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Volumn 44, Issue 9, 2001, Pages 1471-1474

Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7:2′, 3′-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy

(10) McLamore, S a,d Ullrich, T a Rothman, R B b Xu, H b Dersch, C b Coop, A b,e Davis, P c Porreca, F c Jacobson, A E a Rice, K C a

a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES (United States)

b NIDA Addiction Research Center (United States)

c UNIVERSITY OF ARIZONA (United States)

d CENTER FOR DRUG EVALUATION AND RESEARCH (United States)

e UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY (United States)

Author keywords

[No Author keywords available]

Indexed keywords

17 (2 BUTENYL) 6,7 DEHYDRO 4,5ALPHA EPOXY 3,14 DIHYDROXY 6,7:2',3' INDOLOMORPHINAN; 17 (2 METHYL 2 PROPENYL) 6,7 DEHYDRO 4,5ALPHA EPOXY 3,14 DIHYDROXY 6,7:2',3' INDOLOMORPHINAN; 17 ETHYL 6,7 DEHYDRO 4,5ALPHA EPOXY 3,14 DIHYDROXY 6,7:2',3' INDOLOMORPHINAN; 6,7 DEHYDRO 4,5ALPHA EPOXY 3,14 DIHYDROXY 6,7:2',3' INDOLOMORPHINAN; DELTA OPIATE RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; NALTRINDOLE; NOROXYMORPHINDOLE DERIVATIVE; OPIATE ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOASSAY; COCAINE DEPENDENCE; CONTROLLED STUDY; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; GUINEA PIG; ILEUM MUCOSA; MORPHINE TOLERANCE; MOUSE; NONHUMAN; RECEPTOR AFFINITY; VAS DEFERENS;

ANIMALS; BINDING, COMPETITIVE; ELECTRIC STIMULATION; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUINEA PIGS; ILEUM; MALE; MICE; MORPHINANS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; RADIOLIGAND ASSAY; RECEPTORS, OPIOID; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP; VAS DEFERENS;

EID: 0035953313 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm000511w Document Type: Article

Times cited : (26)

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