Estimating age of humans based on telomere shortening

Forensic Science International

Volumn 126, Issue 3, 2002, Pages 197-199

  Tsuji, Akiko ^a   Ishiko, Atsushi ^a,b   Takasaki, Tomoya ^a   Ikeda, Noriaki ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b Forensic Science Laboratory   (Japan)

Author keywords

Age estimation; Human aging; Southern blotting; Telomere shortening; Terminal restriction fragment (TRF) length

Indexed keywords

ADOLESCENT; ADULT; AGE DETERMINATION; AGED; ARTICLE; BLOOD SAMPLING; BLOOD STORAGE; CHILD; CHROMOSOME SIZE; CONTROLLED STUDY; DNA DETERMINATION; ENVIRONMENTAL FACTOR; HEREDITY; HUMAN; INFANT; NEWBORN; NORMAL HUMAN; PRIORITY JOURNAL; RESTRICTION FRAGMENT; ROOM TEMPERATURE; SOUTHERN BLOTTING; STORAGE TEMPERATURE; TELOMERE; AGING; BLOOD STAIN; CHEMISTRY; FORENSIC MEDICINE; METHODOLOGY; MIDDLE AGED; PHYSIOLOGY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; BLOOD STAINS; BLOTTING, SOUTHERN; CHILD; FORENSIC MEDICINE; HUMANS; INFANT; MIDDLE AGED; TELOMERE;

EID: 0037161498     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0379-0738(02)00086-5     Document Type: Article

References (10)

1. n, present at the telomeres of human chromosomes
2. Normal human chromosomes have long G-rich telomeric overhangs at one end
3. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
4. Telomeres shorten during ageing of human fibroblasts
5. Telomere reduction in human colorectal carcinoma and with aging
6. Short telomeres on human chromosome 17p
7. Simple, rapid, quantitative, and sensitive detection of telomere repeats in cell lysate by a hybridization protection assay
8. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
9. Detection of the age-dependent 4977 bp deletion of mitochondrial DNA
10. Estimation of age at death based on quantitation of the 4977-bp deletion of human mitochondrial DNA in skeletal muscle