Effects of chlorinated aliphatic hydrocarbons on the fidelity of cell division in human CYP2E1 expressing cells

Experimental and Molecular Medicine

Volumn 34, Issue 1, 2002, Pages 83-89

  Kim, Adele ^a   Parry, Elizabeth M ^a   Parry, James M ^a  

^a Samsung Medical Center   (South Korea)

Author keywords

Chlorinated; Chromosome aberrations; Cytochrome P 450 CYP2E1; Hydrocarbons; Mitotic spindle apparatus

Indexed keywords

1,1,2 TRICHLOROETHANE; 1,2 DICHLOROETHANE; BUTANE; CHLORINATED HYDROCARBON; CYTOCHROME P450 2E1; HEXANE; TRICHLOROETHYLENE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIVISION; CHINESE HAMSTER; CHROMOSOME ABERRATION; HUMAN; HUMAN CELL; MITOSIS SPINDLE; NONHUMAN; ANIMAL; CELL LINE; CHEMISTRY; CHROMOSOME; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; HAMSTER; METABOLISM; METHODOLOGY; STAINING;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; MAMMALIA;

ANIMALS; CELL DIVISION; CELL LINE; CHROMOSOMES; CRICETINAE; CYTOCHROME P-450 CYP2E1; ENZYME ACTIVATION; HUMANS; HYDROCARBONS, CHLORINATED; MITOTIC SPINDLE APPARATUS; STAINING AND LABELING;

EID: 0037204433     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2002.12     Document Type: Article

References (23)

1. Xklp2, a novel Xenopus centrosomal kinesin-like protein required for centrosome separation during mitosis
2. Germinal vesicle breakdown in the mouse oocyte
3. Induction of chromosome malsegregation by halogenated organic solvents in Aspergillus nidulans: Unspecific or specific mechanism?
4. An investigation into the activation and deactivation of chlorinated hydrocarbons to genotoxins in metabolically competent human cells
5. Species differences in carcinogenicity and peroxisome proliferation due to trichloroethylene: A biochemical human hazard assessment
6. Direct aqueous injection gas chromatography-mass spectrometry for analysis of organohalides in water at concentrations below the parts per billion level
7. Abnormal centrosome amplification in the absence of p53
8. Alteration of chloral hydrate metabolism in rats with carbon tetrachloride-induced liver-damage
9. Multiple mechanisms in the regulation of ethanol-inducible cytochrome-P45011E1
10. Biochemical and molecular-basis of alcohol-induced injury to liver and other tissues
11. Oxidation of trichloroethylene by liver microsomal cytochrome P-450: Evidence for chlorine migration in a transition state not involving trichloroethylene oxide
12. Differential staining of chromosome and spindle and its use as an assay for determining the effect of diethylstilboestrol on cultured mammalian cells
13. The anaphase movement of chromosomes in the spermatocytes of the grasshopper
14. Cytochrome-P-450 CYP2E1 induction during chronic alcohol exposure occurs by a 2-step mechanism associated with blood-alcohol concentrations in rats
15. Gamma tubulin is a highly conserved component of the centrosome
16. Dose dependent effect of resveratrol on proliferation and apoptosis in endothelial and tumor cell cultures
17. Monastral bipolar spindles: Implications for dynamic centrosome organization
18. A differential staining technique for simultaneous visualization of mitotic spindle and chromosomes in mammalian cells
19. Chromosomes lacking kinetochore proteins their meta-anaphase location suggests potential malsegregation
20. Metabolism of N-nitrosodialkylamines by human liver microsomes
21. The impact of chromosomes and centrosomes on spindle assembly as observed in living cells