Selective cannabinoid CB1 receptor-mediated inhibition of inducible nitric oxide synthase protein expression in C6 rat glioma cells

Journal of Neurochemistry

Volumn 78, Issue 4, 2001, Pages 835-841

  Esposito, Giuseppe ^a   Izzo, Angelo A ^a   Di Rosa, Massimo ^a   Iuvone, Teresa ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

C6 glioma cells; Cannabinoid receptors; Cannabinol; iNOS protein expression; Nitric oxide; WIN 55,212 2

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; CANNABINOL; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; RIMONABANT;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; GENETIC TRANSCRIPTION; GLIOMA CELL; INFLAMMATION; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT;

ANALGESICS; ANIMALS; ASTROCYTES; BLOTTING, WESTERN; CANNABINOL; CELL FRACTIONATION; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNOBLOTTING; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; MORPHOLINES; NAPHTHALENES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; RATS; RECEPTOR, CANNABINOID, CB2; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; TUMOR CELLS, CULTURED;

EID: 0034888225     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00465.x     Document Type: Article

References (51)

1. Tetrahydrocannabinol treatment suppresses growth restriction of Legionella pneumophila in murine macrophage cultures
2. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-α gene expression in endotoxin-stiomulated primary glial cultures
3. Nitric oxide-mediated mitochondrial damage in the brain - Mechanisms and implications for neurodegenerative diseases
4. 1
5. Novel approaches to the symptomatic treatment of Parkinsonian syndromes: Alternatives and adjuncts to dopamine-replacement
6. Tetrahydrocannabinol inhibition of macrophage nitric oxide production
7. 9-tetrahydrocannabinol
8. Gases as biological messengers: Nitric oxide and carbon monoxide in the brain
9. Nitric oxide in neuronal degeneration
10. Endocannabinoids: New target for drug developement
11. Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages
12. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors
13. Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures
14. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulation
15. Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
16. Glutamate, nitric oxide and cell-cell signalling in the nervous system
17. Marijuana as medicine a plea for consideration
18. 9-tetrahydrocannabinol is mediated through the inhibition of nuclear factor-κB/Rel activation
19. Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism
20. Formation of nitric oxide from L-arginine in the central nervous system: A transduction mechanismfor the stimulation of of the soluble guanylate cyclase
21. Microglia: A sensor for pathological events in tha CNS
22. Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1β
23. Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus
24. Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells
25. Relative involvement of cannabinoid CB1 and CB2 receptors in the Δ9-tetrahydrocannabinol-induced inhibition of natural killer activity
26. Structure of a cannabinoid receptor and functional expression of the cloned cDNA
27. Prolactin induction of nitric oxide synthase in rat C6 glioma cells
28. E. coli lipopolysaccharide enances the release of a NO-like factor from astrocytoma cells in culture
29. Nitric oxide: Physiology, pathophysiology and pharmacology
30. Astrocytes in infectious and immune-mediated diseases of the central nervous system
31. Molecular characterization of a peripheral receptor for cannabinoids
32. Role of protein kinase A in LPS-induced activation of NF-kappa B proteins of a mouse macrophage-like cell line J774
33. Evidence for an astrocyte-derived vasorelaxing factor with properties similar to nitric oxide
34. Synthesis of nitric oxide in CNS glial cells
35. Involvement of nuclear factor-κB (NF-κB) signaling in the expression of inducible nitric oxide synthase (iNOS) gene in rat C6 glioma cells
36. Protein kinase C in tumoricidal activation of mouse macrophage cell lines
37. Pharmacology of cannabinoid CB1 and CB2 receptors
38. 9-tetrahydrocannabinol and antagonist activity of cannabidiol on rat brain cannabinoid receptors
39. The endocannabinoid system as a target for therapeutic drugs
40. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
41. 2 cannabinoid receptor
42. Inhibition of nitric oxide production in RAW 264.7 macrophages by cannabinoids and palmitoylethanolamide
43. Time course of lipopolysaccaride - Induced nitric oxide synthase mRNA expression in rat glomeruli
44. Widespread tissue distribution, species distribution and changes in activity of Ca(2+)-dependent and Ca(2+)-independent nitric oxide synthases
45. Induction of nitric oxide in glial cells
46. The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of exocitotoxic death in cerebellar granule neurons
47. Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin-10 in endotoxemic mice
48. Medicinal applications of delta-9-tetrahydrocannabinol and marijuana
49. The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells
50. The NF-κB/Rel and IκB gene families: Mediators of immune response and inflammation