Lack of central effects of peripherally administered adenosine A1 agonists on synaptic transmission in the rat hippocampus

Brain Research

Volumn 951, Issue 1, 2002, Pages 141-145

  Gervitz, Leon M ^a   Lutherer, Lorenz O ^a   Hamilton, Margaret E ^a   Fowler, John C ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine; Hippocampal neurons; Hypoxia; Synaptic transmission

Indexed keywords

8 CYCLOPENTYLTHEOPHYLLINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE AMINE CONGENER; CYCLOHEXYLADENOSINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN PROTECTION; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG SELECTIVITY; HIPPOCAMPUS; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTIC TRANSMISSION;

ADENOSINE; ANIMALS; CARDIOVASCULAR PHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; HYPOXIA-ISCHEMIA, BRAIN; MALE; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; SYNAPSES; SYNAPTIC TRANSMISSION; THEOPHYLLINE;

EID: 0037183731     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)03154-2     Document Type: Article

References (17)

1. Bischofberger N., Jacobson K.A., von Lubitz D.K. Adenosine A1 receptor agonists as clinically viable agents for treatment of ischemic brain disorders. Ann. NY Acad. Sci. 825:1997;23-29.
2. Brodie M.S., Lee K., Fredholm B.B., Stahle L., Dunwiddie T.V. Central versus peripheral mediation of responses to adenosine receptor agonists: evidence against a central mode of action. Brain Res. 415:1987;323-330.
3. Bryan P.T., Marshall J.M. Adenosine receptor subtypes and vasodilatation in rat skeletal muscle during systemic hypoxia: a role for A1 receptors. J. Physiol. 514:(Pt. 1):1999;151-162.
4. Coney A.M., Marshall J.M. Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia. J. Physiol. (Lond.). 509:1998;507-518.
5. Deckert J., Gleiter C.H. Adenosine - an endogenous neuroprotective metabolite and neuromodulator. J. Neural. Transm. Suppl. 43:1994;23-31.
6. Fowler J.C. Purine release and inhibition of synaptic transmission during hypoxia and hypoglycemia in rat hippocampal slices. Neurosci. Lett. 157:1993;83-86.
7. Fredholm B.B. Adenosine and neuroprotection. Int. Rev. Neurobiol. 40:1997;259-280.
8. Gervitz L.M., Lutherer L.O., Davies D.G., Pirch J.H., Fowler J.C. Adenosine induces initial hypoxic-ischemic depression of synaptic transmission in the rat hippocampus in vivo. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280:2001;R639-645.
9. Hinschen A.K., Rose'Meyer R.B., Headrick J.P. Age-related changes in A(1)-adenosine receptor-mediated bradycardia. Am. J. Physiol. Heart Circ. Physiol. 278:2000;H789-795.
10. Kempski O., Seiwert T., Otsuka H., Heimann A., Nakase H. Modelling of the ischemic penumbra. Acta Neurochir. Suppl. 73:1999;41-44.
11. Marshall J.M. The Joan Mott Prize Lecture. The integrated response to hypoxia: from circulation to cells. Exp. Physiol. 84:1999;449-470.
12. Marston H.M., Finlayson K., Maemoto T., Olverman H.J., Akahane A., Sharkey J., Butcher S.P. Pharmacological characterization of a simple behavioral response mediated selectively by central adenosine A1 receptors, using in vivo and in vitro techniques. J. Pharmacol. Exp. Ther. 285:1998;1023-1030.
13. Rudolphi K.A., Schubert P., Parkinson F.E., Fredholm B.B. Neuroprotective role of adenosine in cerebral ischaemia. Trends Pharmacol. Sci. 13:1992;439-445.
14. Schubert P., Ogata T., Marchini C., Ferroni S., Rudolphi K. Protective mechanisms of adenosine in neurons and glial cells. Ann. NY Acad. Sci. 825:1997;1-10.
15. Shryock J.C., Belardinelli L. Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology. Am. J. Cardiol. 79:1997;2-10.
16. Stella L., Berrino L., Maione S., de Novellis V., Rossi F. Cardiovascular effects of adenosine and its analogs in anaesthetized rats. Life Sci. 53:1993;755-763.
17. Von Lubitz D.K., Lin R.C., Bischofberger N., Beenhakker M., Boyd M., Lipartowska R., Jacobson K.A. Protection against ischemic damage by adenosine amine congener, a potent and selective adenosine A1 receptor agonist. Eur. J. Pharmacol. 369:1999;313-317.