Cyclodextrin conjugate-based controlled release system: Repeated- and prolonged-releases of ketoprofen after oral administration in rats

Journal of Controlled Release

Volumn 82, Issue 2-3, 2002, Pages 407-416

  Kamada, Makoto ^a   Hirayama, Fumitoshi ^a   Udo, Koichi ^a   Yano, Hideki ^a   Arima, Hidetoshi ^a   Uekama, Kaneto ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Anti inflammatory effect; Colon specific delivery; Cyclodextrin conjugate; Delayed release; Ketoprofen; Repeated release; Sustained release

Indexed keywords

ALPHA CYCLODEXTRIN; ANTIINFLAMMATORY AGENT; CARRAGEENAN; ETHYL CELLULOSE; KETOPROFEN; KETOPROFEN 2 HYDROXYPROPYL BETA CYCLODEXTRIN; UNCLASSIFIED DRUG; 6(A) O (2 (3 BENZOYLPHENYL)PROPIONYL) ALPHA CYCLODEXTRIN; 6(A)-O-(2-(3-BENZOYLPHENYL)PROPIONYL)-ALPHA-CYCLODEXTRIN; ALPHA CYCLODEXTRIN DERIVATIVE; BENZOPHENONE DERIVATIVE; CYCLODEXTRIN; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BODY FLUID; CECUM; COLON; CONTROLLED STUDY; DELAYED RELEASE FORMULATION; DRUG BLOOD LEVEL; DRUG CONJUGATION; EDEMA; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE PREPARATION; ANIMAL; BIOAVAILABILITY; CHEMISTRY; DRUG ERUPTION; ORAL DRUG ADMINISTRATION; TIME; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZOPHENONES; BIOLOGICAL AVAILABILITY; CARRAGEENAN; CYCLODEXTRINS; DELAYED-ACTION PREPARATIONS; DRUG ERUPTIONS; KETOPROFEN; MALE; RATS; RATS, WISTAR; TIME FACTORS; ALPHA-CYCLODEXTRINS; ANIMALS;

EID: 0037151330     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(02)00171-2     Document Type: Article

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