Species differences in GnRH activation of the LHβ promoter: Role of Egr1 and Sp1

Molecular and Cellular Endocrinology

Volumn 189, Issue 1-2, 2002, Pages 85-96

  Call, Gerald B ^a   Wolfe, Michael W ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

T3 1; Early growth response protein 1; Gonadotropin releasing hormone; L T2; Luteinizing hormone

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; GONADORELIN; LUTEINIZING HORMONE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CATTLE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; GENETIC TRANSFECTION; HORMONAL REGULATION; HORSE; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPECIES DIFFERENCE;

ANIMALS; BASE SEQUENCE; CELL LINE; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; GENES, REPORTER; GONADOTROPIN-RELEASING HORMONE; HUMANS; IMMEDIATE-EARLY PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); SEQUENCE ALIGNMENT; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; ZINC FINGERS;

EID: 0037187312     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(01)00744-4     Document Type: Article

References (28)

1. Gonadotropin-releasing hormone activates the equine luteinizing hormone beta promoter through a protein kinase C/mitogen-activated protein kinase pathway
2. A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with 'zinc finger' sequences
3. Expression of steroidogenic factor 1 in the testis requires an E box and CCAAT box in its promoter proximal region
4. Activation of luteinizing hormone beta gene by gonadotropin-releasing hormone requires the synergy of early growth response-1 and steroidogenic factor-1
5. Steroidogenic factor-1 and early growth response protein 1 act through two composite DNA binding sites to regulate luteinizing hormone beta-subunit gene expression
6. The gene encoding the β-subunit of rat luteinizing hormone. Analysis of gene structure and evolution of nucleotide sequence
7. Sp1 binds to the rat luteinizing hormone beta (LHβ) gene promoter and mediates gonadotropin-releasing hormone-stimulated expression of the LHβ subunit gene
8. Identification of cis-acting deoxyribonucleic acid elements that mediate gonadotropin-releasing hormone stimulation of the rat luteinizing hormone beta-subunit gene
9. A steroidogenic factor-1 binding site is required for activity of the luteinizing hormone beta subunit promoter in gonadotropes of transgenic mice
10. Interplay of Sp1 and Egr-1 in the proximal platelet-derived growth factor A-chain promoter in cultured vascular endothelial cells
11. Cloning of the mouse gonadotropin beta-subunit-encoding genes, II. Structure of the luteinizing hormone beta-subunit-encoding genes
12. Transcription factor ZBP-89 regulates the activity of the ornithine decarboxylase promoter
13. Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)
14. Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells
15. ZBP-89, a Kruppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter
16. A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor
17. A single gene encodes the β-subunits of equine luteinizing hormone and chorionic gonadotropin
18. Inducible PDGF A-chain transcription in smooth muscle cells is mediated by Egr-1 displacement of Sp1 and Sp3
19. Egr-1 and Sp1 interact functionally with the 5-lipoxygenase promoter and its naturally occurring mutants
20. Evolution of the genes for the β subunits of human chorionic gonadotropin and luteinizing hormone
21. Epidermal growth factor regulation of equine glycoprotein hormone alpha subunit expression in trophoblast cells
22. Multiple pituitary and ovarian defects in Krox-24 (NGFI-A, Egr-1)-targeted mice
23. Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone beta gene transcription
24. The gene for the β subunit of bovine luteinizing hormone encodes a gonadotropin mRNA with an unusually short 5′- untranslated region
25. Divergent and composite gonadotropin-releasing hormone-responsive elements in the rat luteinizing hormone subunit genes
26. The zinc finger repressor, ZBP-89, binds to the silencer element of the human vimentin gene and complexes with the transcriptional activator, Sp1
27. The equine luteinizing hormone beta-subunit promoter contains two functional steroidogenic factor-1 response elements
28. Early growth response protein 1 binds to the luteinizing hormone-beta promoter and mediates gonadotropin-releasing hormone-stimulated gene expression