Scale-up and optimization of an acoustic filter for 200 L/day perfusion of a CHO cell culture

Biotechnology and Bioengineering

Volumn 80, Issue 4, 2002, Pages 438-444

  Gorenflo, Volker M ^a   Smith, Laura ^b   Dedinsky, Bob ^b   Persson, Bo ^b   Piret, James M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b ZYMOGENETICS INC   (United States)

Author keywords

Acoustic; Cell retention; Chinese hamster ovary cells (CHO cells); Continuous; Mammalian cell culture; Optimization; Perfusion; Scale up; Separation; Separator

Indexed keywords

BIOREACTORS; CELLS; FLUID DYNAMICS; OPTIMIZATION; PROTEINS;

ACOUSTIC FILTER;

CELL CULTURE;

RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CHO CELL; FILTER; FLUID FLOW; HYDRODYNAMICS; NONHUMAN; PERFUSION; SEPARATION TECHNIQUE; TEMPERATURE DEPENDENCE;

ACOUSTICS; ANIMALS; BIOREACTORS; CELL COUNT; CELL SEPARATION; CELL SURVIVAL; CHO CELLS; CRICETINAE; EQUIPMENT DESIGN; PARTICLE SIZE; PERFUSION; PILOT PROJECTS; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TEMPERATURE;

CRICETINAE; CRICETULUS GRISEUS; MAMMALIA;

EID: 0037145631     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10386     Document Type: Article

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