Effect of (-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans- 4-(3-hydroxypropyl) cyclohexanol (CP55,940) on intracellular Ca 2+ levels in human osteosarcoma cells

Chinese Journal of Physiology

Volumn 45, Issue 3, 2002, Pages 95-100

  Lu, Yin Chau ^a   Su, Warren ^a   Jiann, Bang Ping ^a   Chang, Hong Tai ^a   Huang, Jong Khing ^a   Jan, Chung Ren ^a  

^a KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

CP55,940; MG63 cells; Osteoblast; Thapsigargin

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N MORPHOLINO 1H PYRAZOLE 3 CARBOXAMIDE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 2,5 PYRROLIDINEDIONE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; DILTIAZEM; FLUORESCENT DYE; FURA 2; INDICATOR; MANGANESE; NIFEDIPINE; PHOSPHOLIPASE C; THAPSIGARGIN; TRYPAN BLUE; VERAPAMIL; CALCIUM; CYCLOHEXANOL DERIVATIVE; ENZYME INHIBITOR; IMMUNOSUPPRESSIVE AGENT;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL ASSAY; CELL DEATH; CELL MEMBRANE; CELL SUSPENSION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENDOPLASMIC RETICULUM; EPITHELIUM CELL; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; INCUBATION TIME; OSTEOBLAST; OSTEOSARCOMA CELL; SENSITIVITY ANALYSIS; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; METABOLISM; OSTEOSARCOMA;

CALCIUM; CYCLOHEXANOLS; ENZYME INHIBITORS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; OSTEOBLASTS; OSTEOSARCOMA; PHOSPHOLIPASE C; THAPSIGARGIN; TUMOR CELLS, CULTURED;

EID: 0037201070     PISSN: 03044920     EISSN: 26660059     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Al-Hayani, A. and Davies, S.N. Cannabinoid receptor mediated inhibition of excitatory synaptic transmission in the rat hippocampal slice is developmentally regulated. Br. J. Pharmacol. 131: 663-665, 2000.
2. Berridge, M.J. Inositol trisphosphate and calcium signaling. Nature. 361: 315-325, 1993.
3. Berridge, M.J. Elementary and global aspects of calcium signaling. J. Physiol. 499: 291-306, 1997.
4. 2+ entry (CCE): interaction between IP3 receptor and TRP links the internal calcium storage compartment to plasma membrane CCE channels. Recent. Prog. Horm. Res. 55: 127-161, 2000.
5. Bootman, M.D., Berridge, M.J., and Lipp, P. Cooking with calcium: the recipes for composing global signals from elementary events. Cell. 91: 367-373, 1997.
6. Breivogel, C.S., Griffin, G., Di Marzo, V., and Martin, B.R. Evidence for a new G protein-coupled cannabinoid receptor in mouse brain. Mol. Pharmacol. 60: 155-163, 2001s.
7. Chen, Y.C., Chen, S.J., Chang, H.T., Huang, J.K., Wang, J.L., Tseng, L.L., Chang, H.J., Su, W., Law, Y.P., Chen, W.C., and Jan, C.R. Mechanisms of diethylstilbestrol-induced calcium movement in MG63 human osteosarcoma. cells. Toxicol. Lett. 122: 245-253, 2001a.
8. i increases in human osteoblast-like cells. Chin. J. Physiol. 44: 67-72, 2001b.
9. 2+ levels in hepatoma cells. Chin. J. Physiol. 43: 165-169, 2000.
10. i , increases in MDCK renal tubular cells. Chin. J. Physiol. 44: 97-101 2001a.
11. 2+ levels in Madin-Darby canine kidney cells. Life. Sci. 69: 1541-1548 2001b.
12. Esposito, G., Izzo, A.A., Di Rosa, M., and Iuvone, T. Selective cannabinoid CB1 receptor-mediated inhibition of inducible nitric oxide synthase protein expression in C6 rat glioma cells. J. Neurochem. 78: 835-841 2001.
13. Grynkiewicz, G., Poenie, M., amd Tsien, R.Y. A new generation of Ca indicators with greatly improved fluorescence properties. J. Biol. Chem. 260: 3440-3450, 1985.
14. Hajos, N., Katona, I., Naiem, S.S., MacKie, K., Ledent, C., Mody, I., and Freund, T.F. Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations. Eur. J. Neurosci. 12: 3239-3249, 2000.
15. 2+ mobilization induced by W-7 in MG63 human osteosarcoma cells. Pharmacol. Res. 42: 323-327, 2000.
16. 2+ entry in MG63 human osteosarcoma cells. Biochem. Pharmacol. 61: 1537-1541, 2001.
17. Little, P.J., Compton, DR., Johnson, M.R., and Martin, L.S. Pharmacology and stereoselectivity of structurally novel cannabinoids in mice. J. Pharmacol. Exp. Ther. 247: 1046-1051, 1988.
18. 2+ movement in A10 smooth muscle cells. Chin. J. Physiol. 44: 19-24, 2001.
19. Mang, C.F., Erbelding, D., and Kilbinger, H. Differential effects of anandamide on acetylcholine release in the guinea-pig ileum mediated via vanilloid and non-CB(1) cannabinoid receptors. Br. J. Pharmacol. 134: 161-167, 2001.
20. Merritt, J.E., Jocob, R., and Hallam, T.J. Use of manganese to discriminate between calcium influx and mobilization from internal stores in stimulated human neutrophils. J. Biol. Chem. 264: 1522-1527, 1989.
21. Niederhoffer, N. and Szabo, B. Effect of the cannabinoid receptor agonist WIN55212-2 on sympathetic cardiovascular regulation. Br. J. Pharmacol. 126: 457-466, 1999.
22. Putney, JW. Jr. A model for receptor-regulated calcium entry. Cell. Calcium.7: 1-12, 1986.