Synthesis and biological evaluation of cycloalkylidene carboxylic acids as novel effectors of Ras/Raf interaction

Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2002, Pages 1535-1542

  Friese, Anke ^a   Hell Momeni, Katja ^b   Zündorf, Ilse ^a   Winckler, Thomas ^a   Dingermann, Theodor ^a   Dannhardt, Gerd ^b  

^a GOETHE UNIVERSITY   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; CYCLOALKANE; CYSTEINE; MITOGEN ACTIVATED PROTEIN KINASE; PROPIONIC ACID DERIVATIVE; RAF PROTEIN; RAS PROTEIN;

ARTICLE; CARCINOGENESIS; CHEMICAL BOND; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; GENE MUTATION; MOLECULAR SIZE; NONHUMAN; PROTEIN PROTEIN INTERACTION; PROTO ONCOGENE; SIGNAL TRANSDUCTION; TWO HYBRID SYSTEM; YEAST;

AMINO ACID MOTIFS; CARBOXYLIC ACIDS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; PLASMIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-RAF; RAS PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0037187387     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm011101q     Document Type: Article

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