In vivo monitoring of the distribution of a monoclonal antibody fragment

Vibrational Spectroscopy

Volumn 28, Issue 1, 2002, Pages 177-188

  Ramjiawan, Bram ^a   Maiti, Pradip ^b   Kaplan, Howard ^b   Fast, Darren ^b   Mantsch, Henry H ^a   Jackson, Michael ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b Vivertia Biotech Inc   (Canada)

Author keywords

Cy5.5; Imaging; Monoclonal antibody; Non invasive; Nude mouse

Indexed keywords

CAMERAS; CELLS; CHARGE COUPLED DEVICES; FLUORESCENCE; IMAGE ANALYSIS; IMAGING SYSTEMS; PHARMACOKINETICS;

MONOCLONAL ANTIBODY FRAGMENTS;

TUMORS;

EID: 0037185966     PISSN: 09242031     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-2031(01)00156-4     Document Type: Article

References (15)

1. Novel approaches to tumour detection and therapy using a combination of monoclonal antibody and cytokine
2. Monoclonal antibodies in diagnosis and therapy
3. Monoclonal antibody therapy of cancer
4. Antibodies as cytotoxic therapy
5. Clinical issues in antibody design
6. Determinants of tumour blood flow
7. Pretargeting: General principles
8. Delivery of molecular medicine to solid tumours
9. Possible consequences of human antibody responses on the biodistribution of fragments of human, humanized or chimeric monoclonal antibodies: A note of caution
10. In vivo tumour targeting of a recombinant single-chain antigen-binding protein
11. Construction, binding properties, metabolism, and tumour targeting of a single-chain Fv derived from the pancarcinoma monoclonal antibody CC49
12. Clinical evidence of efficient tumour targeting based on single-chain Fv antibody selected from a combinatorial library
13. Rapid tumour penetration of a single-chain Fv and comparison with other immunoglobulin forms
14. Noninvasive localization of tumours by immunofluorescence imaging using a single chain Fv fragment of a human monoclonal antibody with broad cancer specificity