Lefty proteins are long-range inhibitors of Squint-mediated Nodal signaling

Current Biology

Volumn 12, Issue 24, 2002, Pages 2124-2128

  Chen, Yu ^a   Schier, Alexander F ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; LEFT RIGHT DETERMINATION FACTOR PROTEINS; LEFT-RIGHT DETERMINATION FACTOR PROTEINS; NDR1 PROTEIN, VERTEBRATE; NDR1 PROTEIN, ZEBRAFISH; NDR2 PROTEIN, ZEBRAFISH; PROTEIN NODAL; SIGNAL PEPTIDE; TRANSFORMING GROWTH FACTOR BETA; ZEBRAFISH PROTEIN;

ANIMAL; ANIMAL EMBRYO; ARTICLE; BIOLOGICAL MODEL; BLASTULA; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; METABOLISM; MUTATION; PRENATAL DEVELOPMENT; SIGNAL TRANSDUCTION; ZEBRA FISH;

ANIMALS; BLASTULA; EMBRYO, NONMAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEOSTASIS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, BIOLOGICAL; MUTATION; OLIGONUCLEOTIDES, ANTISENSE; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; ZEBRAFISH; ZEBRAFISH PROTEINS;

ANIMALIA; CYCLOPS; DANIO RERIO; VERTEBRATA;

EID: 0037164725     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)01362-3     Document Type: Article

References (27)

1. Freeman, M. (2000). Feedback control of intercellular signalling in development, Nature 408, 313-319.
2. Schier, A.F., and Shen, M.M. (2000). Nodal signalling in vertebrate development. Nature 403, 385-389.
3. Whitman, M. (2001). Nodal signaling in early vertebrate embryos: Themes and variations. Dev. Cell 1, 605-617.
4. Schier, A.F., and Talbot, W.S. (2001). Nodal signaling and the zebrafish organizer. Int. J. Dev. Biol. 45, 289-297.
5. Juan, H., and Hamada, H. (2001). Roles of nodal-lefty regulatory loops in embryonic patterning of vertebrates. Genes Cells 6, 923-930.
6. Chen, Y., and Schier, A.F. (2001). The zebrafish Nodal signal Squint functions as a morphogen. Nature 411, 607-610.
7. Bisgrove, B.W., Essner, J.J., and Yost, H.J. (1999). Regulation of midline development by antagonism of lefty and nodal signaling. Development 126, 3253-3262.
8. Meno, C., Gritsman, K., Ohishi, S., Ohfuji, Y., Heckscher, E., Mochida, K., Shimono, A., Kondoh, H., Talbot, W.S., Robertson, E.J., et al. (1999). Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. Mol. Cell 4, 287-298.
9. Cheng, A.M., Thisse, B., Thisse, C., and Wright, C.V. (2000). The lefty-related factor Xatv acts as a feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in xenopus. Development 127, 1049-1061.
10. Tanegashima, K., Yokota, C., Takahashi, S., and Asashima, M. (2000). Expression cloning of Xantivin, a Xenopus lefty/antivin-related gene, involved in the regulation of activin signaling during mesoderm induction. Mech. Dev. 99, 3-14.
11. Thisse, B., Wright, C.V., and Thisse, C. (2000). Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo. Nature 403, 425-428.
12. Meno, C., Takeuchi, J., Sakuma, R., Koshiba-Takeuchi, K., Ohishi, S., Saijoh, Y., Miyazaki, J., ten Dijke, P., Ogura, T., and Hamada, H. (2001). Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2. Dev. Cell 1, 127-138.
13. Agathon, A., Thisse, B., and Thisse, C. (2001). Morpholino knock-down of antivin1 and antivin2 upregulates nodal signaling. Genesis 30, 178-182.
14. Thisse, C., and Thisse, B. (1999). Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction. Development 126, 229-240.
15. Turing, A.M. (1952). The chemical basis of morphogenesis. Philos. Trans. R. Soc. Lond. B237, 37-72.
16. Gierer, A., and Meinhardt, H. (1972). A theory of biological pattern formation. Kybernetik 12, 30-39.
17. Meinhardt, H., and Gierer, A. (2000). Pattern formation by local self-activation and lateral inhibition. Bioessays 22, 753-760.
18. Sakuma, R., Ohnishi Yi, Y., Meno, C., Fujii, H., Juan, H., Takeuchi, J., Ogura, T., Li, E., Miyazono, K., and Hamada, H. (2002). Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion. Genes Cells 7, 401-412.
19. Schier, A.F. (2001). Axis formation and patterning in zebrafish. Curr. Opin. Genet. Dev. 11, 393-404.
20. Erter, C.E., Solnica-Krezel, L., and Wright, C.V. (1998). Zebrafish nodal-related 2 encodes an early mesendodermal inducer signaling from the extraembryonic yolk syncytial layer. Dev. Biol. 204, 361-372.
21. Rebagliati, M.R., Toyama, R., Fricke, C., Haffter, P., and Dawid, I.B. (1998). Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry. Dev. Biol. 199, 261-272.
22. Sampath, K., Rubinstein, A.L., Cheng, A.M., Liang, J.O., Fekany, K., Solnica-Krezel, L., Korzh, V., Halpern, M.E., and Wright, C.V. (1998). Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling. Nature 395, 185-189.
23. Feldman, B., Gates, M.A., Egan, E.S., Dougan, S.T, Rennebeck, G., Sirotkin, H.I., Schier, A.F., and Talbot, W.S. (1998). Zebrafish organizer development and germ-layer formation require nodal-related signals. Nature 395, 181-185.
24. Ashe, H.L., and Levine, M. (1999). Local inhibition and long-range enhancement of Dpp signal transduction by Sog. Nature 398, 427-431.
25. Decotto, E., and Ferguson, E.L. (2001). A positive role for Short gastrulation in modulating BMP signaling during dorsoventral patterning in the Drosophila embryo. Development 128, 3831-3841.
26. Gritsman, K., Talbot, W.S., and Schier, A.F. (2000). Nodal signaling patterns the organizer. Development 127, 921-932.
27. Meinhardt, H. (2001). Organizer and axes formation as a self-organizing process. Int. J. Dev. Biol. 45, 177-188.