Antagonist-induced μ-opioid receptor up-regulation decreases G-protein receptor kinase-2 and dynamin-2 abundance in mouse spinal cord

European Journal of Pharmacology

Volumn 446, Issue 1-3, 2002, Pages 37-42

  Patel, Minesh ^a   Gomes, Benedict ^a   Patel, Chintan ^a   Yoburn, Byron C ^a  

^a ST JOHN'S UNIVERSITY   (United States)

Author keywords

Constitutive internalization; Dynamin 2; G protein receptor kinase 2; Naltrexone; Receptor up regulation; Opioid receptor

Indexed keywords

DYNAMIN; DYNAMIN II; G PROTEIN COUPLED RECEPTOR; G PROTEIN RECEPTOR KINASE 2; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR ANTAGONIST; NALTREXONE; PLACEBO; UNCLASSIFIED DRUG; ADRBK2 PROTEIN, MOUSE; BETA ADRENERGIC RECEPTOR KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANOSINE TRIPHOSPHATASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; IMMUNOBLOTTING; INTERNALIZATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY; RECEPTOR UPREGULATION; SPINAL CORD; ANIMAL; DRUG ANTAGONISM; IN VITRO STUDY; METABOLISM; RADIOASSAY; UPREGULATION;

ANIMALS; BETA-ADRENERGIC RECEPTOR KINASE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DYNAMIN II; GTP PHOSPHOHYDROLASES; MALE; MICE; NALTREXONE; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, MU; SPINAL CORD; UP-REGULATION;

EID: 0037141754     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)01823-X     Document Type: Article

References (29)

1. Up-regulation of delta opioid receptors in neuroblastoma hybrid cells: Evidence for differences in the mechanisms of action of sodium butyrate and naltrexone
2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
3. CNS levels of mu-opioid receptor (MOR-1) mRNA during chronic treatment with morphine or naltrexone
4. Effect of adrenal and sex hormones on opioid analgesia and opioid receptor regulation
5. Chronic morphine and naltrexone fail to modify mu-opioid receptor mRNA levels in the rat brain
6. The effect of the irreversible mu-opioid receptor antagonist clocinnamox on morphine potency, receptor binding and receptor mRNA
7. Opioid receptor upregulation in mu-opioid receptor deficient CXBK and outbred Swiss Webster mice
8. Up-regulation of surface μ-opioid receptors by antagonists
9. Assessment of delta opioid antinociception and receptor mRNA levels in mouse after chronic naltrexone treatment
10. C-terminal splice variants of the mouse mu-opioid receptor differ in morphine-induced internalization and receptor resensitization
11. Inverse agonist up-regulates the constitutively active D3.49 (164) Q mutant of the rat mu-opioid receptor by stabilizing the structure and blocking constitutive internalization and down-regulation
12. Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features
13. Differential up-regulation of microsomal and synaptic membrane mu opioid receptors
14. Increased analgesic potency of mu agonists after continuous naloxone infusion in rats
15. A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated
16. The effect of mu-opioid receptor antisense on morphine potency and antagonist-induced supersensitivity and receptor upregulation
17. Antagonist-induced opiate receptor upregulation in cultures of fetal mouse spinal cord-ganglion explants
18. Chronic opioid antagonist administration upregulates mu opioid receptor binding without altering mu opioid receptor mRNA levels
19. Quantitative immunolocalization of mu opioid receptors: Regulation by naltrexone
20. Morphine-activated opioid receptors elude desensitization by beta-arrestin
21. Opioid antagonist-induced upregulation and functional supersensitivity
22. Increased analgesic potency of morphine and increased brain opioid binding sites in the rat following chronic naltrexone treatment
23. Pharmacodynamic supersensitivity and opioid receptor upregulation in the mouse
24. Chronic opioid antagonist treatment increases mu and delta receptor mediated spinal opioid analgesia
25. Chronic opioid antagonist treatment: Assessment of receptor upregulation
26. Supersensitivity to opioid analgesics following chronic opioid antagonist treatment: Relationship to receptor selectivity
27. Role for G-protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness
28. Naltrexone-induced opiate receptor supersensitivity
29. Opiate receptor upregulation and functional supersensitivity