A role for protein kinase C and its substrates in the action of valproic acid in the brain: Implications for neural plasticity

Brain Research

Volumn 934, Issue 1, 2002, Pages 69-80

  Watterson, Jeannette M ^a   Watson, David G ^a   Meyer, Edwin M ^b   Lenox, Robert H ^c  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

GAP 43; Immortalized hippocampal cells (HN33); MARCKS; Neurite outgrowth; Protein kinase C; Valproic acid

Indexed keywords

ISOENZYME; MARCKS PROTEIN; NEUROMODULIN; PROTEIN KINASE C; RUBOXISTAURIN; VALPROIC ACID;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME SUBSTRATE; GROWTH RATE; LONG TERM EXPOSURE; NERVE CELL DIFFERENTIATION; NERVE CELL GROWTH; NERVE CELL MEMBRANE; NERVE CELL PLASTICITY; NEURITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINASE INHIBITION; RAT; REGULATORY MECHANISM;

ANIMALS; ANTICONVULSANTS; BRAIN; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE, TRANSFORMED; CYTOSKELETON; DOWN-REGULATION; ENZYME INHIBITORS; FEMALE; GAP-43 PROTEIN; HIPPOCAMPUS; HUMANS; INDOLES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOENZYMES; MALEIMIDES; MEMBRANE PROTEINS; MICE; NERVOUS SYSTEM MALFORMATIONS; NEURITES; NEURONAL PLASTICITY; NEURONS; PREGNANCY; PROTEIN KINASE C; PROTEINS; TERATOGENS; VALPROIC ACID;

EID: 0037177449     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)02362-4     Document Type: Article

References (92)

1. The MARCKS brothers: A family of protein kinase C substrates
2. Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice
3. Depletion of 43-kD growth-associated protein in primary sensory neurons leads to diminished formation and spreading of growth cones
4. Absence of persistent spreading, branching and adhesion in GAP-43-depleted growth cones
5. Verification of the fetal valproate syndrome phenotype
6. The expression of GAP-43 in relation to neuronal growth and plasticity: When, where, how, and why
7. GAP-43: An intrinsic determinant of neuronal development and plasticity
8. Valproic acid and spina bifida
9. The MARCKS family of cellular protein kinase C substrates
10. Changes of nuclear protein kinase C activity and isotype composition in PC12 cell proliferation and differentiation
11. Efficacy of divalproex vs. lithium and placebo in the treatment of mania
12. Protein kinase C activation potently down-regulates the expression of its major substrate, 80K, in Swiss 3T3 cells
13. PKC activity and PKC-alpha mRNA content are reduced in serum-derived human neuroblastoma cells without concomitant induction of differentiation
14. Chronic sodium valproate selectively decreases protein kinase C α and ε in vitro
15. Fetal valproate syndrome
16. Possible teratogenic effect of valproic acid
17. Nerve growth factor-induced differentiation of PC12 cells employs the PMA-insensitive protein kinase C-zeta isoform
18. Teratogenicity of valproic acid
19. The fetal valproate syndrome
20. Upregulation of bcl-2 by the mood stabilizer valproic acid: The role of the ERK/RSK/CREB signaling pathway
21. Methionine reduces the valproic acid-induced spina bifida rate in mice without altering valproic acid kinetics
22. Selective activation by bryostatin-1 demonstrates unique roles for PKC epsilon in neurite extension and tau phosphorylation
23. Protein kinase C-epsilon is implicated in neurite outgrowth in differentiating human neuroblastoma cells
24. GAP-43: Putting constraints on neuronal plasticity
25. Analysis of the role of calmodulin binding and sequestration in neuromodulin (GAP-43) function
26. Cranial nerves and ganglia are altered after in vitro treatment of mouse embryos with valproic acid (VPA) and 4-en-VPA
27. Teratology for the obstetrician: Current status
28. Lack of attenuation of valproic acid-induced embryotoxicity by compounds involved in one-carbon transfer reactions
29. Lack of attenuation of valproic acid-induced effects by folinic acid in rat embryos in vitro
30. Effect of supplemental folic acid on valproic acid-induced embryotoxicity and tissue zinc levels in vivo
31. Protein kinase C activation and down-regulation in relation to phorbol ester-induced differentiation of SH-SY5Y human neuroblastoma cells
32. The potential for isozyme-selective modulation of protein kinase C
33. An inhibitory fragment derived from protein kinase C-epsilon prevents enhancement of nerve growth factor responses by ethanol and phorbol esters
34. Overexpression of ε-protein kinase C enhances nerve growth factor-induced phosphorylation of mitogen-activated protein kinases and neurite outgrowth
35. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC β inhibitor
36. Protein kinase inhibitor, staurosporine, induces a mature neuronal phenotype in SH-SY5Y human neuroblastoma cells through an alpha-, beta-, and zeta-protein kinase C-independent pathway
37. Inhibition of nerve growth factor-induced B-50/GAP-43 expression by antisense oligomers interferes with neurite outgrowth of PC12 cells
38. (S)-13-[(Dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno- 1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)- dione (LY333531) and related analogues: Isozyme selective inhibitors of protein kinase Cβ
39. Nerve growth cones isolated from fetal rat brain. III. Calcium-dependent protein phosphorylation
40. Neuronal properties and trophic activities of immortalized hippocampal cells from embryonic and young adult mice
41. Intracellular delivery of protein kinase C-α or -ε isoform-specific antibodies promotes acquisition of a morphologically differentiated phenotype in neuroblastoma cells
42. Differential expression and subcellular localization of protein kinase C α, β, γ, δ, and ε isoforms in SH-SY5Y neuroblastoma cells: Modifications during differentiation
43. Myristoylated alanine-rich C kinase substrate (MARCKS): A molecular target for the therapeutic action of mood stabilizers in the brain?
44. In-utero exposure to valproate and neural tube defects
45. Absence of cortical barrels in GAP-43 knockout mice
46. Regulation of signal transduction pathways by mood-stabilizing agents: Implications for the delayed onset of therapeutic efficacy
47. Perturbations of cellular functions integral to neural tube formation by the putative teratogen sodium valproate
48. The anticonvulsant sodium valproate specifically induces the expression of a rat glial heat shock protein which is identified as the collagen type IV receptor
49. The anticonvulsant valproate teratogen restricts the glial cell cycle at a defined point in the mid-G1 phase
50. Effect of reduced myristoylated alanine-rich C kinase substrate expression on hippocampal mossy fiber development and spatial learning in mutant mice: Transgenic rescue and interactions with gene background
51. Expression of the myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein (MRP) in the prefrontal cortex and hippocampus of suicide victims
52. Comparative distribution of myristoylated alanine-rich C kinase substrate (MARCKS) and F1/GAP-43 gene expression in the adult rat brain
53. Monoclonal antibodies show that kinase C phosphorylation of GAP-43 during axonogenesis is both spatially and temporally restricted in vivo
54. Distribution and phosphorylation of the growth associated protein GAP-43 in regenerating sympathetic neurons in culture
55. Teratogenic effects of sodium valproate in mice and rats at midgestation and at term
56. Overexpression of protein kinase C-δ and -ε in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity
57. Protein kinase C isotypes in human erythroleukemia (K562) cell proliferation and differentiation
58. Multi-institutional study on the teratogenicity and fetal toxicity of antiepileptic drugs: A report of a collaborative study group in Japan
59. Valproic acid and its metabolites: Placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers
60. Neural tube defect: Embryology, causes, genetic counseling, and antenatal diagnosis
61. Methionine decreases the embryotoxicity of sodium valproate in the rat: In vivo and in vitro observations
62. Localization of the MARCKS (87 kDa) protein, a major specific substrate for protein kinase C, in rat brain
63. The specific inhibitor of protein kinase C, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H7), induces morphological change and cell differentiation of human neural crest-derived cell lineages
64. Protein kinase C-alpha and -epsilon are enriched in growth cones of differentiating SH-SY5Y human neuroblastoma cells
65. r 87,000 protein kinase C substrate from rat brain
66. Protein kinase C isoenzymes in human neuroblasts. Involvement of PKC epsilon in cell differentiation
67. Differential changes in the phosphorylation of the protein kinase C substrates myristoylated alanine-rich C kinase substrate and growth-associated protein-43/B-50 following Schaffer collateral long-term potentiation and long-term depression
68. Therapeutic levels of sodium valproate inhibit mitotic indices in cells of neural origin
69. Can vitamin supplements prevent neural tube defects? Current evidence and ongoing investigations
70. Maternal valproic acid and congenital neural tube defects
71. r80,000 protein in intact quiescent 3T3 cells
72. Neurofilament proteins
73. The translocation and involvement of protein kinase C in mossy fiber-CA3 long-term potentiation in hippocampus of the rat brain
74. Protein kinase C
75. Neuronal pathfinding is abnormal in mice lacking the neuronal growth protein GAP-43
76. MARCKS deficiency in mice leads to abnormal brain development and perinatal death
77. Nonmyristoylated MARCKS complements some but not all of the developmental defects associated with MARCKS deficiency in mice
78. The protein kinase C family for neuronal signaling
79. Possible valproate teratogenicity
80. Expression of protein kinase C-alpha (PKC-alpha) and MYCN mRNAs in human neuroblastoma cells and modulation during morphological differentiation induced by retinoic acid
81. Valproic acid-induced neural tube defects: Reduction by folinic acid in the mouse
82. Regulation of neurite outgrowth through protein kinase C and protease nexin-1 in neuroblastoma cell
83. Cell type-specific expression of the genes for the protein kinase C family: Down regulation of mRNAs for PKC α and nPKC ε upon in vitro differentiation of a mouse neuroblastoma cell line Neuro 2a
84. Chronic lithium exposure leads to the down-regulation of both MARCKS mRNA and protein in immortalized hippocampal cells
85. Sodium valproate down-regulates the myristoylated alanine-rich C kinase substrate (MARCKS) in immortalized hippocampal cells: A property of protein kinase C-mediated mood stabilizers
86. Overexpression of protein kinase C-ζ stimulates leukemic cell differentiation
87. Translocation and activation of protein kinase C in striatal neurons in primary culture: Relationship to phorbol dibutyrate actions on the inositol phosphate generating system and neurotransmitter release
88. Estimating chemical developmental hazard in a chicken embryo limb bud micromass system
89. Fetal valproate syndrome: Is there a recognisable phenotype?
90. Differential expression of PKC isoforms and PC12 cell differentiation
91. PKC-epsilon, via its regulatory domain and independently of its catalytic domain, induces neurite-like processes in neuroblastoma cells