Enhanced cholinergic activity in the medulla oblongata of DOCA-Salt hypertensive and renal hypertensive rats

Hypertension Research - Clinical and Experimental

Volumn 19, Issue 3, 1996, Pages 213-219

  Kubo, Takao ^a   Fukumori, Ryuji ^a   Kobayashi, Midori ^a   Yamaguchi, Hiroaki ^a  

^a SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Choline acetyltransferase; DOCA salt hypertension; Medulla oblongata; Plasma catecholamines; Renal hypertension

Indexed keywords

ADRENALIN; CATECHOLAMINE; CHOLINE ACETYLTRANSFERASE; DEOXYCORTICOSTERONE ACETATE; NORADRENALIN; PHYSOSTIGMINE;

ADRENALIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CATECHOLAMINE BLOOD LEVEL; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; DISEASE COURSE; HYPERTENSION; MALE; MEDULLA OBLONGATA; NONHUMAN; NORADRENALIN BLOOD LEVEL; PRESSOR RESPONSE; RAT; RENOVASCULAR HYPERTENSION; SYSTOLIC BLOOD PRESSURE;

EID: 0029985138     PISSN: 09169636     EISSN: None     Source Type: Journal    
DOI: 10.1291/hypres.19.213     Document Type: Article

References (31)

1. Brezenoff HE, Giuliano R: Cardiovascular control by cholinergic mechanisms in the central nervous system. Annu Rev Pharmacol Toxicol 1982; 22: 341-381.
2. Buccafusco JJ, Spector S: Role of central cholinergic neurons in experimental hypertension. J Cardiovasc Pharmacol 1980; 2: 347-355.
3. Kubo T, Tatsumi M: Increased pressor response to physostigmine in spontaneously hypertensive rats. Naunyn Schmiedebergs Arch Pharmacol 1979; 306: 81-83.
4. Makari NF, Trimachi GR, Buccafusco JJ: Contribution of pre- and post-synaptic components to heightened central cholinergic activity in spontaneously hypertensive rats. Neuropharmacology 1989; 28: 379-386.
5. Brezenoff HE, Caputi AP: Intracerebroventricular injection of hemicholimium-3 lowers blood pressure in conscious spontaneously hypertesive rats but not in normotensive rats. Life Sci 1980; 26: 1037-1045.
6. Giuliano R, Brezenoff HE: Increased central cholinergic activity in rat models of hypertension. J Cardiovasc Pharmacol 1987; 10: 113-122.
7. Dampney RAL, Goodchild AK, Robertson LG, Montogomery W: Role of ventrolateral medulla in vasomotor regulation: a correlative anatomical and physiological study. Brain Res 1982; 249: 223-235.
8. Kubo T, Nagura J, Kihara M, Misu Y: Cardiovascular effects of L-glutamate and γ-aminobutyric acid injected into the rostral ventrolateral medulla in normotensive and spontaneously hypertensive rats. Arch Int Pharmacodyn Ther 1986; 279: 150-161.
9. Ross CA, Ruggiero DA, Park DH, et al: Tonic vasomotor control by the rostral ventrolateral medulla: effect of electrical or chemical stimulation of the area containing C1 adrenaline neurons on arterial pressure, heart rate, and plasma catecholamines and vasopressin. J Neurosci 1984; 4: 474-494.
10. Willette RN, Barcas PP, Krieger AJ, Sapru HN: Vasopressor and depressor areas in the rat medulla: identification by microinjection of L-glutamate. Neuropharmacology 1983; 22: 1071-1079.
11. Amendt K, Czachurski J, Dembowsky K, Seller H: Bulbospinal projections to the intermediolateral cell column; a neuroanatomical study. J Auton Nerv Syst 1979; 1: 103-117.
12. Brown DL, Guyenet PG: Cardiovascular neurons of brainstem with projections to spinal cord. Am J Physiol 1984; 247: R1009-R1016.
13. Caverson MM, Ciriello J, Calaresu FR: Cardiovascular afferent inputs to neurons in the ventrolateral medulla projecting directly to the central autonomic area of the thoracic cord in the cat. Brain Res 1983; 247: 354-358.
14. Arneric SP, Giuliano R, Ernsberger P, Underwood MD, Reis DJ: Synthesis, release and receptor binding of acetylcholine in the C1 area of the rostral ventrolateral medulla: contributions in regulating arterial pressure. Brain Res 1990; 511: 98-112.
15. Ernsberger P, Arango V, Reis DJ: A high density of muscarinic receptors in the rostral ventrolateral medulla of the rat is revealed by correction for autoradiographic efficiency. Neurosci Lett 1988; 85: 179-186.
16. Giuliano R, Ruggiero DA, Morrison S, Ernsberger P, Reis DJ: Cholinergic regulation of arterial pressure by the C1 area of the rostral ventrolateral medulla. J Neurosci 1989; 9: 923-942
17. Milner TA, Pickel VM, Giuliano R, Reis DJ: Ultrastructural localization of choline acetyltransferase in the rat rostral ventrolateral medulla: evidence for major synaptic relations with non-catecholaminergic neurons. Brain Res 1989; 500: 67-89.
18. Sundaram K, Sapru H: Cholinergic nerve terminals in the ventrolateral medullary pressor area: pharmacologic evidence. J Auton Nerv Syst 1988; 22: 221-228.
19. 2 muscarinic receptors mediate pressor responses to cholinergic agonists in the ventrolateral medullary pressor area. Brain Res 1988; 449: 141-149.
20. Willette RN, Punnen S, Krieger AJ, Sapru HN: Cardiovascular control by cholinergic mechanisms in the rostral ventrolateral medulla. J Pharmacol Exp Ther 1984; 231: 457-463.
21. Punnen S, Willette RN, Krieger AJ, Sapru HN: Medullary pressor area: site of action of intravenous physostigmine. Brain Res 1986; 382: 178-184.
22. Lee SB, Kim SY, Sung KW: Cardiovascular regulation by cholinergic mechanisms in rostral ventrolateral medulla of spontaneously hypertensive rats. Eur J Pharmacol 1991; 205: 117-123.
23. Kubo T, Ishizuka T, Fukumori R, Asari T, Hagiwara Y: Enhanced release of acetylcholine in the rostral ventrolateral medulla of spontaneously hypertensive rats. Brain Res 1995; 686: 1-9.
24. Kubo T, Hashimoto M: Effects of intraventricular and intraspinal 6-hydroxydopamine on blood pressure of DOCA-saline hypertensive rats. Arch Int Pharmacodyn Ther 1979; 238: 50-59.
25. 3H]norepinephrine release from perfused mesenteric arteries of SHR and renal hypertensive rats. Eur J Pharmacol 1983; 87: 349-352.
26. Kaneda N, Nagatsu T: Highly sensitive assay for choline acetyltransferase activity by high-performance liquid chromatography with electrochemical detection. J Chromatogr 1985; 341: 23-30.
27. Da Prada M, Zurcher G: Simultaneous radioenzymatic determination of plasma and tissue adrenaline, noradrenaline and dopamine within the femtomole range. Life Sci 1976; 19: 1161-1173.
28. Ekstrom J: Acetylcholine synthesis and its dependence on nervous activity. Experientia 1978; 34: 1247-1251.
29. Brezenoff HE: Centrally induced pressor responses to intravenous and intraventricular physostigmine evoked via different pathways. Eur J Pharmacol 1973; 23: 290-292.
30. Okamura T, Miyazaki M, Inagami T, Toda N: Vascular renin-angiotensin system in two-kidney, one-clip hypertensive rats. Hypertension 1986; 8: 560-565.
31. Gavras H, Brunner HR, Laragh JH, et al: Malignant hypertension resulting from deoxycorticosterone acetate and salt excess. Role of renin and sodium in vascular changes. Circ Res 1975; 36: 300-309.