D4-GDI is cleaved by caspase-3 during daunorubicin-induced apoptosis in HL-60 cells

Experimental and Molecular Medicine

Volumn 34, Issue 1, 2002, Pages 32-37

  Kwon, Kang Beom ^a   Park, Eun Kyung ^a   Ryu, Do Gon ^a   Park, Byung Hyun ^a  

^a Chonbuk National University   (South Korea)

Author keywords

Apoptosis; Caspase 3; D4 GDI; Daunorubicin; Poly(ADP ribose) polymerase

Indexed keywords

CASPASE 3; CASPASE INHIBITOR; DAUNORUBICIN; DNA FRAGMENT; GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR; GUANOSINE TRIPHOSPHATASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; RAS PROTEIN; RHO FACTOR; ACETYL ASPARTYL GLUTAMYL VALYL ASPARTAL; ACETYL-ASPARTYL-GLUTAMYL-VALYL-ASPARTAL; ANTINEOPLASTIC AGENT; CASP3 PROTEIN, HUMAN; CASPASE; CYSTEINE PROTEINASE INHIBITOR; OLIGOPEPTIDE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS;

APOPTOSIS; ARTICLE; DOSE RESPONSE; ENZYME ACTIVITY; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; CELL STRAIN HL 60; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; METABOLISM; PHYSIOLOGY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASES; CYSTEINE PROTEINASE INHIBITORS; DAUNORUBICIN; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS; HL-60 CELLS; HUMANS; OLIGOPEPTIDES; RHO GTP-BINDING PROTEINS;

EID: 0037204426     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2002.5     Document Type: Article

References (42)

1. Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1
2. Emerging concepts in the Ras superfamily of GTP-binding proteins
3. Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
4. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
5. Caspases: The executioners of apoptosis
6. The small GTP-binding proteins Racl and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
7. Defective Rho GTPase regulation by IL-1 beta-converting enzyme-mediated cleavage of D4 GDP dissociation inhibitor
8. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
9. GDP dissociation inhibitor D4-GDI (Rho-GDI 2), but not the homologous rho-GDI 1, is cleaved by caspase-3 during drug-induced apoptosis
10. Doxorubicin-induced apoptosis in human T-cell leukemia is mediated by caspase-3 activation in a Fas-independent way
11. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
12. GEFs, GAPs, GDIs and effectors: Taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins
13. Targeted disruption of guanosine diphosphate-dissociation inhibitor for Rho-related proteins, GDID4: Normal hematopoietic differentiation but subtle defect in superoxide production by macrophages derived from in vitro embryonal stem cell differentiation
14. Daunorubicin-induced apoptosis: Triggering of ceramide generation through sphingomyelin hydrolysis
15. TNF-alpha-mediated neutrophil apoptosis involves Ly-GDI, a Rho GTPase regulator
16. Induction of apoptosis in human leukemia cells by 3-deazaadenosine is mediated by caspase-3-like activity
17. Caspase-3-generated fragment of gelsolin: Effector of morphological change in apoptosis
18. Cleavage and nuclear translocation of the caspase 3 substrate Rho GDP-dissociation inhibitor, D4-GDI, during apoptosis
19. Vibrio vulnificus cytolysin induces superoxide anion-initiated apoptotic signaling pathway in human ECV304 cells
20. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
21. cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins
22. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
23. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
24. D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis
25. Apoptosis by death factor
26. The small GTPase Rho: Cellular functions and signal transduction
27. Caspases: Killer proteases
28. Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase
29. A quantitative colorimetric method to evaluate the functional state of human polymorphonuclear leukocytes
30. Rho guanine dissociation inhibitors: Pivotal molecules in cellular signalling
31. Selective activation of caspases during apoptotic induction in HL-60 cells. Effects Of a tetrapeptide inhibitor
32. Lamin proteolysis facilitates nuclear events during apoptosis
33. Inhibition of CPP32 blocks surface IgM-mediated apoptosis and D4-GDI cleavage in human BL60 Burkitt lymphoma cells
34. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
35. The Rho small G protein family-Rho GDI system as a temporal and spatial determinant for cytoskeletal control
36. Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes
37. Necessity of interleukin-1beta converting enzyme cascade in taxotere-initiated death signaling
38. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
39. Caspase-3-like activity is necessary but not sufficient for daunorubicin-induced apoptosis in Jurkat human lymphoblastic leukemia cells
40. BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases
41. Immune responses in mice deficient in Ly-GDI, a lymphoid-specific regulator of Rho GTPases
42. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1