Hormone replacement therapy use is associated with a lower occurrence of carotid atherosclerotic plaques but not with intima-media thickness progression among postmenopausal women. The vascular aging (EVA) study

Atherosclerosis

Volumn 166, Issue 1, 2003, Pages 163-170

  Le Gal, Grégoire ^a   Gourlet, Véronique ^a   Hogrel, Patricia ^a   Plu Bureau, Geneviève ^a   Touboul, Pierre Jean ^b   Scarabin, Pierre Yves ^a  

^a INSERM   (France)

^b Ctr Diagn et de Prev Neurovasc   (France)

Author keywords

Arteriosclerosis; Atherosclerotic plaques; Carotid artery disease; Hormone replacement therapy; Intima media thickness; Longitudinal study

Indexed keywords

ESTROGEN; GESTAGEN;

ADULT; AGED; AGING; ARTICLE; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR RISK; CAROTID ARTERY; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; ECHOGRAPHY; FEMALE; HORMONE SUBSTITUTION; HUMAN; INTIMA; MAJOR CLINICAL STUDY; POSTMENOPAUSE; PRIORITY JOURNAL; TREATMENT OUTCOME; ARTERIOSCLEROSIS; BODY MASS; CAROTID ARTERY DISEASE; COMMON CAROTID ARTERY; DISEASE COURSE; ESTROGEN THERAPY; INTRADERMAL DRUG ADMINISTRATION; MIDDLE AGED; PATHOLOGY; TUNICA MEDIA;

ADMINISTRATION, CUTANEOUS; AGED; ARTERIOSCLEROSIS; BODY MASS INDEX; CAROTID ARTERY DISEASES; CAROTID ARTERY, COMMON; DISEASE PROGRESSION; ESTROGEN REPLACEMENT THERAPY; FEMALE; HUMANS; MIDDLE AGED; POSTMENOPAUSE; TUNICA INTIMA; TUNICA MEDIA;

EID: 0037211993     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(02)00325-8     Document Type: Article

References (46)

1. Barrett-Connor E., Grady D. Hormone replacement therapy, heart disease, and other considerations. Annu. Rev. Public Health. 19:1998;55-72.
2. Gruchow H.W., Anderson A.J., Barboriak J.J., Sobocinski K.A. Postmenopausal use of estrogen and occlusion of coronary arteries. Am. Heart J. 115:(5):1988;954-963.
3. Sullivan J.M., Vander Zwaag R., Lemp G.F., Hughes J.P., Maddock V., Kroetz F.W., et al. Postmenopausal estrogen use and coronary atherosclerosis. Ann. Intern. Med. 108:(3):1988;358-363.
4. McFarland K.F., Boniface M.E., Hornung C.A., Earnhardt W., Humphries J.O. Risk factors and noncontraceptive estrogen use in women with and without coronary disease. Am. Heart J. 117:(6):1989;1209-1214.
5. van Baal W.M., Kooistra T., Stehouwer C.D. Cardiovascular disease risk and hormone replacement therapy (HRT): a review based on randomised, controlled studies in postmenopausal women. Curr. Med. Chem. 7:(5):2000;499-517.
6. Mendelsohn M.E., Karas R.H. The protective effects of estrogen on the cardiovascular system. N. Engl. J. Med. 340:(23):1999;1801-1811.
7. Bonithon-Kopp C., Scarabin P.Y., Taquet A., Touboul P.J., Malmejac A., Guize L. Risk factors for early carotid atherosclerosis in middle-aged French women. Arterioscler. Thromb. 11:(4):1991;966-972.
8. Heiss G., Sharrett A.R., Barnes R., Chambless L.E., Szklo M., Alzola C. Carotid atherosclerosis measured by B-mode ultrasound in populations: associations with cardiovascular risk factors in the ARIC study. Am. J. Epidemiol. 134:(3):1991;250-256.
9. Bots M.L., Hoes A.W., Hofman A., Witteman J.C., Grobbee D.E. Cross-sectionally assessed carotid intima-media thickness relates to long-term risk of stroke, coronary heart disease and death as estimated by available risk functions. J. Intern. Med. 245:(3):1999;269-276.
10. Salonen J.T., Salonen R. Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. Arterioscler. Thromb. 11:(5):1991;1245-1249.
11. Griewing B., Romer T., Spitzer C., Ludemann J., Gunther A., Kessler C. Hormone replacement therapy in postmenopausal women: carotid intima-media thickness and 3-D volumetric plaque quantification. Maturitas. 32:(1):1999;33-40.
12. Espeland M.A., Applegate W., Furberg C.D., Lefkowitz D., Rice L., Hunninghake D. Estrogen replacement therapy and progression of intimal-medial thickness in the carotid arteries of postmenopausal women. ACAPS investigators. Asymptomatic Carotid Atherosclerosis Progression Study. Am. J. Epidemiol. 142:(10):1995;1011-1019.
13. de Kleijn M.J., Bots M.L., Bak A.A., Westendorp I.C., Planellas J., Coelingh Bennink H.J., et al. Hormone replacement therapy in perimenopausal women and a 2-year change of carotid intima-media thickness. Maturitas. 32:(3):1999;195-204.
14. Angerer P., Stork S., Kothny W., Schmitt P., von Schacky C.C. Effect of oral postmenopausal hormone replacement on progression of atherosclerosis: a randomized, controlled trial. Arterioscler. Thromb. Vasc. Biol. 21:(2):2001;262-268.
15. Hodis H.N., Mack W.J., Lobo R.A., Shoupe D., Sevanian A., Mahrer P.R., et al. Estrogen in the prevention of atherosclerosis. A randomized, double-blind, placebo-controlled trial. Ann. Intern. Med. 135:(11):2001;939-953.
16. Bonithon-Kopp C., Touboul P.J., Berr C., Leroux C., Mainard F., Couborn D., et al. Relation of intima-media thickness to atherosclerotic plaques in carotid arteries. The Vascular Aging (EVA) Study. Arterioscler. Thromb. Vasc. Biol. 16:(2):1996;310-316.
17. Touboul P.J., Prati P., Scarabin P.Y., Adrai V., Thibout E., Ducimetiere P. Use of monitoring software to improve the measurement of carotid wall thickness by B-mode imaging. J. Hypertens. 10:(Suppl 5):1992;S37-S41.
18. Pignoli P., Tremoli E., Poli A., Oreste P., Paoletti R. Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. Circulation. 74:(6):1986;1399-1406.
19. Zureik M., Touboul P.J., Bonithon-Kopp C., Courbon D., Berr C., Leroux C., et al. Cross-sectional and 4-year longitudinal associations between brachial pulse pressure and common carotid intima-media thickness in a general population. The EVA study. Stroke. 30:(3):1999;550-555.
20. Matthews K.A., Kuller L.H., Wing R.R., Meilahn E.N., Plantinga P. Prior to use of estrogen replacement therapy, are users healthier than nonusers? Am. J. Epidemiol. 143:(10):1996;971-978.
21. The Coronary Drug Project. Initial findings leading to modifications of its research protocol. JAMA 1970;214(7):1303-13.
22. Zureik M., Ducimetiere P., Touboul P.J., Courbon D., Bonithon-Kopp C., Berr C., et al. Common carotid intima-media thickness predicts occurrence of carotid atherosclerotic plaques: longitudinal results from the Aging Vascular Study (EVA) study. Arterioscler. Thromb. Vasc. Biol. 20:(6):2000;1622-1629.
23. Bots M.L., Witteman J.C., Grobbee D.E. Carotid intima-media wall thickness in elderly women with and without atherosclerosis of the abdominal aorta. Atherosclerosis. 102:(1):1993;99-105.
24. Allan P.L., Mowbray P.I., Lee A.J., Fowkes F.G. Relationship between carotid intima-media thickness and symptomatic and asymptomatic peripheral arterial disease. The Edinburgh Artery Study. Stroke. 28:(2):1997;348-353.
25. Boutouyrie P., Bussy C., Hayoz D., Hengstler J., Dartois N., Laloux B., et al. Local pulse pressure and regression of arterial wall hypertrophy during long-term antihypertensive treatment. Circulation. 101:(22):2000;2601-2606.
26. Furberg C.D., Adams H.P., Applegate W.B., Byington R.P., Espeland M.A., Hartwell T., et al. Effect of lovastatin on early carotid atherosclerosis and cardiovascular events. Asymptomatic Carotid Artery Progression Study (ACAPS) Research Group. Circulation. 90:(4):1994;1679-1687.
27. Blankenhorn D.H., Selzer R.H., Crawford D.W., Barth J.D., Liu C.H., et al. Beneficial effects of colestipol-niacin therapy on the common carotid artery. Two- and four-year reduction of intima-media thickness measured by ultrasound. Circulation. 88:(1):1993;20-28.
28. Homma S., Hirose N., Ishida H., Ishii T., Araki G. Carotid plaque and intima-media thickness assessed by b-mode ultrasonography in subjects ranging from young adults to centenarians. Stroke. 32:(4):2001;830-835.
29. Bots M.L., Hofman A., Grobbee D.E. Increased common carotid intima-media thickness. Adaptive response or a reflection of atherosclerosis? Findings from the Rotterdam Study. Stroke. 28:(12):1997;2442-2447.
30. Dubuisson J.T., Wagenknecht L.E., D'Agostino R.B., Haffner S.M., Rewers M., Saad M.F., et al. Association of hormone replacement therapy and carotid wall thickness in women with and without diabetes. Diabetes Care. 21:(11):1998;1790-1796.
31. Jonas H.A., Kronmal R.A., Psaty B.M., Manolio T.A., Meilahn E.N., Tell G.S., et al. Current estrogen-progestin and estrogen replacement therapy in elderly women: association with carotid atherosclerosis. CHS Collaborative Research Group. Cardiovascular Health Study. Ann. Epidemiol. 6:(4):1996;314-323.
32. Manolio T.A., Furberg C.D., Shemanski L., Psaty B.M., O'Leary D.H., Tracy R.P., et al. Associations of postmenopausal estrogen use with cardiovascular disease and its risk factors in older women. The CHS Collaborative Research Group. Circulation. 88:(5 Pt. 1):1993;2163-2171.
33. McGrath B.P., Liang Y.L., Teede H., Shiel L.M., Cameron J.D., Dart A. Age-related deterioration in arterial structure and function in postmenopausal women: impact of hormone replacement therapy. Arterioscler. Thromb. Vasc. Biol. 18:(7):1998;1149-1156.
34. Nabulsi A.A., Folsom A.R., Szklo M., White A., Higgins M., Heiss G. No association of menopause and hormone replacement therapy with carotid artery intima-media thickness. Atherosclerosis Risk in Communities (ARIC) Study Investigators. Circulation. 94:(8):1996;1857-1863.
35. Westendorp I.C., Veld B.A., Bots M.L., Akkerhuis J.M., Hofman A., Grobbee D.E., et al. Hormone replacement therapy and intima-media thickness of the common carotid artery: the Rotterdam study. Stroke. 30:(12):1999;2562-2567.
36. Adams M.R., Kaplan J.R., Manuck S.B., Koritnik D.R., Parks J.S., Wolfe M.S., et al. Inhibition of coronary artery atherosclerosis by 17-beta estradiol in ovariectomized monkeys. Lack of an effect of added progesterone. Arteriosclerosis. 10:(6):1990;1051-1057.
37. Adams M.R., Register T.C., Golden D.L., Wagner J.D., Williams J.K. Medroxyprogesterone acetate antagonizes inhibitory effects of conjugated equine estrogens on coronary artery atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 17:(1):1997;217-221.
38. Herrington D.M., Reboussin D.M., Brosnihan K.B., Sharp P.C., Shumaker S.A., Snyder T.E., et al. Effects of estrogen replacement on the progression of coronary-artery atherosclerosis. N. Engl. J. Med. 343:(8):2000;522-529.
39. Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. The Writing Group for the PEPI Trial. JAMA 1995;273(3):199-208.
40. Taskinen M.R., Puolakka J., Pyorala T., Luotola H., Bjaorn M., Kaarianen J., et al. Hormone replacement therapy lowers plasma Lp(a) concentrations. Comparison of cyclic transdermal and continuous estrogen-progestin regimens. Arterioscler. Thromb. Vasc. Biol. 16:(10):1996;1215-1221.
41. Sack M.N., Rader D.J., Cannon R.O. Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women. Lancet. 343:(8892):1994;269-270.
42. Scarabin P.Y., Alhenc-Gelas M., Oger E., Plu-Bureau G. Hormone replacement therapy and circulating ICAM-1 in postmenopausal women - a randomised controlled trial. Thromb. Haemost. 81:(5):1999;673-675.
43. Vehkavaara S., Hakala-Ala-Pietila T., Virkamaki A., Bergholm R., Ehnholm C., Hovatta O., et al. Differential effects of oral and transdermal estrogen replacement therapy on endothelial function in postmenopausal women. Circulation. 102:(22):2000;2687-2693.
44. Scarabin P.Y., Alhenc-Gelas M., Plu-Bureau G., Taisne P., Agher R., Aiach M. Effects of oral and transdermal estrogen/progesterone regimens on blood coagulation and fibrinolysis in postmenopausal women. A randomized controlled trial. Arterioscler. Thromb. Vasc. Biol. 17:(11):1997;3071-3078.
45. Vehkavaara S., Silveira A., Hakala-Ala-Pietila T., Virkamaki A., Hovatta O., Hamsten A., et al. Effects of oral and transdermal estrogen replacement therapy on markers of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women. Thromb. Haemost. 85:(4):2001;619-625.
46. Vongpatanasin W., Tuncel M., Mansour Y., Arbique D., Victor R.G. Transdermal estrogen replacement therapy decreases sympathetic activity in postmenopausal women. Circulation. 103:(24):2001;2903-2908.