Detection of radiation and cyclophosphamide-induced mutations in individual mouse sperm at a human expanded trinucleotide repeat locus transgene

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 516, Issue 1-2, 2002, Pages 121-138

  Zhang, Yun ^a,d   Monckton, Darren G ^b   Siciliano, Michael J ^a   Connor, Thomas H ^c   Meistrich, Marvin L ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^d CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

Cyclophosphamide; Germline mutation; Myotonic dystrophy microsatellite repeat; Radiation; Single genome equivalent PCR; Transgenic mice

Indexed keywords

BIOLOGICAL MARKER; CYCLOPHOSPHAMIDE; MICROSATELLITE DNA; REPETITIVE DNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DELETION MUTANT; EMBRYO DEVELOPMENT; GENE AMPLIFICATION; GENE DELETION; GENE LOCUS; GENE MUTATION; GENETIC STABILITY; MOUSE; MUTATION RATE; MYOTONIC DYSTROPHY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RADIATION DETECTION; RADIATION EXPOSURE; SPERM; SPERMATOCYTE; SPERMATOGONIUM; SPONTANEOUS MUTATION; STEM CELL; TRANSGENE; TRANSGENIC MOUSE; TRINUCLEOTIDE REPEAT;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; BLOTTING, SOUTHERN; CYCLOPHOSPHAMIDE; DNA MUTATIONAL ANALYSIS; DNA PRIMERS; HUMANS; MALE; MICE; MICE, TRANSGENIC; MUTATION; MYOTONIC DYSTROPHY; POLYMERASE CHAIN REACTION; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; SPERMATOZOA; TRINUCLEOTIDE REPEAT EXPANSION; WHOLE-BODY IRRADIATION;

MUS MUSCULUS;

EID: 0037177537     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(02)00035-9     Document Type: Article

References (50)

1. Mutagenicity of anticancer drugs in mammalian germ cells
2. The children of parents exposed to atomic bombs: Estimates of the genetic doubling dose of radiation for humans
3. Genetic disease in offspring of long-term survivors of childhood and adolescent cancer
4. Further evidence for elevated human minisatellite mutation rate in Belarus 8 years after the Chernobyl accident
5. Human minisatellites, repeat DNA instability and meiotic recombination
6. Direct analysis by small-pool PCR of MS205 minisatellite mutation rates in sperm after mutagenic therapies
7. Minisatellite mutation frequency in human sperm following radiotherapy
8. Frequency of minisatellite repeat number changes at the MS205 locus in human sperm before and after cancer chemotherapy
9. Molecular changes in the offspring of liquidators who emigrated to Israel from the Chernobyl disaster area
10. Similar origins of two mouse minisatellites within transposon-like LTRs
11. Radiation-induced germline instability at minisatellite loci
12. Somatic mosaicism, germline expansions, germline reversions and intergenerational reductions in myotonic dystrophy males: Small pool PCR analyses
13. Studying human mutations by sperm typing: Instability of CAG trinucleotide repeats in the human androgen receptor gene
14. Single sperm analysis of the trinucleotide repeats in the Huntington's disease gene: Quantification of the mutation frequency spectrum
15. Hypermutable myotonic dystrophy CTG repeats in transgenic mice
16. Age and insertion site dependence of repeat number instability of a human DM1 transgene in individual mouse sperm
17. Cytotoxic effects of chemotherapeutic drugs on mouse testis cells
18. Evidence for cyclophosphamide-induced gene conversion and mutation in mouse germ cells
19. 3H-thymidine
20. Human germline mutation analysis by single genome PCR: Application to dynamic mutations
21. Radiation damage to mouse testis cells from 99m technetium pertechnetate
22. Radiation induction of germline mutation at a hypervariable mouse minisatellite locus
23. Triplet repeats form secondary structures that escape DNA repair in yeast
24. Mouse minisatellite mutations induced by ionizing radiation
25. Induction of minisatellite mutations in the mouse germline by low-dose chronic exposure to gamma-radiation and fission neutrons
26. No correlation between germline mutation at repeat DNA and meiotic crossover in male mice exposed to X-rays or cisplatin
27. Dose-response of a radiation induction of a germline mutation at a hypervariable mouse minisatellite locus
28. Stage specificity, dose response, and doubling dose for mouse minisatellite germ-line mutation induced by acute radiation
29. Fitness loss and germline mutations in barn swallows breeding in Chernobyl
30. Synaptonemal complex damage as a measure of genotoxicity at meiosis
31. Induction of germline-length mutations at the minisatellites PC-1 and PC-2 in male mice exposed to polychlorinated biphenyls and diesel exhaust emissions
32. Multilocus DNA fingerprinting reveals high rate of heritable genetic mutation in herring gulls nesting in an industrialized urban site
33. Repeat instability at human minisatellites arising from meiotic recombination
34. The mouse Ms6hm hypervariable microsatellite forms a hairpin and two unusual tetraplexes
35. Transgenerational mutation by radiation
36. Genetic analysis of children of atomic bomb survivors
37. Very high mutation rate in offspring of Chernobyl accident liquidators
38. Monitoring spontaneous and induced human mutation by RAPD-PCR: A response to [38]
39. Biological implications of the DNA structures associated with disease-causing triplet repeats
40. Trinucleotide expansion in haploid germ cells by gap repair
41. Double-strand break repair can lead to high frequencies of deletions within short CAG/CTG trinucleotide repeats
42. Trinucleotide repeats affect DNA replication in vivo
43. Deletion errors generated during replication of CAG repeats
44. Radiation-induced genomic instability
45. Dramatic, expansion-biased, age-dependent, tissue-specific somatic mosaicism in a transgenic mouse model of triplet repeat instability
46. Cis-acting modifiers of expanded CAG/CTG triplet repeat expandability: Associations with flanking GC content and proximity to CpG islands
47. Complex gene conversion events in germline mutation at human minisatellites
48. Patterns of instability of expanded CAG repeats at the ERDA1 locus in general populations
49. A novel, heritable, expanding CTG repeat in an intron of the SEF2-1 gene on chromosome 18q21.1