asymptomatic carriers

Digestive Diseases and Sciences

Volumn 43, Issue 2, 1998, Pages 368-376

  Fujiwara, Keiichi ^b   Yokosuka, Osamu ^a   Ehata, Toshiki ^b   Chuang, Wan Long ^b   Imazeki, Fumio ^b   Saisho, Hiromitsu ^b   Omata, Masao ^b  

^a CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NONE

Author keywords

Asymptomatic carrier; HBeAb; HBeAg; Hepatitis B virus DNA; Precore core gene

Indexed keywords

HEPATITIS B(E) ANTIBODY; HEPATITIS B(E) ANTIGEN; VIRUS DNA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; MALE; MISSENSE MUTATION; PRIORITY JOURNAL;

ADULT; CARRIER STATE; DNA, VIRAL; FEMALE; HEPATITIS B; HEPATITIS B CORE ANTIGENS; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HUMANS; MALE; MIDDLE AGED; MUTATION; NUCLEIC ACID HYBRIDIZATION; POLYMERASE CHAIN REACTION;

EID: 0031915984     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018870709286     Document Type: Article

References (40)

1. Hoofnagle JH, Shafritz DA, Popper H: Chronic type B hepatitis and the "healthy" HBeAg carrier state. Hepatology 7:758-763, 1987
2. Shikata T, Karasawa T, Abe T, Uzawa T, Suzuki H, Oda T, Imai M, Mayumi M, Moritsugu Y: Hepatitis Be antigen and infectivity of hepatitis B virus. J Infect Disease 136:571-576, 1977
3. Scotto J, Hadchouel M, Hery C, Yvart J, Tiollais P, Brechot C: Detection of hepatitis B virus DNA in serum by a simple spot hybridization technique: Comparison with results for other viral markers. Hepatology 3:279-284, 1983
4. Lieberman HM, LaBrecque DR, Kew MC, Hadziyannis SJ, Shafritz DA: Detection of hepatitis B virus DNA directly in human serum by a simplified molecular hybridization test: Comparison to HBeAg/anti-HBe status in HBsAg carriers. Hepatology 3:285-291, 1983
5. Matsuyama Y, Omata M, Yokosuka O, Imazeki F, Ito Y, Okuda K: Discordance of hepatitis B e antigen/antibody and hepatitis B virus deoxyribonucleic acid in serum. Analysis of 1063 specimens. Gastroenterology 89:1104-1108, 1985
6. Hadziyannis SJ, Lieberman HB, Karvountzis GG, Shafritz DA: Analysis of liver disease, nuclear HBcAg, viral replication and hepatitis B virus DNA in liver and serum of HBeAg vs anti-HBe positive carriers of hepatitis B virus. Hepatology 3:656-662, 1983
7. Kaneko S, Miller RH, Di Bisceglie AM, Feinstone SM, Hoofnagle JH, Purcell RH: Detection of hepatitis B virus DNA in serum by polymerase chain reaction. Gastroenterology 99:799-804, 1990
8. Yokosuka O, Omata M, Hosoda K, Tada M, Ehata T, Ohto M: Detection and direct sequencing of hepatitis B virus genome by DNA amplification method. Gastroenterology 100:175-181, 1991
9. Baker BL, Di Bisceglie AM, Kaneko S, Miller R, Feinstone SM, Waggoner JG, Hoofnagle JH: Determination of hepatitis B virus DNA in serum using the polymerase chain reaction: Clinical significance and correlation with serological markers. Hepatology 13:632-636, 1991
10. Carman WF, Jacyna MR, Hadziyannis S, Karayiannis P, McGarvey MJ, Makris A, Thomas HC: Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet 2:588-591, 1989
11. Akahane Y, Yamanaka T, Suzuki H, Sugai Y, Tsuda F, Yotsumoto S, Omi S, Okamoto H, Miyakawa Y, Mayumi M: Chronic active hepatitis with hepatitis B virus DNA and antibody againt e antigen in the serum. Gastroenterology 99:1113-1119, 1990
12. Brunetto MR, Giarin MM, Oliveri F, Chiaberge E, Baldi M, Alfarano A, Serra A, Sarcco G, Verme G, Will H, Bonino F: Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis. Proc Natl Acad Sci USA 88:4186-4190, 1991
13. Brunetto MR, Giarin M, Oliveri F, Saracco G, Barbera C, Parrella T, Abate ML: "e" antigen defective hepatitis B virus and course of chronic infection. J Hepatol 13:S82-S86, 1991
14. Naoumov NV, Schneider R, Groetzinger T, Jung MC, Miska S, Pape GR, Will H: Precore mutant hepatitis B virus infection and liver disease. Gastroenterology 102:538-543, 1992
15. Lai ME, Solinas A, Mazzoleni A, Deplano A, Farci P, Lisci V, Porru A, et al: The role of precore hepatitis B virus mutants on the long-term outcome of chronic hepatitis B virus hepatitis. A longitudinal study. J Hepatol 20:773-781, 1994
16. Ljunggren KK, Nordenfelt E, Kidd A: Correlation of HBeAg/anti-HBe, ALT levels, and HBV DNA PCR results in HBsAg-positive patients. J Med Virol 39:297-302, 1993
17. Peters M, Vierling J, Gershwin ME, Milich D, Chisari FV, Hoofnagle J: Immunology and the liver. Hepatology 13:977-994, 1991
18. Chisari FV, Ferrari C: Hepatitis B virus immunopathogenesis. Annu Rev Immunol 13:29-60, 1995
19. Bertoletti A, Chisari FV, Penna A, Guilhot S, Galati L, Missale G, Fowler P, Schlicht HJ, Vitiello A, Chesnut RC: Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein. J Virol 67:2376-2380, 1993
20. Milich DR, McLachlan A, Moriarty A, Thornton GB: Immune response to hepatitis B virus core antigen (HBcAg): Localization of T cell recognition sites within HBcAg/HBeAg. J Immunol 139:1223-1231, 1987
21. Ferrari C, Penna A, Giuberci T, Tong MJ, Ribera E, Fiaccadori F, Chisari FV: Intrahepatic nucleocapsid antigen specific T cell in chronic active hepatitis B. J Immunol 139:2050-2058, 1987
22. Ehata T, Omata T, Yokosuka O, Hosoda K, Ohto M: Variations in codon 84-101 in the core nucleotide sequence correlate with hepatocellular injury in chronic hepatitis B virus infection. J Clin Invest 89:332-338, 1992
23. Chuang W-L, Omata M, Ehata T, Yokosuka O, Ito Y, Imazeki F, Lu S-N, Chang W-Y, Ohto M: Precore mutations and core clustering mutations in chronic hepatitis B virus infection. Gastroenterology 104:263-271, 1993
24. + cytotoxic T lymphocytes. J Clin Invest 97:577-584, 1996
25. Lee P-I, Chang M-H, Lee C-Y, Hsu H-Y, Chen J-S, Chen P-J, Chen D-S: Changes of serum hepatitis B virus DNA and aminotransferase levels during the course of chronic hepatitis infection in children. Hepatology 12:657-660, 1990
26. Bortolotti F, Cadrobbi P, Crivellaro C, Guido M, Rugge M, Noventa F, Calzia R, Realdi G: Long-term outcome of chronic type B hepatitis in patients who acquire hepatitis B virus infection in childhood. Gastroenterology 99:805-810, 1990
27. De Franchis R, Mucci G, Vecchi M, Tatarella M, Colombo M, Ninno ED, Rumi MG, Donato MF, Ronchi G: Natural history of asymptomatic hepatitis B surface antigen carriers. Annals Int Med 118:191-194, 1993
28. Villeneuve J-P, Desrochers M, Infante-Rivard C, Willems B, Raymond G, Bourciere M, Cote J, Richer G: A long-term follow-up study of asymptomatic hepatitis B surface antigen-positive carriers in Montreal. Gastroenterology 106:1000-1005, 1994
29. Raimondo G, Meucci G, Sardo MA, Rodino G, Campo S, Vecchi M, Pernice M, Rumi MG, Tatarella M, De Franchis R: Persistence of "wild type" and "e-minus" hepatitis B virus infection in chronic healthy HBsAg/anti-HBe positive carriers. J Hepatol 20:148-151, 1994
30. Davis GL, Hoofnagle J: Reactivation of chronic type B hepatitis presenting as acute viral hepatitis. Ann Intern Med 102:762-765, 1985
31. Lok ASF, Liang RHS, Chiu EKW, Wong K-L, Chan T-K, Todd D: Reactivation of hepatitis B virus replication in patients receiving cytotoxic therapy. Gastroenterology 100:182-188, 1991
32. Yoshiba M, Sekiyama K, Sugata F, Okamoto H, Yamamoto K, Yotsumoto S: Reactivation of precore mutant hepatitis B virus leading to fulminant hepatic failure following cytotoxic treatment. Dig Dis Sci 37:1253-1259, 1992
33. Carman WF, McIntyre G, Hadziyannis S, Fattovich G, Alberti A, Thomas HC: Core protein evolution after selection of hepatitis B precore mutants and correlation with disease severity. In Viral Hepatitis and Liver Disease. K Nishioka, H Suzuki, S Mishiro, T Oda (eds). Tokyo, Springer-Verlag, 1944, pp 273-276
34. Kobayashi M, Koike K: Complete nucleotide sequence of hepatitis B virus DNA of subtype adr and its conserved gene organization. Gene 30:227-232, 1984
35. Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, Kiernan TW, Wollman J: Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1:431-435, 1981
36. Trevisian A, Gudet F, Busachi C, Stocklin E, Bianchi L: An improved method for HBcAg demonstration in paraffin-embedded liver tissue. Liver 2:331-339, 1982
37. Maruyama T, Iino S, Koike K, Yasuda K, Milich DR: Serology of acute exacerbation in chronic hepatitis B virus infection. Gastroenterology 105:1141-1151, 1993
38. Scaglioni PP, Melegari M, Wands JR: Characterization of hepatitis B virus core mutants that inhibit viral replication. Virology 205:112-120, 1994
39. Hatton T, Zhou S, Standring DN: RNA- and DNA-binding activities in hepatitis B virus capsid protein: A model for their roles in viral replication. J Virol 66:5232-5241, 1992
40. Tong S-P, Li J-S, Vitviski L, Trepo C: Replication capabilities of natural and artificial precore stop codon mutants of hepatitis B virus; relevance of pregenome encapsidation signal. Virology 191:237-245, 1992