2′,5′-Dihydroxychalcone down-regulates endothelial connexin43 gap junctions and affects MAP kinase activation

Toxicology

Volumn 179, Issue 1-2, 2002, Pages 51-60

  Lee, Yi Nan ^a   Yeh, Hung I ^a   Tian, Tin Yi ^a   Lu, Wen Wei ^a   Ko, Yu Shien ^b   Tsai, Cheng Ho ^a  

^a MACKAY MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

2 ,5 Dihydroxychalcone; Connexin43; Endothelial cells; Gap junction; MAP kinase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2',5' DIHYDROXYCHALCONE; CHALCONE DERIVATIVE; CONNEXIN 43; GAP JUNCTION PROTEIN; LEUPEPTIN; MITOGEN ACTIVATED PROTEIN KINASE; N ACETYLLEUCYLLEUCYLNORLEUCINAL; UNCLASSIFIED DRUG; 2',5'-DIHYDROXYCHALCONE; CHALCONE; DRUG DERIVATIVE; ENZYME INHIBITOR; FLAVONOID; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEINASE INHIBITOR; VON WILLEBRAND FACTOR;

ARTICLE; BLEACHING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FETAL CALF SERUM; FLUORESCENCE; GAP JUNCTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; UMBILICAL VEIN; BIOSYNTHESIS; CELL COMMUNICATION; CELL CULTURE; CELL JUNCTION; DRUG ANTAGONISM; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; METABOLISM; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL COMMUNICATION; CELLS, CULTURED; CHALCONE; CHALCONES; CONNEXIN 43; CYCLOOXYGENASE INHIBITORS; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVONOIDS; FLUORESCENT ANTIBODY TECHNIQUE; GAP JUNCTIONS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEASE INHIBITORS; VON WILLEBRAND FACTOR;

EID: 0037200730     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00289-5     Document Type: Article

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