The role of central cholinergic neurons in the regulation of blood pressure and in experimental hypertension

Pharmacological Reviews

Volumn 48, Issue 2, 1996, Pages 179-211

  Buccafusco, Jerry J ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIHYPERTENSIVE AGENT; ATROPINE; CHOLINERGIC RECEPTOR STIMULATING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HEMICHOLINIUM 3; N (4 DIETHYLAMINO 2 BUTYNYL)SUCCINIMIDE; SCOPOLAMINE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD PRESSURE REGULATION; CHOLINERGIC NERVE CELL; HYPERTENSION; NONHUMAN; POLYMERASE CHAIN REACTION; POSTERIOR HYPOTHALAMUS; PRIORITY JOURNAL; SPONTANEOUSLY HYPERTENSIVE RAT; SYMPATHETIC TONE;

ANIMALS; BLOOD PRESSURE; CHOLINERGIC AGONISTS; DISEASE MODELS, ANIMAL; HUMANS; HYPERTENSION; NEURONS; POLYMERASE CHAIN REACTION; RATS; RATS, INBRED SHR; RECEPTORS, MUSCARINIC; RECEPTORS, NICOTINIC; SYNAPTIC TRANSMISSION;

EID: 0029948512     PISSN: 00316997     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (262)

1. G-nitro-L-arginine methyl ester. Life Sci. 52: PL245-PL249, 1993.
2. ALLY, A., HARA, Y., AND MURAYAMA, S.: Cardiovascular effects of central administration of cholinomimetics in anesthetized cats. Neuropharmacology 32: 185-193, 1993.
3. 2 muscarinic receptors in conscious cats. Brain Res. 677: 268-276, 1995.
4. AQUILONIUS, S.-M., AND SJOSTROM, R.: Cholinergic and dopaminergic mechanisms in Huntington's chorea. Life Sci. 10: 405-414, 1971.
5. ARNERIC, S. P., ANDERSON, E. J., BANNON, A. W., BRIGGS, C. A., BUCCAFUSCO, J. J., BRIONI, J., CANNON, J. B., DECKER, M. W., DONNELLY-ROBERTS, D., GOPALAKRISHNAN, M., HOLLADAY, M. W., KYNCL, J., MARSH, K. C., PAULY, J., RADEK, R. J., RODRIGUES, A. D., AND SULLIVAN, J. P.: Preclinical pharmacology of ABT-418: a prototypical cholinergic channel activator for the potential treatment of Alzheimer' s disease. CNS Drug Rev. 1: 1-26, 1995a.
6. ARNERIC, S. P., GIULIANO, R., ERNSBERGER, P., UNDERWOOD, M. D., AND REIS, D. J.: Synthesis, release and receptor binding of acetylcholine in the C1 area of the rostral ventrolateral medulla: contributions in regulating arterial pressure. Brain Res. 511: 98-112, 1990.
7. ARNERIC, S. P., SULLIVAN, J. P., AND WILLIAMS, M.: Neuronal nicotinic acetylcholine receptors. Novel targets for central nervous system therapeutics. In Psychopharmacology, the Fourth Generation of Progress, ed. by F. E. Bloom and D. J. Kupfer, pp. 95-110, Raven Press, New York, 1995b.
8. ARONSTAM, R. S., SMITH, M. D., AND BUCCAFUSCO, J. J.: Clonidine prevents the short-term down regulation of muscarinic receptors in the mouse brain induced by the acetylcholinesterase inhibitor soman. Neurosci. Lett. 78: 107-112, 1987.
9. ARONSTAM, R. S., MARSHALL, D. C., AND BUCCAFUSCO, J. J.: Cholinergic false transmitters: physiological and biochemical actions in central and peripheral systems. Neuropharmacology 27: 217-225, 1988.
10. ASANUMA, M., OGAWA, N., HABA, K., HIRATA, H., AND MORI, A.: Effects of chronic catecholamine depletions on muscarinic M1-receptor and its mRNA in rat brain. J. Neurol. Sci. 110: 205-214, 1992.
11. BAGETTA, G., CORASANITI, M. T., MELINO, G., PAOLETTI, A. M., FINAZZI-AGRÓ, A., AND NISTICÓ, G.: Lithium and tacrine increase the expression of nitric oxide synthase mRNA in the hippocampus of rat. Biochem. Biophys. Res. Comm. 197: 1132-1139, 1993a.
12. BAGETTA, G., MASSOUD, R., RODINÓ, FEDERICI, G., AND NISTICÓ, G.: Systemic administration of lithium chloride and tacrine increases nitric oxide synthase activity in the hippocampus. Eur. J. Pharmacol. 237: 61-64, 1993b.
13. BAGJAR, J., HRDINA, V., AND GOLDA, V.: Development of cholinergic enzymes in the brain of normal and hypertensive rats. Prog. Brain Res. 49: 471b, 1979.
14. BANNON, A. W., DECKER, M. W., WILLIAMS, M., AND ARNERIC, S. P.: Psycholtherapeutic potential of selective neuronal nicotinic acetylcholine receptor ligands. In Brain Imaging of Nicotine and Tobacco Smoking, ed. by E. F. Domino, pp. 311-334, NPP Books, Ann Arbor, MI, 1995.
15. BARBER, R. P., PHELPS, P. E., HOUSER, C. R., CRAWFORD, G. D. SALVATERRA, P. M., AND VAUGHN, J. E.: The morphology and distribution of neurons containing choline acetyltransferase in the adult rat spinal cord: an immunocytochemical study. J. Comp. Neurol. 229: 329-346, 1984.
16. BARNES, J. C., AND ROBERTS, F. F.: Central effects of muscarinic agonists and antagonists on hippocampal theta rhythm and blood pressure in the anaesthetised rat. Eur. J. Pharmacol. 195: 233-240, 1991.
17. BENTLY, G. A., AND LI, D. M. F.: Studies of the new hypotensive drug ST 155. Eur. J. Pharmacol. 4: 124-134, 1968.
18. BHARGAVA, K. P., PANT, K. K., TANGRI, K. K.: Cholinergic influences on the spinal cardiovascular neurones. J. Auton. Pharmac. 2: 225-230, 1982.
19. BICKFORD, M. E., GUNLUCK, A. E., GUIDO, W., AND SHERMAN, S. M.: Evidence that cholinergic axons from the parabrachial region of the brainstem are the exclusive source of nitric oxide in the lateral geniculate nucleus of the cat. J. Comp. Neurol. 334: 410-430, 1993.
20. BIRKENHAGER, W. H., AND REID J. L.: Experimental and genetic models of hypertension. In Handbook of Hypertension, ed. by W. De Jong, Elsevier Science Publishers B. V., New York, 1984.
21. 1 noradrenergic cells. Brain Res. 253: 161-171, 1982.
22. BONNER, T. L., BUCKLEY, N. J., YOUNG, A. C., AND BRANN, M. R.: Identification of a family of muscarinic acetylcholine receptor genes. Science (Wash. DC) 237: 527-532, 1987.
23. BONNER, T. L., YOUNG, A. C., BRANN, M. R., AND BUCKLEY, N. J.: Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. Neuron 1: 403-410, 1988.
24. BORGES, L. F., AND IVERSEN, S. D.: Topography of choline acetyltransferase immunoreactive neurons and fibers in the rat spinal cord. Brain Res. 362: 140-148, 1986.
25. BOUSQUET, P., FELDMAN, J., BLOCH, R., AND SCHWARTZ, J.: Central cardiovascular effects of alpha-adrenergic drugs: differences between catecholamines and imidazolines. J. Pharmacol. Exp. Ther. 230: 232-236, 1984.
26. BRANN, M. R., JØRGENSEN, J. E. H., HILL-EUBANKS, D., AND JONES, S. V. P.: Muscarinic acetylcholine receptor subtypes: localization and structure/function. Prog. Brain Res. 98: 121-127, 1993.
27. BREDT, D. S., AND SNYDER, S. H.: Nitric oxide, a novel neuroal messenger. Neuron 8: 3-11, 1992.
28. BREZENOFF, H. E.: Cardiovascular regulation by brain acetylcholine. Fed. Proc. 43: 17-20, 1984.
29. BREZENOFF, H. E., CARNEY, K., AND BUCCAFUSCO, J. J.: Potentiation of the carotid artery occlusion reflex by a cholinergic system in the posterior hypothalamic nucleus. Life Sci. 30: 391-400, 1982.
30. BREZENOFF, H. E., AND CAPUTI, A. P.: Intracerebroventricular injection of hemicholinium-3 lowers blood pressure in conscious spontaneously hypertensive rats but not in normotensive rats. Life Sci. 26: 1037-1048, 1980.
31. BREZENOFF, H. E., EL-FAKAHANY, E. S., AND XIAO, Y-F.: The effectof 4-DAMP mustard on blood pressure and muscarinic binding in spontaneously hypertensive rats. Ann. Neurosci. 1: 24-33, 1990.
32. BREZENOFF, H. E., AND GIULIANO, R.: Cardiovascular control by cholinergic mechanisms in the central nervous system. Ann. Rev. Pharmacol. Toxicol. 22: 341-381, 1982.
33. BREZENOFF, H. E., AND JENDEN, D. J.: Modification of arterial blood pressure in rats following microinjection of drugs into the posterior hypothalamus. Int. J. Neuropharmacol. 8: 593-600, 1969.
34. BREZENOFF, H. E., AND JENDEN, D. J.: Changes in arterial blood pressure after microinjections of carbachol into the medulla and IVth ventricle of the rat brain. Neuropharmacology 9: 341-348, 1970.
35. BREZENOFF, H. E., LI, J., AND TKACS, N.: Cholinergic stimulation of the brain increases blood pressure and evokes C-FOS expression in specific brain nuclei. Am. J. Hypertension 7: 137A, 1994.
36. 2 muscarinic receptors lowers blood pressure in spontaneously hypertensive rats. Pharmacology 36: 101-105, 1988.
37. BREZENOFF, H. E., AND XIAO, Y-F.: Acetylcholine in the posterior hypothalamic nucleus is involved in the elevated blood pressure in the spontaneously hypertensive rat. Life Sci. 45: 1163-1170, 1989.
38. BRISTOW, M. R., HERSHBERGER, R. E., PORT, J. D., GILBERT, E. M., SANDOVAL, A., RASMUSSEN, R., CATES, A. E., AND FELDMAN, A. M.: β-Adrenergic pathways in nonfailing and failing human ventricular myocardium. Circulation 82 (suppl. 1): I-12-I-25, 1990.
39. BRODY, M. J., FINK, G. D., BUGGY, J., HAYWOOD, J. R., GORDON, F. J., AND JOHNSON, A. K.: The role of the anteroventral third ventricle (AV3V) region in experimental hypertension. Circ. Res. 43 (suppl. 1): I-2-I-13, 1978.
40. BUCCAFUSCO, J. J.: Mechanism of the clonidine-induced protection against acetylcholinesterase inhibitor toxicity. J. Pharmacol. Exp. Ther. 222: 595-599, 1982.
41. BUCCAFUSCO, J. J.: Inhibition of regional brain acetylcholine biosynthesis by clonidine in spontaneously hypertensive rats. Drug Dev. Res. 4: 627-633, 1984a.
42. BUCCAFUSCO, J. J.: Inhibition of brain acetylcholine biosynthesis by methyldopa in spontaneously hypertensive rats. Brain Res. Bull. 13: 257-262, 1984b.
43. BUCCAFUSCO, J. J.: Effect of methyldopa on brain cholinergic neurons involved in cardiovascular regulation: a study in conscious spontaneously hypertensive rats. Hypertension 6: 614-621, 1984c.
44. BUCCAFUSCO, J. J.: Inhibition of brain acetylcholine biosynthesis by clonidine and methyldopa: Relevance to hypertensive disease. In Advances in Experimental Medicine, ed. by I. Hanin, pp. 1109-1111, Plenum Press, New York, 1986.
45. BUCCAFUSCO, J. J.: Neuropharmacologic and behavioral actions of clonidine: interactions with central neurotransmitters. Int. Rev. Neurobiol. 33: 55-107, 1992.
46. BUCCAFUSCO, J. J., AND ARONSTAM, R. S.: Precursors of cholinergic false transmitters: central effects on blood pressure and direct interactions with cholinergic receptors. Neuropharmacology 27: 227-233, 1988.
47. BUCCAFUSCO, J. J., AND BREZENOFF, H. E.: Mechanisms involved in the cardiovascular response to intracerebroventricular injection of noradrenaline and phentolamine. Neuropharmacology 16: 775-780, 1977.
48. BUCCAFUSCO, J. J., AND BREZENOFF, H. E.: Pharmacological study of a central cholinergic mechanism within the posterior hypothalamic nucleus which mediates a hypertensive response. Brain Res. 165: 295-310, 1979.
49. BUCCAFUSCO, J. J., AND BREZENOFF, H. E.: Opposing influences on behavior mediated by muscarinic and nicotinic receptors in the rat posterior hypothalamic nucleus. Psychopharmacology 67: 249-254, 1980.
50. BUCCAFUSCO, J. J., AND BREZENOFF, H. E.: Brain neurotransmitters and the development and maintenance of hypertension. Prog. Drug Res. 30: 127-150, 1986.
51. BUCCAFUSCO, J. J., AND JACKSON, W. J.: Beneficial effects of nicotine administered prior to a delayed matching-to-sample task in young and aged monkeys. Neurobiol. Aging 12: 233-238, 1991.
52. BUCCAFUSCO, J. J., LAPP, C. A., ARONSTAM, R. S., HAYS, A. C., AND SHUSTER, L. C.: Role of prostanoids in the regulation of central cholinergic receptor sensitivity. J. Pharmacol. Exp. Ther. 266: 314-322, 1993.
53. 2-adrenergic receptors in the antihypertensive responses evoked by central administration of clonidine analogs in conscious spontaneously hypertensive rats. J. Pharmacol. Exp. Ther. 273: 1162-1171, 1995a.
54. BUCCAFUSCO, J. J., AND MAGRI, V.: The pressor response to spinal cholinergic stimulation in spontaneously hypertensive rats. Brain Res. Bull. 25: 69-74, 1990.
55. BUCCAFUSCO, J. J., MAKARI, N. F., AND HAYS, A. C.: Pharmacological analysis of enhanced pressor response to central cholinergic stimulation in spontaneously hypertensive rats. Jpn. J. Pharmacol. 54: 105-112, 1990.
56. BUCCAFUSCO, J. J., AND SERRA, M.: Role of cholinergic neurons in the cardiovascular responses evoked by central injection of bradykinin or angiotensin II in conscious rats. Eur. J. Pharmacol. 113: 43-51, 1985.
57. BUCCAFUSCO, J. J., AND SPECTOR, S.: Role of central cholinergic neurons in experimental hypertension. J. Cardiovascular Pharmacol. 2: 347-355, 1980a.
58. BUCCAFUSCO, J. J., AND SPECTOR, S.: Influence of clonidine on experimental hypertension induced by cholinergic stimulation. Experientia 36: 671-672, 1980b.
59. BUCCAFUSCO, J. J., TERRY, JR., A. V., AND SHUSTER, L.: Spinal NMDA receptor: nitric oxide mediation of the expression of morphine withdrawal symptoms in the rat. Brain Res. 679: 189-199, 1995b.
60. BUCCAFUSCO, J. J., AND YANG, X-H: Mechanism of the hypertensive response to central injection of nicotine in conscious rats. Brain Res. Bull. 32: 35-41, 1993.
61. BUCKLEY, N. J., BONNER, T. I., AND BRANN, M. R.: Localization of a family of muscarinic receptor mRNAs in rat brain. J. Neurosci. 8: 4646-4652, 1988.
62. BYLUND, D. B., EIKENBERG, D. C., HIEBLE, J. P., LANGER, S. Z., LEFKOWITZ, R. J., MINNEMAN, K. P., MOLINOFF, P. B., RUFFOLO, R. R., AND TRENDELENBURG, U.: International union of pharmacology nomenclature of adrenoceptors. Pharmacol. Rev. 46: 121-136, 1994.
63. CANTOR, E. H., ABRAHAM, S., AND SPECTOR, S.: Central neurotransmitter receptors in hypertensive rats. Life Sci. 28: 519-526, 1981.
64. CAPPENDIJK, S. L. T., DE VRIES, R., AND DZOLJIC, M. R.: Inhibitory effect of nitric oxide (NO) synthase inhibitors on naloxone-precipitated withdrawal syndrome in morphine-dependent mice. Neurosci. Lett. 162: 97-100, 1993.
65. CASTO, R., AND PRINTZ, M. P.: Genetic transmission of hyperresponsivity in crosses between spontaneously hypertensive and Wistar-Kyoto rats. J. Hypertension 6 (suppl. 4): S52-S54, 1988.
66. CASTO, R., AND PRINTZ, M. P.: Exaggerated response to alerting stimuli in spontaneously hypertensive rats. Hypertension 16: 290-300, 1990.
67. CASTOLDI, A. F., MANZO, L., AND COSTA, L. G.: Cyclic GMP formation induced by muscarinic receptors is mediated by nitric oxide synthesis in rat cortical primary cultures. Brain Res. 610: 57-61, 1993.
68. CHENG, J. B., AND SHIBATA, S.: Pressor response to 5-hydroxytryptamine, norepinephrine and KCl in the perfused hindquarter preparation form the spontaneously hypertensive rat. J. Pharmacol. Exp. Ther. 214: 488-495, 1980.
69. COCHRANE, K. L., BUCHHOLZ, R. A., HUBBARD, J. W., KEETON, T. K., AND NATHAN, M. A.: Hypotensive effects of lesions of the rostral ventrolateral medulla in rats are anesthetic-dependent. J. Autonom. Nerv. Sys. 22: 181-187, 1988.
70. COHN, J. N.: Abnormalities of peripheral sympathetic nervous system control in congestive heart failure. Circulation 82 (suppl. 1): I-59-I-67, 1990.
71. COLLIER, B., BOKSA, P., AND LOVAT, S.: Cholinergic false transmitters. Prog. Brain Res. 49: 107-121, 1979.
72. COLLINS, R., PETO, R., MACMAHON, S., HEBERT, P., FIEBACH, N. H., EBERLEIN, K. A., GODWIN, J., QIZILBASH, N., TAYLOR, J. O., AND HENNEKENS, C. H.: Blood pressure, stroke, and coronary heart disease. Lancet 335: 827-838, 1990.
73. CORAM, W. M., AND BREZENOFF, H. E.: The antihypertensive effect of a selective central muscarinic cholinergic antagonist: N-(4-diethylamino-2-butynyl)-succinimide. Drug Dev. Res. 3: 503-516, 1983.
74. CRISCIONE, L., REIS, D. J., AND TALMAN, W. T.: Cholinergic mechanisms in the nucleus tractus solitarii and cardiovascular regulation in the rat. Eur. J. Pharmacol. 88: 47-55, 1983.
75. CRUICKSHANK, J. M., THORP, J. M., AND ZACHARIAS, F. J.: Benefits and potential harm of lowering high blood pressure. Lancet 8533: 581-583, 1989.
76. CUTLER, J. A., MACMAHON, S. W., AND FURBERG, C. D.: Controlled clinical trials of drug treatment for hypertension. Hypertension 13 (suppl. 1): I-36-I-44, 1989.
77. DAGE, R. C.: A centrally mediated prolonged hypotension produced by oxotremorine or pilocarpine. Br. J. Pharmac. 65: 15-21, 1979.
78. DAHLBOM, R., KARLEN, B., GEORGE, R., AND JENDEN, D. J.: Synthesis and pharmacology of N-(4- dietylamino-2-butynyl)-succinimide (DKJ-21), a new central anticholinergic agent. Life Sci. 5: 1625-1631, 1966.
79. DALY, P. A., AND SOLE, M. J.: Myocardial catecholamines and the pathophysiology of heart failure. Circulation 82 (suppl. 1): I-35-I-43, 1990.
80. DAMPNEY, R. A. L.: Functional organization of central pathways regulating the cardiovascular system. Physiol. Rev. 74: 323-364, 1994.
81. DECK, R., OBERDORF, A., AND KRONEBERG, G.: Die wirkung von 2-(2, 6-dichlorophenylamino-2- imidazolin-hydrochlorid (Clonidin) auf die kontrakton und die acetylcholin-freisetzung am isolierten koaxiel eletrisch gereizten meerschweincheileum. Arzneim-Forsch 21: 1580-1584, 1971.
82. DIETZ, R., SCHÖMIG, A., HAEBARA, H., MANN, J. F. E., RASCHER, W., LÜTH, J. B., GRÜNHERZ, N., AND GROSS, F.: Studies on the pathogenesis of spontaneous hypertension of rats. Circ. Res. 43 (suppl. 1): I98-I106, 1978.
83. DREW, G. M.: Pharmacological charaterization of the presynaptic α-adrenoceptors regulating cholinergic activity in the guinea-pig brain. Br. J. Pharmacol. 64: 293-300, 1978.
84. ECKERSDORF, B., GOLBIEWSKI, H., AND LEWINSKA, M. K.: Kainic acid lesions of the cat's anteromedial hypothalamus and emotional-defensive response evoked by carbachol injection to the same loci. Behav. Brain Res. 24: 161-166, 1987.
85. EDERY, H., GEYER, M. A., TAYLOR, P., AND BERMAN, H. A.: Target sites for anticholinesterase on the ventral surface of the medulla oblongata: hypotension elicited by organophosphorous agents. J. Auton. Pharmacol. 6: 195-205, 1986.
86. ELROD, K., BUCCAFUSCO, J. J., AND JACKSON, W. J.: Nicotine enhances delayed matching-to-sample performance by primates. Life Sci. 43: 277-287, 1988.
87. 2-adrenoceptors in the ventrolateal medulla. Eur. J. Pharmacol. 134: 1-13, 1987.
88. ERNSBERGER, P., MEELEY, M. P., AND REIS, D. J.: An endogenous substance with clonidine-like properties: selective binding to imidazole sites in the ventrolateral medulla. Brain Res. 441: 309-318, 1988.
89. EVA, C., FUSCO, M., BONO, C., TRIA, M. A., GAMALERO, S. R., LEON, A., AND GENAZZANI E.: Nerve growth factor modulates the expression of muscarinic cholinergic receptor messenger RNA in telencephalic neuronal cultures from newborn rat brain. Molecular Br. Res. 14: 344-351, 1992.
90. FELDBERG, W., AND GUERTZENSTEIN, P. G.: Vasodepressor effects obtained by drugs acting on the ventral surface of the brain stem. J. Physiol. 258: 337-355, 1976.
91. FELDMAN, D. S., AND BUCCAFUSCO, J. J.: Role of NMDA receptors and nitric acid synthase in the pressor response to spinal cholinergic stimulation. Pharmacol. Abs. 34: 166, 1992.
92. FELDMAN, D. S., AND BUCCAFUSCO, J. J.: Localization of cholinergic neurons involved in the cardiovascular response to intrathecal injection of carbachol. Eur. J. Pharmacol. 250: 483-487, 1993a.
93. FELDMAN, D. S., AND BUCCAFUSCO, J. J.: Role of glutamate and nitric oxide on the pressor response to spinal cholinergic stimulation in freely moving rats. Soc. Neurosci. Abs. 19: 313, 1993b.
94. FOLKOW, B., AND RUBINSTEIN, E. H.: Cardiovascular effects of acute and chronic stimulation of the defense area in the rat. Acta Physiol. Scand. 68: 48-57, 1966.
95. FREEMAN, H., AND CARMICHAEL, H. P.: A pharmacodynamic study of the autonomic nervous system in normal men. The effects of intravenous injection of epinephrine, atropine, ergotomine and physostigmine upon the blood pressure and pulse rate. J. Pharmacol. Exp. Ther. 58: 409-416, 1936.
96. GATTU, M., URBANAWIZ, S. E., PAULY, J. R., AND BUCCAFUSCO, J. J.: Estimation of nicotinic receptor binding sites in the CNS of spontaneously hypertensive (SHR) and normotensive rats by autoradiography. Soc. Neurosci. Abs. 21: 1403, 1995a.
97. 2 binding sites in the CNS of spontaneously hypertensive (SHR) and normotensive rats. FASEB J. 9: A46, 1995b.
98. GIBSON, I. C., AND LOGAN, S. D.: Effects of muscarinic receptor stimulation of sympathetic preganglionic neurones of neonatal rat spinal cord in vitro. Neuropharmacology 34: 309-318, 1995.
99. GILLIS, R. A., WALTON, D. P., QUEST, J. A., NAMATH, I. J., HAMOSH, P., AND DRETCHEN, K. L.: Cardiorespiratory effects produced by activation of cholinergic muscarinic receptors on the ventral surface of the medulla. J. Pharmacol. Exp. Ther. 247: 765-773, 1988.
100. GIULIANO, R., AND BREZENOFF, H. E.: Increased central cholinergic activity in rat models of hypertension. J. Cardiovasc. Pharmacol. 10: 113-122, 1987.
101. GIULIANO, R., RUGGIERO, D. A., MORRISON, S., ERNSBERGER, P., AND REIS, D. J.: Cholinergic regulation of arterial pressure by the C1 area of the rostral ventrolateral medulla. J. Neurosci. 9: 923-942, 1989.
102. GOLDBERG, A. M.: Is deanol a precursor of acetylcholine? Practical J. Psych./ Neurol. 38: 16-20, 1977.
103. GORDON, F. J., BRODY, M. J., FINK, G. D., BUGGY, J., AND JOHNSON, A. K.: Role of central catecholamines in the control of blood pressure and drinking behavior. Brain Res. 178: 161-173, 1979.
104. GORDON, F. J., BRODY, M. J., AND JOHNSON, A. K.: Regional depletion of central nervous system catecholamines: effects on blood pressure and drinking behavior. Brain Res. 345: 285-297, 1985.
105. GORDON, F. J.: Spinal GABA receptors and central cardiovascular control. Brain Res. 328: 165-169, 1985.
106. GORDON, F. J.: Aortic baroreceptor reflexes are mediated by NMDA receptors in caudal and ventrolateral medulla. Am. J. Physiol. 252: R628-R633, 1987.
107. GRANATA, A. R., RUGGIERO, D. A., PARK., D. H., JOH, T. H., AND REIS, D. J.: Brain stem area with C1 epinephrine neurons mediates baroreflex vasodepressor responses. Am. J. Physiol. 248: H547-H567, 1985.
108. GUYENET, P. G., FILTZ, T. M., AND DONALDSON, S. R.: Role of excitatory amino acids in rat vagal and sympathetic baroreflexes. Brain Res. 407: 272-284, 1987.
109. HALLBÄCK, M.: Interaction between central neurogenic mechanisms and changes in cardiovascular design in primary hypertension. Experimental studies in spontaneously hypertensive rats. Acta Physiol. Scand. 424 (suppl.): 3-59, 1975.
110. HARA, Y., ALLY, A., AND MURAYAMA, S.: Central cardiovascular effects of physostigmine in anesthetized cats. Neuropharmacology 31: 923-928, 1992.
111. HARTLE, D. K., AND BRODY, M. J.: The angiotensin II pressor system of the rat forebrain. Circ. Res. 54: 355-366, 1984.
112. HAYS, A. C., SULLIVAN, M. H., HALLOWES, W. C., AND BUCCAFUSCO, J. J.: Acceleration of central muscarinic receptor tolerance by indomethacin. Soc. Neurosci. Abs. 15: 1218, 1989.
113. HELKE, C. J., MUTH, E. A., AND JACOBOWITZ, D. M.: Changes in central cholinergic neurons in the spontaneously hypertensive rat. Brain Res. 188: 425-436, 1980.
114. HENRY, R., CASTO, R., AND PRINTZ, M. P.: Diurnal cardiovascular patterns in spontaneously hypertensive and Wistar-Kyoto rats. Hypertension 16: 422-428, 1990.
115. HERSHKOWITZ, M., ELIASH, S., AND COHEN, S.: The muscarinic cholinergic receptors in the posterior hypothalamus of hypertensive and normotensive rats. Eur. J. Pharmacol. 86: 229-236, 1983.
116. HOFFMAN, W. E., AND PHILLIPS, M. I.: A pressor response to intraventricular injections of carbachol. Brain Res. 105: 157-162, 1976.
117. HOFFMAN, W. E., SCHMID, P. G., AND PHILLIPS, M. I.: Central cholinergic and noradrenergic stimulation in spontaneously hypertensive rats. J. Pharmacol. Exp. Ther. 206: 644-651, 1978.
118. HOLLAND, L. N., SHUSTER, L. C., AND BUCCAFUSCO, J. J.: Role of spinal and supraspinal muscarinic receptors in the expression of morphine withdrawal symptoms in the rat. Neuropharmacology 32: 1387-1395, 1993.
119. JANOWSKY, D. S., DAVIS, J. M., EL-YOUSEF AND SEKERKE, H. J.: Acetylcholine and depression. Psychosom. Med. 34: 459, 1973.
120. JANOWSKY, D. S., RISCH, S. C., HEUY, L. Y., KENNEDY, B., AND ZIEGLER, M.: Effects of physostigmine on pulse, blood pressure, and serum epinephrine levels. Am. J. Psych. 142: 738-740, 1985.
121. JANOWSKY, D. S., RISCH, S. C., KENNEDY, B., ZIEGLER, M., AND HUEY, L.: Central muscarinic effects of physostigmine on mood, cardiovascular function, pituitary and adrenal neuroendocrine release. Psychopharmacology 89: 150-154, 1986.
122. JOPE, R. S.: High affinity choline transport and acetylCoA production in brain and their roles in the regulation of acetylcholine synthesis. Brain Res. Rev. 1: 313-344, 1979.
123. JUDY, W. V., WATANABE, A. M., HENRY, D. P., BESCH, H. R., MURPHY, W. R., AND HOCKEL, G. M.: Sympathetic nerve activity: Role in regulation of blood pressure in the spontaneously hypertensive rat. Circ. Res. 38: 1121-1129, 1976.
124. JUDY, W. V., WATANABE, A. M., MURPHY, W. R., APRISON, B. S., AND YU, P. L.: Sympathetic nerve activity and blood pressure in normotensive backcross rats genetically related to the spontaneously hypertensive rat. Hypertension 1: 598-604, 1979.
125. KARMOS-VÁRSZEGI, M., AND KARMOS, G.: A comparative study of autonomic, somatic and bioelectric correlates of emotional reactions elicited by cholinergic stimulation of the hypothalamus and the ventral tegmentum. Act. Nerv. Super. (Praha) 19: 123-124, 1977.
126. KAWASHIMA, K., FUJIMOTO, K., MIWA, Y., AND MAEMURA, S.: A relationship of central cholinergic functions with enhanced cardiovascular responses to physostigmine in the spontaneously hypertensive rat. J. Hypertens. 4 (suppl. 3): S167-S169, 1986.
127. KAWASHIMA, K., MIWA, Y., AND FUJIMOTO, K.: Possible involvement of an impaired baroreflex mechanism but not the renin-angiotensin system and vasopressin in the enhanced pressor responsiveness to physostigmine in spontaneously hypertensive rats. Gen. Pharmac. 18: 327-330, 1987.
128. KENNEDY, B., JANOWSKY, D. S., RISCH, S. C., AND ZIEGLER, M.: Central cholinergic stimulation causes adrenal epinephrine release. J. Clin. Invest. 74: 972-975, 1984.
129. KHAN, I. M., PRINTZ, M. P., YAKASH, T. L., AND TAYLOR, P.: Augmented responses to intrathecal nicotinic agonists in spontaneous hypertension. Hypertension 24: 611-619, 1994a.
130. KHAN, I. M., TAYLOR, P., AND YAKASH, T. L.: Stimulatory pathways and sites of action of intrathecally administered nicotinic agents. J. Pharmacol. Exp. Ther. 271: 1550-1557, 1994b.
131. KHAN, I. M., TAYLOR, P., AND YAKASH, T. L.: Cardiovascular and behavioral responses to nicotinic agents administered intrathecally. J. Pharmacol. Exp. Ther. 270: 150-158, 1994c.
132. KOBINGER, W.: Central α-adrenergic systems as targets for hypotensive drugs. Rev. Physiol. Biochem. Pharmacol. 81: 39-100, 1978.
133. KORNER, P. I.: Central control of blood pressure: implications in the pathophysiology of hypertension. In Regulation of blood pressure by the central nervous system, ed. by G. Onesti, M. Fernandes and K. E. Kim, pp. 3-20, Grune & Stratton, New York, 1976.
134. KRUKOFF, T. L.: Decreased hexokinase activity in paraventricular nucleus of adult SHR and renal hypertensive rats. Am. J. Physiol. 254: R508-R512, 1988.
135. KRSTIĆ, M. K.: A further study of the cardiovascular responses to central administration of acetylcholine in rats. Neuropharmacology 21: 1151-1162, 1982.
136. KRSTIĆ, M. K., AND DJURKOVIĆ, D.: Cardiovascular response to intracerebroventricular administration of acetylcholine in rats. Neuropharmacology 17: 341-347, 1978.
137. KRSTIĆ, M. K., AND DJURKOVIĆ, D.: Modification by physostigmine of the cardiovascular responses to intracerebroventricular administration of 5-hydroxytryptamine in rats. Arch. Int. Physiol. Biochem. 95: 153-158, 1987.
138. KUBO T., FUKUDA K., MIKAMI A., TAKAHASHI H., MISHINA M., HAGA T., HAGA K., ICHIYAMA A., KANGAWA K., KOJIMA M., MATSUO H., HIROSE T., AND NUMA S.: Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor. Nature (Lond.) 323: 560-561, 1986.
139. KUBO, T., ISHIZUKA, T., FUKUMORI, R., ASARI, T., AND HAGIWARA, Y.: Enhanced release of acetylcholine in the rostral ventrolateral medulla of spontaneously hypertensive rats. Brain Res. 686: 1-9, 1995.
140. KUBO, T., AND TATSUMI, M.: Increased pressor responses to physostigmine in spontaneously hypertensive rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 306: 81-83, 1979.
141. KUHAR, M. J., AND MURRIN, L. C.: Sodium-dependent high affinity choline uptake. J. Neurochem. 30: 15-21, 1978.
142. KURTZ T. W., CASTO R., SIMONET L., AND PRINTZ M. P.: Biometric genetic analysis of blood pressure in the spontaneously hypertensive rat. Hypertension 16: 718-724, 1990.
143. KURTZ, T., AND MORRIS, R.: Biological variability in Wistar-Kyoto rats: implications for research with the spontaneously hypertensive rat. Hypertension 10: 127-131, 1987.
144. LAUBIE, M.: Recent Advances in Hypertension, ed. by P. Milliez and M. Safar, Societe Aliena, Reims,1975.
145. LEE, N. H., AND FRASER, C. M.: Post-transcriptional regulation of the m1 muscarinic acetylcholine receptor (abstract). Life Sci. 52: 562, 1993.
146. LEIŠIĆ, R., AND VARAGIĆ, V.: Factors influencing the hypertensive effect of eserine in the rat. Br. J. Pharmacol. 16: 99-107, 1961.
147. LEVEY, A. I., KITT, C. A., SIMONDS, W. F., PRICE, D. L., AND BRANN, M. R.: Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J. Neurosci. 11: 3218-3226, 1991.
148. LEVIN, E. D.: Nicotinic systems and cognitive function. Psychopharmacology 108: 417-431, 1992.
149. LIN, Q., AND LI, P.: Rostral medullary cholinergic mechanisms and chronic stress-induced hypertension. J. Auton. Nerv. Syst. 31: 211-218, 1990.
150. LIN, R. F., LIN, T-S., TILTON, R. G., AND CROSS, A. H.: Nitric oxide localized to spinal cords of mice with experimental allergic encephalomyelitis: an electron paramagnetic resonance study. J. Exp. Med. 178: 643-648, 1993.
151. LIUZZI, F. J., WU, W., SCOVILLE, S. A., AND SCHINCO, F. P.: Development of nitric oxide synthase expression in the superficial dorsal horn of the rat spinal cord. Exp. Neurol. 121: 275-278, 1993.
152. 2 mRNA in cerebellar granule cells by carbachol. J. Pharmacol. Exp. Ther. 265: 441-446, 1993.
153. LORENZ, R. G., SAPER, C. B., WONG, D. L., CIARANELO, R. D., AND LOEWY, A. D.: Co-localization of substance P- and phenylethanolamine-N-methyltransferase-like immunoreactivity in neurons of ventrolateral medulla that project to the spinal cord: potential role in control of vasomotor tone. Neurosci. Lett. 55: 255-260, 1985.
154. MAGRI, V., AND BUCCAFUSCO, J. J.: Hypertension following intrathecal injection of cholinergic agonists in conscious rats: role of endogenous acetylcholine. J. Auton. Nerv. Syst. 25: 69-77, 1988.
155. MAKARI, N. F., TRIMARCHI, G. R., AND BUCCAFUSCO, J. J.: Contribution of pre-and post-synaptic components to heightened central cholinergic activity in spontaneously hypertensive rats. Neuropharmacology 28: 379-386, 1989.
156. MALHOTRA, V., KACHROO, A., AND SAPRU, H. N.: Role of α1-adrenergic receptors in the intermediolateral column in mediating the pressor responses elicited by the stimulation of ventrolateral medullary pressor area. Brain Res. 626: 278-286, 1993.
157. MARSHALL, D. C., AND BUCCAFUSCO, J. J.: Supraspinal and spinal mediation of naloxone induced morphine withdrawal in rats. Brain Res. 329: 131-142, 1985.
158. MARSHALL, D. C., AND BUCCAFUSCO, J. J.: Spinal cholinergic neurons and the expression of morphine withdrawal symptoms in the rat. J. Neurosci. 7: 621-628, 1987.
159. 2 receptors in the central regulation of the cardiovascular system. Pharmacol. Rev. 46: 231-243, 1994.
160. MCCARTY, R., CHIUEH, C. C., AND KOPIN, I. J.: Spontaneously hypertensive rats: adrenergic hyperresponsivity to anticipation of electric shock. Behav. Biol. 23: 180-188, 1978.
161. MCCARTY, R., KIRBY, R. F., CIERPIAL, M. A., AND JENAL, T. J.: Accelerated development of cardiac sympathetic responses in spontaneously hypertensive (SHR) rats. Behav. Neural. Biol. 48: 321-333, 1987.
162. MCDONALD, B. E., COSTA, L. G., AND MURPHY, S. D.: Spatial memory impairment and central muscarinic receptor loss following prolonged treatment with organophosphates. Toxicol. Lett. 40: 47-56, 1988.
163. MCGRIFF, J. C., AND QUILLEY, C. P.: The rat with spontaneous genetic hypertension is not a suitable model of human essential hypertension. Circ. Res. 48: 455-463, 1981.
164. MCKINNEY, M.: Muscarinic receptor subtype-specific coupling to second messengers in neuronal systems. Prog. Brain Res. 98: 333-340, 1993.
165. MCKINNEY, M., AND COYLE, J. T.: The potential for muscarinic receptor subtype-specific pharmacotherapy for Alzheimer's disease. Mayo Clin. Proc. 66: 1225-1237, 1991.
166. MELLER, S. T., DYKSTRA, C., AND GEBHART, G. R.: Production of endogenous nitric oxide and activation of soluble guanylate cyclase are required for N-methyl-D-aspartate-produced facilitation of the nonciceptive tail-flick reflex. Eur. J. Pharmacol. 214: 93-96, 1992.
167. MENANI, J. V., SAAD, W. A., ARRUDA CAMARGO, L. A., RENZI, A., DE LUCA JR., L. A., AND COLOMBARI, E.: The anteroventral third ventricle (AV3V) region is essential for pressor, dipsogenic and natriuretic responses to central carbachol. Neurosci. Lett. 113: 339-344, 1990.
168. MILNER, T. A., PICKEL, V. M., GIULIANO, R., AND REIS, D. J.: Ultrastructural localization of choline acetyltransferase in the rat rostral ventrolateral medulla: Evidence for major synaptic relations with non-catecholaminergic neurons. Brain Res. 500(1-2): 67-89, 1989.
169. MIYAZAKI, T., COOTE, J. H., AND DUN, N. J.: Excitatory and inhibitory effects of epinephrine on neonatal rat sympathetic preganglionic neurons in vitro. Brain Res. 497: 108-116, 1989.
170. MONTASTRUC, J. L., DANG TRAN, L., HUCHET-BRISAC, A. M., CHELLY, J., ROSTIN, M., AND MONTASTRUC, P.: Involvement of cholinergic mechanisms in the central cardiovascular actions of nicardipine in dogs. Arch. Int. Pharmacodyn. 289: 212-216, 1987.
171. MOORE, A. F., AND DREXLER A. P.: A cholinergic link in the centrally mediated actions of angiotensin II. Drug Dev. Res. 2: 241-250, 1982.
172. MORRISON, S. F., MILNER, T. A., AND REIS, D. J.: Reticulospinal vasomotor neurons of the rat rostral ventrolateral medulla: relationship to sympathetic nerve activity and the C1 adrenergic cell group. J. Neurosci. 8: 1286-1301, 1988.
173. MURUGAIAN, J., SUNDARAM, K., AND SAPRU, H.: Cholinergic mechanisms in the ventrolateral depressor area. Brain Res. 501: 355-363, 1989.
174. MYERS, R. D.: Emotional and autonomic responses following hypothalamic chemical stimulation. Can. J. Pharmacol. 18: 6-14, 1964.
175. NATTEL, S., BAYNE, L., AND RUEDY, J.: Physostigmine in coma due to drug overdose. Clin. Pharmacol. Ther. 25: 96-102, 1979.
176. NILSSON, E., MERETOJA, O. A., AND NEUVONEN, P.: Hemodynamic responses to physostigmine in patients with a drug overdose. Aesth. Analg. 62: 885-888, 1983.
177. 1-receptor and its mRNA in the gerbil hippocampus. Brain Res. 591: 171-175, 1992.
178. 2 in the brain-stem of stroke- resistant spontaneously hypertensive rats. J. Nutr. Sci. Vitaminol. 26: 343-347, 1980.
179. OISHI, S., YURENEV, A., PARFYONOVA, E., LEE, D. D., DUBOV, P., NIKULIN, I., KOSENKO, A., KONYAEVA, E., BALYAKINA, E., ATAKHANOV, S., AND DEQUATTRO, V.: Altered sympathetic tone in hypertensives with angina and lowered threshold for pacing ischemia. Amer. J. Hypertens. 5: 154S-163S, 1991.
180. OKAMOTO, K., AND AOKI, K.: Development of a strain of spontaneously hypertensive rats. Jpn. Circ. J. 27: 282-293, 1963.
181. OKUDA, C., MIZOBE, T., AND MIYAZAKI, M.: The involvement of central cholinergic mechanisms in cardiovascular responses to intracerebroventricular and intravenous administration of thyrotropin-releasing hormone. Life Sci. 40: 1293-1299, 1987.
182. OPPENHEIMER, E., AKAVIA, E., SHAVIT, S., AND KORCZYN, A. D.: Sympathomimetic amines and cardiac arrhythmias. Cardiovasc. Res. 24: 754-757, 1990.
183. PAGANI, M., MAZZUERO, G., FERRARI, A., LIBERATI, D., CERUTTI, S., VAITL, D., TAVAZZI, L., AND MALLIANI A.: Sympathovagal interaction during mental stress. Circulation 83 (suppl. 2): II-43-II-51, 1991.
184. PARK, K. H., AND LONG, J. P.: Modulation by physostigmine of head-up tilt- and bilateral carotid occlusion-induced baroreflexes in rats. J. Pharmacol. Exp. Ther. 257 (suppl. 1): 50-55, 1991.
185. PAULETTO, P., SCANNAPIECO, G., AND PESSINA, A. C.: Sympathetic drive and vascular damage in hypertension and atherosclerosis. Hypertension 17 (suppl. 3): III-75-III-81, 1991.
186. PAZO, J. H., AND MEDINA, J. H.: Cholinergic mechanisms within the caudate nucleus mediate changes in blood pressure. Neuropharmacology 22: 717-720, 1983.
187. 2 receptor subtype. Eur. J. Pharmacol. 125: 63-70, 1986.
188. PERALTA E. G., ASHKENAZI A., WINSLOW J. W., SMITH D. H., RAMACHANDRAN J., AND CAPON D. J.: Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. EMBO J 6: 3923-3929, 1987.
189. PHILIPPU, A.: Involvement of cholinergic systems of the brain in the central regulation of cardiovascular functions. J. Auton. Pharmacol. 1: 321-330, 1981.
190. PODRID, P. J., FUCHS, T., AND CANDINAS, R.: Role of the sympathetic nervous system in the genesis of ventricular arrhythmia. Circulation 82 (suppl. 1): I-103-I-113, 1990.
191. POLINSKY, R. J., BROWN, R. T., CURRAS, M. T., BASER, S. M., BAUCOM, C. E., HOOPER, D. R., AND MARINI, A. M.: Central and peripheral effects of arecoline in patients with autonomic failure. J. Neurol. Neurosurg. Psychiatry 54: 807-812, 1991.
192. PRICE, R. H. JR., MAYER, B., AND BEITZ, A. J.: Nitric oxide synthase neurons in rat brain express more NMDA receptor mRNA than non-NOS neurons. Neuroreport 4: 807-810, 1993.
193. PUNNEN, S., WILLETTE, R. N., KRIEGER, A. J., AND SAPRU, H. H.: Medullary pressor area: Site of action of intravenous physostigmine. Brain Res. 382: 178-184, 1986.
194. REIS, D. J., DOBA, N., AND NATHAN, M. A.: Neurogenic arterial hypertension produced by brainstem lesions. In Regulation of Blood Pressure by the Central Nervous System, ed. by G. Onesti, M. Fernandes and K. E. Kim, pp. 35-51, Grune & Stratton, New York, 1976.
195. REIS, D. J., ROSS, C. A., GRANATA, A. R., AND RUGGIERO, D. A.: Role of the C1 area of rostroventrolateral medulla in cardiovascular control. In Brain Peptides and Catecholamines in Cardiovascular Regulation, ed. by J. P. Buckley and C. M. Ferrario, pp. 1-14, Raven Press, New York, 1987.
196. 2 release from the hypothalamus. Proc. Natl. Acad. Sci. USA 891: 1543-11546, 1992.
197. RIBEIRO-DA-SILVA, A., AND CUELLO, A. C.: Choline acetyltransferase-immunoreactive profiles are presynaptic to primary sensory fibers in the rat superficial dorsal horn. J. Comp. Neurol. 295: 370-384, 1990.
198. RISCH, S. C., KALIN, N. H., AND JANOWSKY, D. S.: Cholinergic challenges in affective illness, behavioral and neuroendocrine correlates. J. Clin. Psychopharmacol. 1: 186-192, 1981.
199. ROBINSON, S. E.: Interaction of the median raphe nucleus and hypothalamic serotonin with cholinergic agents and pressor responses in the rat. J. Pharmacol. Exp. Ther. 223: 662-668, 1982.
200. RUGGIERO, D. A., GIULIANO, R., ANWAR, M., STORNETTA, R., AND REIS, D. J.: Anatomical substrates of cholinergic-autonomic regulation in the rat. J. Comp. Neurol. 292: 1-53, 1990.
201. RUGGIERO, D. A., STRONETTA, R. L., MORRISON, S. F., AND REIS, D. J.: Spinal projections to brainstem autonomic centers. Soc. Neurosci. Abstr. 12: 1156, 1986.
202. 2 in cardiovascular function in rat. Brain Res. 330: 167-169, 1985.
203. SAKAGUCHI, A., LEDOUX, J. E., AND REIS, D. J.: Sympathetic nerves and adrenal medulla: Contributions to cardiovascular-conditioned emotional responses in spontaneously hypertensive rats. Hypertension 5: 728-738, 1983.
204. SAPRU, H. N.: Cholinergic mechanisms subserving cardiovascular function in the medulla and spinal cord. Prog. Brain Res. 81: 171-179, 1989.
205. SCHMITT, H.: The pharmacology of clonidine and related products. In Handbook of Experimental Pharmacology, Antihypertensive Agents, ed. by F. Gross, vol. 39, pp. 299-396, Springer-Verlag, New York, 1977.
206. SCHUMAN, E. M., AND MADISON, D. V.: The intracellular messenger nitric oxide is required in long-term potentiation. Science (Wash. DC) 254: 1503-1506, 1991.
207. SESSA, W. C., HARRISON, J. K., LUTHIN, D. R., POLLOCK, J. S., AND LYNCH, K. R.: Genomic analysis and expression patterns reveal distinct genes for endothelial and brain nitric oxide synthase. Hypertension 21: 934-938, 1993.
208. SHIBUKI, K., AND OKADA, D.: Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum. Nature (Lond.) 349: 326-328, 1991.
209. SMITH, J. K., AND BARRON, K. W.: Cardiovascular effects of L-glutamate and tetrodotoxin microinjected into the rostral and caudal ventrolateral medulla in normotensive and spontaneously hypertensive rats. Brain Res. 506: 1-8, 1990a.
210. SMITH, J. K., AND BARRON, K. W.: The rostral and caudal ventrolateral medulla in young spontaneously hypertensive rats. Brain Res. 506: 153-158, 1990b.
211. SMITH, M. D., YANG, X., NHA, J.-Y., AND BUCCAFUSCO, J. J.: Antinociceptive effect of spinal cholinergic stimulation: interaction with substance P. Life Sci. 45: 1255-1261, 1989.
212. STAMENOVIC, B. A., AND VARAGIC, V. M.: The effect of reserpine on the efferent neuronal activity in the cervical sympathetic of the rat. Neuropharmacology 9: 561-566, 1970.
213. STEWART, R. D.: Tricyclic antidepressant poisoning. Am. Family Physician 19: 136-144, 1979.
214. SUH, T. H., WANG, C. H., AND LIM, R. K. S.: The effect of intracisternal applications of acetylcholine and the localization of the pressor centre and tract. Chin. J. Physiol. 10: 61-79, 1936.
215. 2 muscarinic receptors mediate pressor responses to cholinergic agonists in the ventrolateral medullary perssor area. Brain Res. 449: 141-149, 1988.
216. 3 increase heart rate and contractility. Brain Res. 503: 22-31, 1989a.
217. SUNDARAM, K., MURUGAIAN, J., WATSON, M., AND SAPRU, H.: M2 muscarinic receptor agonists produce hypotension and bradycardia when injected into the nucleus tractus solitarii. Brain Res. 477: 358-362, 1989b.
218. SUNDARAM, K., AND SAPRU, H.: Cholinergic nerve terminals in the ventrolateral medullary pressor area: pharmacological evidence. J. Auton. Nerv. Syst. 22: 221-228, 1988.
219. 2-adrenoceptor that blocks coupling to potassium but not calcium currents. Science (Wash. DC) 257: 977-980, 1992.
220. SVENSSON, L., HARTHON, C., AND LINDER, B.: Evidence for a dissociation between cardiovascular and behavioral reactivity in the spontaneously hypertensive rat. Physiol. Behav. 49: 661-665, 1991.
221. 2-adrenoceptors and brain cholinergic stimulation in sinoarotic denervated rats. Eur. J. Pharmacol. 271: 9-16, 1994.
222. TAKAHASHI, H., AND BUCCAFUSCO, J. J.: The sympathoexcitatory response following selective activation of a spinal cholinergic system in anesthetized rats. J. Auto. Nerv. Sys. 34: 59-68, 1991a.
223. TAKAHASHI, H., AND BUCCAFUSCO, J. J.: Spinal cholinergic modulation of cardiovascular tone and a somatosympathetic reflex response. Brain Res. Bull. 27: 47-51, 1991b.
224. TAKAHASHI, H., AND BUCCAFUSCO, J. J.: Excitatory modulation by a spinal cholinergic system of a descending sympathoexcitatory pathway in rats. Neuropharmacology 31: 259-269, 1992.
225. TAKAHASHI, H., INOUE, A., TAKEDA, K., OKAJIMA, H., SASAKI, S., YOSHIMURA, M., NAKAGAWA, M., AND IJICHI, H.: Augmented central cholinergic mechanisms in spontaneously hypertensive rats: Involvement of deranged noradrenergic mechanisms in the brain. Jpn. Heart J. 25: 397-410, 1984.
226. TALMAN, W. T., COLLING, J-M. E. K., AND ROBERTSON, S. C.: Glycine microinjected into nucleus tractus solitarii of rat acts through cholinergic mechanisms. Am. J. Physiol. 260: H1326-H1331, 1991.
227. TALMAN, W. T., AND LEWIS, S. J.: Altered cardiovascular responses to glutamate and acetylcholine microinjected into the nucleus tractus solitarii of the SHR. Clin. Exp. Hypertens. 13 (suppl. 5): 661-668, 1991.
228. TERENGHI, G., RIVEROS-MORENO, V., HUDSON, L. D., IBRAHIM, N. B. N., AND POLAK, J. M.: Immunohistochemistry of nitric oxide synthase demonstrates immunoreactive neurons in spinal cord and dorsal root ganglia of man and rat. J. Neurolog. Sci. 118: 34-37, 1993.
229. TERRY, A. V., JR., BUCCAFUSCO, J. J., AND JACKSON, W. J.: Scopolamine reversal of nicotine enhanced delayed matching-to-sample performance by monkeys. Pharmacol. Biochem. Behav. 45: 925-929, 1993.
230. TRIMARCHI, G. R., AND BUCCAFUSCO, J. J.: Changes in regional brain synaptosomal high affinity choline uptake during the development of hypertension in spontaneously hypertensive rats. Neurochem. Res. 12: 247-254, 1987.
231. TRIMARCHI, G. R., GLISSON, W. C., THOMPSON, W. M., VANLINGEN, J., AND BUCCAFUSCO, J. J: Cholinergic neurons and the cardiovascular response produced by central injection of substance P in the normotensive rat. Life Sci. 39: 1579-1588, 1986.
232. TRIPPODO, N. C., AND FROHLICH, E. D.: Similarities of genetic (Spontaneous) hypertension, man and rat. Circ. Res. 48: 309-319, 1981.
233. TSENG, C.-J., GER, L.-P., LIN, H.-C., AND TUNG, C.-S.: The pressor effect of nicotine in the rostral ventrolateral medulla of rats. Chin. J. Physiol. 37: 83-87, 1994.
234. VARAGIĆ, V. M.: The action of eserine on the blood pressure of the rat. Br. J. Pharmacol. 10: 349-353, 1955.
235. VARAGIĆ, V. M., AND KRSTIC, M.: Adrenergic activation by anticholinesterases. Pharmacol. Rev. 18: 799-800, 1966.
236. VARAGIĆ, V. M., MRSULJA, B., STOSIC, N., PASIC, M., AND TERZIC, M.: Glycogenolytic and hypertensive effects of physostigmine in the anti-nerve-growth-factor-serum treated rats. Eur. J. Pharmacol. 12: 194-202, 1970.
237. VARAGIĆ, V. M., PROSTRAN, M. S., STEPANOVIC, S., SAVIC, J., AND VUJNOV, S.: Transmitter interactions in the central cholinergic control of blood pressure regulation. Drug Metab. Drug Interact. 9: 49-76, 1991.
238. VARGAS, H. M., AND BREZENOFF, H. E.: Suppression of hypertension during chronic reduction of brain acetylcholine in spontaneously hypertensive rats. J. Hypertens. 6: 739-745, 1988.
239. VARGAS, H. M., AND RINGDAHL, B.: Centrally active antimuscarinic analogs of oxotremorine selectively block physostigmine-induced hypertension, but not peripheral muscarinic vasodepression. J. Pharmacol. Exp. Ther. 253: 165-170, 1990.
240. VERRIER, R. L., AND DICKERSON, L. W.: Autonomic nervous system and coronary blood flow changes related to emotional activation and sleep. Circulation 83 (suppl. 2): II-81-II-89, 1991.
241. WALKER, J. L., AND WEETMAN, D. F.: Oxotremorine-induced hypertension in the anaesthetized rat. Br. J. Pharmac. 39: 490-500, 1970.
242. WALL, S. J., YASUDA, R. P., LI, M., CIESLA, W., AND WOLFE, B. B.: Differential regulation of subtypes m1-m5 of muscarinic receptors in forebrain by chronic atropine administration. J. Pharmacol. Exp. Ther. 262: 584-588, 1992.
243. WANG, S-Z., SHENG, S-Z., JOSEPH, J. A., AND EL-FAKAHANY, E. E.: Comparison of the level of mRNA encoding ml and m2 muscarinic receptors in brains of young and aged rats. Neurosci Lett. 145: 149-152, 1992a.
244. WANG, S-Z., ZHU, S-Z., MASH, D. C., AND EL-FAKAHANY, E. E.: Comparison of the concentration of messenger RNA encoding four muscarinic receptor subtypes in control and Alzheimer brains. Molecular Br. Res. 16: 64-70, 1992b.
245. WEI, J., AND BUCCAFUSCO, J. J.: Transcriptional changes in the expression of central muscarinic receptors in the spontaneously hypertensive rat (SHR). Soc. Neurosci. Abstr. 20: 108, 1994.
246. WEI, J., MILICI, A., AND BUCCAFUSCO, J. J.: Alterations in the expression of the genes encoding specific muscarinic receptor subtypes in the hypothalamus of spontaneously hypertensive rats. Circ. Res. 76: 142-146, 1995.
247. WEI, J., WALTON, E. A., MILICI, A., AND BUCCAFUSCO, J. J.: m1-m5 Muscarinic receptor distribution in rat CNS by RT-PCR and HPLC. J. Neurochem. 63: 815-882, 1994.
248. WEINER, H.: Stressful experience and cardiorespiratory disorders. Circulation 83 (suppl. 1): II-2-II-8, 1991.
249. WERNER, U., STARKE, K., AND SCHUMANN, H. J.: Actions of clonidine and 2-(2-methyl-6-ethylcyclohexylamine)-2-oxazoline on postganglionic autonomic nerves, Arch. Int. Pharmacodyn. Ther. 195: 282-290, 1972.
250. WILLETTE, R. N., DOORLEY, B. M., AND SAPRU, H. N.: Activation of cholinergic mechanisms in the medulla oblongata reverse intravenous opioid-induced respiratory depression. J. Pharmacol. Exp. Ther. 240: 352-358, 1987.
251. WILLETTE, R. N., KRIEGER, A. J., BARCAS, P. P., AND SAPRU, H. N.: Medullary GABA receptors and the regulation of blood pressure in the rat. J. Pharmacol. Exp. Ther. 226: 893-899, 1983.
252. WILLETTE, R. N., PUNNEN, S., KRIEGER, A. J., AND SAPRU, H. N.: Cardiovascular control by cholinergic mechanisms in the rostral ventrolateral medulla. J. Pharmacol. Exp. Ther. 231: 457-463, 1984.
253. WU, Y. Y., AND WEI, E. T.: Infusions of chemicals into the brain and the development of sustained elevations of blood pressure in the rat. Life Sci. 30: 1537-1545, 1982.
254. XIAO, Y-F., AND BREZENOFF, H. E.: The role of m2 muscarinic receptors in the posterior hypothalamus in the pressor response to intracerebroventricularly-injected neostigmine. Neuropharmacology 24: 1061-1065, 1988.
255. YAKSH, T. L.; DIRKSEN, R.; HARTY, G. J.: Antinociceptive effects of intrathecally injected cholinomimetic drugs in the rat and cat. Eur. J. Pharmacol. 117: 81-88, 1985.
256. YAMADA, S., KAGAWA, Y., USHIJIMA, H., TAKAYANAGI, N., TOMITA, T., AND HAYASHI, E.: Brain nicotinic cholinoceptor binding in spontaneous hypertension. Brain Res. 410: 212-218, 1987.
257. 3H)pirenzepine. Eur. J. Pharmacol. 91: 147-149, 1983.
258. YAMORI, Y.: Neurogenic mechanisms of spontaneous hypertension. In Regulation of Blood Pressure by the Central Nervous System, ed. by G. Onesti, M. Fernandes and K. E. Kim, pp. 65-76, Grune & Stratton, New York, 1976.
259. YAMORI, Y.: Pathogenesis of spontaneous hypertension as a model for essential hypertension. Jap. Circ. J. 41: 259-266, 1977.
260. YAMORI, Y.: Development of the spontaneously hypertensive rat (SHR) and of various spontaneous rat models, and their implications. In Handbook of Hypertension: Experimental and Genetic Models of Hypertension, ed. by W. de Jong, vol. 4, pp. 224-239, Elsevier Science Publishers, New York, 1984.
261. YASUDA, R. P., CIESLA, W., FLORES, L. R., WALL, S. J., LI, M., SATKUS, S. A., WEISSTEIN, J. S., SPAGNOLA, B. V., AND WOLFE, B. B.: Development of antisera selective for m4 and m5 muscarinic cholinergic receptors: distribution of m4 and m5 receptors in rat brain. Mol. Pharmacol. 43: 149-157, 1993.
262. ZHUO, M., MELLER, S. T., AND GEBHART, G. F.: Endogenous nitric oxide is required for tonic cholinergic inhibition of spinal mechanical transmission. Pain 54: 71-78, 1993.