Effect of chronic treatment with the protein kinase C inhibitor staurosporine on the acquisition and expression of contextual fear conditioning

European Journal of Pharmacology

Volumn 441, Issue 3, 2002, Pages 151-155

  Li, Xiao Bai ^a   Inoue, Takeshi ^a   Koyama, Tsukasa ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Anxiety; Conditioned fear stress; Protein kinase C inhibitor; Staurosporine

Indexed keywords

PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; STAUROSPORINE; CARRIER PROTEIN; PROTEIN KINASE MODULATOR; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; BEHAVIOR; CONDITIONING; CONTROLLED STUDY; DRUG EFFECT; EMOTION; FEAR; LEARNING; MALE; MEMORY; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STRESS; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; METABOLISM; PAIN ASSESSMENT; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMAL; CARRIER PROTEINS; CONDITIONING (PSYCHOLOGY); DOSE-RESPONSE RELATIONSHIP, DRUG; FEAR; MALE; PAIN MEASUREMENT; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; STAUROSPORINE; SUPPORT, NON-U.S. GOV'T; ANIMALS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS;

EID: 0037177364     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)01441-3     Document Type: Article

References (33)

1. Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA
2. A role for the Ras signaling pathway in synaptic transmission and long-term memory
3. Differentiating analgesic and non-analgesic drug activities on rat hot plate: Effect of behavioral endpoint
4. Synaptic plasticity in fear conditioning circuits: Induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body
5. NMDA receptors - Their role in long-term potentiation
6. Serotonin in psychiatric pathophysiology: A review of data from experimental and clinical research
7. Conditional and unconditional components of postshock freezing
8. Contextual fear, gestalt memories, and the hippocampus
9. The neuroanatomical and neurochemical basis of conditioned fear
10. A role for amygdaloid PKA and PKC in the acquisition of long-term conditional fear memories in rats
11. Serotonin reuptake inhibitors reduce conditioned fear stress-induced freezing behavior in rats
12. Postsynaptic induction and PKA-dependent expression of LTP in the lateral amygdala
13. Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning
14. Serotonergic activation reduces defensive freezing in the conditioned fear paradigm
15. Effect of citalopram a selective serotonin reuptake inhibitor on the acquisition of conditioned freezing
16. Effect of chronic administration of flesinoxan and fluvoxamine on freezing behavior induced by conditioned fear
17. Monoamine oxidase inhibitors reduce conditioned fear stress-induced freezing behavior in rats
18. Inhibition of postsynaptic PKC or CaMKll blocks induction but not expression of LTP
19. Long-term potentiation in the amygdala: A mechanism for emotional learning and memory
20. Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo
21. Fear conditioning induces a lasting potentiation of synaptic currents in vitro
22. Staurosporine facilitates recovery from the basal forebrain-lesion-induced impairment of learning and deficit of cholinergic neuron in rats
23. Inhibitors of calmodulin and protein kinase C block different phases of hippocampal long-term potentiation
24. Long-term potentiation and N-methyl-D-aspartate receptors: Foundations of memory and neurological disease
25. LTP is accompanied by commensurate enhancement of auditory-evoked responses in a fear conditioning circuit
26. Fear conditioning induces associative long-term potentiation in the amygdala
27. Staurosporine, K-252 and UCN-01: Potent but nonspecific inhibitors of protein kinases
28. Memory consolidation for contextual and auditory fear conditioning is dependent on protein synthesis, PKA, and MAP kinase
29. 3H]PDBu (a marker for protein kinase C) in the amygdala, and re-exposure to the stressful context reactivates the increase
30. Pretreatment with caerulein protects agonist memory impairment induced by protein kinase C inhibitors in the rat
31. Historic review of research on protein kinase C in learning and memory
32. Postsynaptic protein kinase C essential to induction and maintenance of long-term potentiation in the hippocampal CA1 region
33. A role for the β isoform of protein kinase C in fear conditioning