A MRI spatial mapping technique for microvascular permeability and tissue blood volume based on macromolecular contrast agent distribution

Magnetic Resonance in Medicine

Volumn 37, Issue 2, 1997, Pages 236-242

  Demsar, Franci ^a   Roberts, Timothy P L ^b   Schwickert, Heidi C ^b   Shames, David M ^b   Van Dijke, Cornelis F ^b   Mann, Jeffry S ^b   Saeed, Maythem ^b   Brasch, Robert C ^b  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b NONE

Author keywords

blood pool contrast agent; MRI mapping; permeability

Indexed keywords

BLOOD VESSELS; CONTRAST MEDIA; HEMODYNAMICS; MACROMOLECULES; MAGNETIC RESONANCE IMAGING; MAPPING; MECHANICAL PERMEABILITY; PATHOLOGY; PHYSIOLOGICAL MODELS; PIXELS; TISSUE; TISSUE ENGINEERING;

AUTOMATED MAPPING; AUTOMATED METHODS; CONTRAST AGENT; CONTRAST-ENHANCED MR; DYNAMIC CONTRAST ENHANCED MRI; REPERFUSION INJURY; TISSUE BLOOD VOLUME; TISSUE CHARACTERISTICS;

BLOOD;

CONTRAST MEDIUM; GADOLINIUM PENTETATE ALBUMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; BLOOD VOLUME; BREAST ADENOCARCINOMA; COMPARTMENT MODEL; CONTRAST ENHANCEMENT; DRUG DISTRIBUTION; DRUG HALF LIFE; HISTOLOGY; INFLAMMATION; INTRAVENOUS DRUG ADMINISTRATION; MACROMOLECULE; MICROVASCULATURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; REPERFUSION INJURY; TISSUE CHARACTERIZATION;

EID: 0031012760     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.1910370216     Document Type: Article

References (45)

1. R. C. Brasch, H.-J. Weinmann, G. E. Wesbey, Contrast-enhanced NMR imaging: animal studies using gadolinium-DTPA complex. AIR 142, 625-630 (1984).
2. R. Brasch. "MRI Contrast Enhancement in the Central Nervous System; A Case Study Approach." Raven Press, New York, 1993.
3. U. Schmiedl, M. E. Moseley, M. D. Ogan, W. M. Chew, R. C. Brasch, Comparison of initial biodistribution patterns of Gd-DTPA and albumin-Gd-DTPA using rapid spin echo imaging. J. Comput. Assisted Tomogr. 1, 306-313 (1987).
4. M. D. Ogan, U. Schmiedl, M. E. Moseley, W. Grodd, H. Paajanen, R. C. Brasch, Albumin labeled with Gd-DTPA: an intravascular contrast enhancing agent for magnetic resonance blood pool imaging: preparation and characterization. Invest. Radiol. 22, :665-671 (1987).
5. U. Schmiedl, M. Ogan, H. Paajanen, M. Marotti, L. E. Croooks, A. C. Brito, R. C. Brasch, Albumin labeled with Gd-DTPA as an intravascular, blood pool-enhancing agent for MR imaging: biodistribution and imaging studies. Radiology 162, 205-210 (1987).
6. R. Brasch, Rationale and applications for macromolecular Gd-based contrast agents, in "Workshop on Contrast-Enhanced Magnetic Resonance" (R. Brasch, Ed.), pp. 163-160, Society for Magnetic Resonance in Medicine, Napa, CA, 1991.
7. E. C. Unger, P. MacDougall, P. Cullis, C. Tilcock, Liposomal Gd-DTPA: effect of encapsulation on enhancement of hepatoma model by MRI. Magn. Reson. Imaging 7, 417-423 (1989).
8. D. D. Stark, R. Weissleder, G. Elizondo, P. F. Hahn, S. Saini, L. E. Todd, J. Wittenberg, J. T. Ferrucci, Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver. Radiology 168, 297-301 (1988).
9. J. Ferrucci, D. Stark, Iron oxide-enhanced MR imaging of the liver and spleen: review of the first 5 years. AJR 155, 943-950 (1990).
10. R. B. Lauffer, A. C. Vincent, S. Padmanabhan, A. Villringer, S. Saini, D.R. Elmaleh, T. J. Bradley, Hepatobiliary MR contrast agents: 5-substituted iron-EHPG derivatives. Magn. Reson. Med, 4, 582-590 (1987).
11. A. Muehler, J. Platzek, B. Raduechel, T. Frenzel, H. J. Weinman, Characterization of a gadolinium-labeled cholesterol derivative as an organ-specific contrast agent for adrenal MR imaging. J. Magn. Reson. 5, 7-10 (1995).
12. R. Weissleder, G. Elizondo, L. Josephson, C. C. Compton, C. J. Fretz, D. D. Stark, J. T. Ferrucci, Experimental lymph node metastases: enhanced detection with MR lymphography. Radiology 171, 835-839 (1989).
13. R. Weissleder, P. Reimer, A. S. Lee, J. Wittenberg, T. J. Brady, MR receptor imaging: ultrasmall iron oxide particles targeted to asialoglycoprotien receptors. AJR 155, 1161-1167 (1990).
14. M.-Y, Su, J.-C, Jao, O. Nalcioglu, Measurement of vascular volume fraction and blood tissue permeability constants with a pharmacokinetik model: studies of rat muscle tumors with dynamic Gd-DTPA enhancement MRI. Magn. Reson. Med. 32, 714-724 (1994).
15. H. Paajanen, R. C. Brasch, U. Schmiedl, M. Ogan. Magnetic resonance imaging of local soft tissue inflammation using Gd-DTPA. Acta Radiol. 28, 79-83 (1987).
16. U. Schmiedl, M. E. Moseley, R. Sievers, M. D. Ogan, W. M. Chew, H. Engeseth, W. E. Finkbeiner, M. J. Lipton, R. C. Brasch, Magnetic resonance imaging of myocardial infarction in rats using albumin-(Gd-DTPA), a macromolecular blood-volume contrast agent in a rat model. Invest. Radiol. 22, 713-721 (1987).
17. M. G. Wikstrom, M. E. Moseley, D. L. White, J. W. Dupon, J. L. Winkelhake, J. Koppli, R. C. Brasch, Contrast enhanced MRI of tumors: comparison of Gd-DTPA and a macromolecular agent. Invest. Radiol. 24, 609-615 (1989).
18. C. L. Wolfe, M. E. Moseley, M. G. Wikstrom, R. E. Sievers, M. F. Wendland, J. W. Dupon, W. E. Finkbeiner, M. J. Lipton, W. W. Parmley, R. C. Brasch, Assessment of myocardial salvage after ischemia and reperfusion using magnetic resonance imaging and spectroscopy. Circulation 80, 969-982 (1989).
19. K. P. Aicher, J. W. Dupon, D. L. White, S. L. Aukerman, M. E. Moseley, R. Juster, W. Rosenau, J. L. Winkelhake, R. C.Brasch, Contrast-enhanced magnetic resonance imaging of tumor-bearing mice treated with human recombinant tumor necrosis factor α. Cancer Res. 50, 7376-7381 (1990).
20. M. Saeed, M. F. Wendland, T. Masui, A. J. Connolly, N. Derugin, R. C. Brasch, C. B. Higgins, Myocardial infarction: assessment with an intravascular MR contrast medium. Work-in-progress. Radiology 180, 153-160 (1991).
21. D. Shames, R. Kuwatsuru, V. Vexler, A. Muehler, R. Brasch, Measurement of capillary permeability to macromolecules by dynamic magnetic resonance imaging: a quantitative non-invasive technique. Magn. Reson. Med. 29, 616-622 (1993).
22. F. Cohen, R. Kuwatsuru, D. Shames, M. Neuder, J. S. Mann, V. Vexler, W. Rosenau, R C. Brasch, Contrast-enhanced magnetic resonance imaging estimation of altered capillary permeability in experimental mammary carcinomas after x-irradiation. Invest. Radiol. 29, 970-977 (1994).
23. R. Kuwatsuru, D. Shames, A. Mühler, J. Mintorovitch, V. Vexler, J. S. Mann, F. Cohn, D. Price, J. Huberty, R. C. Brasch, Quantification of tissue plasma volume in the rat by contrast-enhanced magnetic resonance imaging. Mag. Reson. Med. 30, 76-81 (1993).
24. R. Hilf, J. J. Freeman, I. Michel, A. Borman, Characterization of a transplantable lactating mammary tumor: endocrinological, morphological, and biochemical aspects. Cancer Res. 24, 812-823 (1963).
25. D. White, Wang S-C, K. Aicher, J. Dupon, B. Engelstad, Brasch R. Albumin-(DTPA-Gd)15-20: whole body clearance, and organ distribution of gadolinium, in "Proc. SMRI, 8th Annual Meeting, Amsterdam, 1989," p. 807.
26. U. Schmiedl, M. D. Ogan, M. E. Moseley, R. C. Brasch, Comparison of the contrast-enhancing properties of albumin-(Gd-DTPA) and Gd-DTPA at 2.0 T: an experimental study in rats. AJR 147, 1263-1270 (1986).
27. H. B. Larsson, M. Stubgaard, J. L. Frederiksen, M. Jensen, O. Henriksen, O. B. Paulson, Quantitation of blood-brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumors, Magn. Reson. Med. 16, 117-131 (1990).
28. C. Patlak, R. Blasberg, J. Fenstermacher, Graphical evaluation of blood-to-brain transfer constants from multiple time uptake data. J. Cerebr. Blood Flow Metab. 3, 1-7 (1983).
29. P. S. Cotran, V. Kumar, Robbins SL. Inflammation and repair, in "Pathologic Basis of Disease" (S. L. Robbins, V. Kumar, Eds.), Vol. 2, 4th ed, Saunders, Philadelphia, 1989.
30. G. B. Ryan, G. Majno, Acute inflammation. Am. J. Pathol. 86, 85-216 (1977).
31. R. C. Brasch, H. J. Weinmann, G. E. Wesbey, Contrast-enhanced NMR imaging: animal studies using gadolinium-DTPA complex. AJR 142, 625-630 (1984).
32. S. Raimo, I. R. Young, G. M. Bydder, 1. Rotating frame and magnetization transfer; 2. Phase imaging, in "Magnetic Resonance Imaging" (D. D. Stark, W. G. Bradley, Eds), Vol. 1, 2nd ed., Mosby, St. Louis, 1986.
33. D. G. Taylor, M. C. Bushell, Spatial mapping of translational diffusion coefficients by NMRI technique. Phys. Med. Biol. 30, 345 (1985).
34. R. J. Dickinson, A. S. Hall, A. J. Hind, Measurement of changes in tissue temperature using MR imaging. J. Comput. Assisted Tomogr. 10, 468. (1986).
35. C. L. Dumoulin, H. R.Hart, Magnetic resonance angiography. Radiology 161, 717. (1986).
36. C. J. Lewa, Z. Majewski, Temperature relationships of proton spinlatice relaxation time T1 in biological tissues. Bull. Cancer 67, 525 (1980).
37. M. Vahlensieck, F. Dombrowski, C. Leutner, U. Wagner,. Magnetization transfer contrast (MTC) and MTC-subtraction-enhancement of cartilage lesions and intracartilaginous degeneration in vitro. Skeletal Radiol. 23, 535-539 (1994).
38. W. T. Dixon, Simple proton spectroscopic imaging. Radiology 153, 189 (1984).
39. R. M. Weisskoff, S. Kiihne, MRI susceptometry-image-based measurement of absolute susceptibility of MR contrast agents and human blood. Magn. Reson. Med. 24, 375-383 (1992).
40. I. Sersa, O. Jarh, D. Franci, Magnetic resonance microscopy of electric currents. J. Magn. Reson. A111, 93-99 (1994).
41. S. L. Hanna, W. E. Reddick, D. M. Parham, S. A. Gronemeyer, Automated pixel-by-pixel mapping of dynamic contrast enhanced MR images for evaluation of osteosarcoma response to chemotherapy - preliminary results. J. Magn. Reson. 3, 849-853 (1993).
42. P. Gowland, P. Mansfield, P. Bullock, M. Stehling, B. Worthington, J. Firth, Dynamic studies of gadolinium uptake in brain tumors using inversion recovery echo planar imaging. Magn. Reson. Med. 26, 241-258 (1992).
43. A. Haase, Snapshot FLASH MRI. applications to T1, T2 and chemical shift imaging. Magn. Reson. Med. 13, 77-89 (1990).
44. H. C. Schwickert, T. P. L. Roberts, D. M. Shames, C. F. Van Dijke, A. Disston, A. Möhler, J. S. Mann, R. C. Brasch, Quantification of liver blood volume: comparison of ULSTIR-EPI, a new inversion-recovery echo-planar approach with 3D-SPGR, a fast gradient-echo sequence. Magn. Reson. Med. 34, 845-852 (1995).
45. P. S. Tofts, Kermode AG. Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts. Magn. Reson. Med. 17, 357-367 (1991).