Aneuploidy, centrosome activity and chromosome instability in cells deficient in homologous recombination repair

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 504, Issue 1-2, 2002, Pages 149-155

  Griffin, Carol S ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

Aneuploidy; Centrosomes; Chromosome aberrations; Homologous recombination repair

Indexed keywords

ANEUPLOIDY; ANIMAL CELL; ARTICLE; CELL MUTANT; CELL REGENERATION; CENTROSOME; CHROMATID; CHROMOSOME; CHROMOSOME ABERRATION; CHROMOSOME SEGREGATION; CONTROLLED STUDY; DNA REPAIR; GENETIC DISORDER; GENETIC STABILITY; GENETIC TRANSFECTION; HOMOLOGOUS RECOMBINATION; MITOSIS SPINDLE; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

ANEUPLOIDY; ANIMALS; CELL LINE; CENTROSOME; CHROMOSOME ABERRATIONS; DNA REPAIR; DNA-BINDING PROTEINS; HUMANS; RECOMBINATION, GENETIC; SISTER CHROMATID EXCHANGE; TUMOR CELLS, CULTURED;

CRICETINAE;

EID: 0037173440     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(02)00088-X     Document Type: Article

References (40)

1. Homology-directed repair is a major double-strand break repair pathway in mammalian cells
2. Homologous recombinational repair of DNA ensures mammalian chromosome stability
3. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
4. Evidence for simultaneous protein interactions between rad51 paralogs
5. Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation
6. Genetic instability in colorectal cancers
7. Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination
8. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
9. Rescue of arrested replication forks by homologous recombination
10. Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice
11. The XRCC2 human repair gene influences recombinational rearrangements leading to chromatid breaks
12. The spindle checkpoint
13. Evidence that replication fork components catalyse establishment of cohesion between sister chromatids
14. Kinetochores and the checkpoint mechanism that monitors for defects in the chromosome segregation machinery
15. "It takes two to tango": Understanding how centrosome duplication is regulated throughout the cell cycle
16. Centrosome maturation
17. Centrosome defects and genetic instability in malignant tumours
18. Centrosome hypertropy in human breast tumours: Implications for genomic stability and cell polarity
19. Centrosomes and cancer
20. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
21. Abnormal centrosome amplification in the absence of p53
22. Cell cycle independent interaction of CDC2 with the centrosome which is associated with the nuclear matrix-intermediate filament scaffold
23. GFP tagging reveals human polo-like kinase 1 at the kinetochore/centromere region of mitotic chromosomes
24. A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators
25. Centrosome defects can account for cellular and genetic changes that characterise prostate cancer progression
26. Distantly related sequences in the α and β subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and in common nucleotide binding fold
27. BRCA1 is associated with the centrosome during mitosis
28. Cell cycle dependant localisation of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes
29. Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells
30. Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification
31. TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression
32. Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair
33. Dissociation of centrosome replication from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells
34. Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression
35. Nucleophosmin/B23 is a target of cdk2/cyclin E in centrosome duplication
36. DNA-replication/DNA-damage-dependent centrosome inactivation in Drosophila embryos
37. The checkpoint control for anaphase onset does not monitor excess numbers of spindle poles or bipolar spindle symmetry
38. Altered centrosome structure is associated with abnormal mitosis in human breast tumours
39. Centriolar satellites: Molecular characterisation, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis